The hippocampus is necessary for the consolidation of a task that does not require the hippocampus for initial learning

• Published in: Hippocampus Vol. 29; no. 11; pp. 1091 - 1100
• Main Authors: Schapiro, Anna C., Reid, Allison G., Morgan, Alexandra, Manoach, Dara S., Verfaellie, Mieke, Stickgold, Robert
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2019; Wiley Subscription Services, Inc
• Subjects: amnesics; Hippocampus; Learning; memory; motor sequence learning; offline consolidation; Sleep; offline consolidation; sleep; amnesics; memory; motor sequence learning
• ISSN: 1050-9631; 1098-1063
• DOI: 10.1002/hipo.23101

During sleep, the hippocampus plays an active role in consolidating memories that depend on it for initial encoding. There are hints in the literature that the hippocampus may have a broader influence, contributing to the consolidation of memories that may not initially require the area. We tested this possibility by evaluating learning and consolidation of the motor sequence task (MST) in hippocampal amnesics and demographically matched control participants. While the groups showed similar initial learning, only controls exhibited evidence of overnight consolidation. These results demonstrate that the hippocampus can be required for normal consolidation of a task without being required for its acquisition, suggesting that the area plays a broader role in coordinating memory consolidation than has previously been assumed.