Synergistic Cancer Therapeutic Effects of Locally Delivered Drug and Heat Using Multifunctional Nanoparticles

Doxorubicin‐loaded PEG‐PLGA‐Au half‐shell nanoparticles provide multifunctions, such as photothermal treatment, photothermally controlled drug delilvery, and in vivo optical imaging. In addition, the combined doxorubicin and photothermal treatments using these multifunctional nanoparticles show syne...

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Bibliographic Details
Published inAdvanced materials (Weinheim) Vol. 22; no. 36; pp. 4049 - 4053
Main Authors Lee, Sun-Mi, Park, Huiyul, Yoo, Kyung-Hwa
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 22.09.2010
WILEY‐VCH Verlag
Subjects
Animals
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Cell Line, Tumor
chemo-photothermal therapy
Contrast Media - chemistry
Doxorubicin - chemistry
Doxorubicin - pharmacology
Doxorubicin - therapeutic use
Drug Carriers - chemistry
Female
Gold - chemistry
Hot Temperature - therapeutic use
Humans
in vivo imaging
Lactic Acid - chemistry
local delivery of drug/heat
Mice
Molecular Imaging
multifunctional nanoparticle
Nanoparticles - chemistry
NIR resorance
Polyethylene Glycols - chemistry
Polyglycolic Acid - chemistry
Tumor Burden - drug effects
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Summary:Doxorubicin‐loaded PEG‐PLGA‐Au half‐shell nanoparticles provide multifunctions, such as photothermal treatment, photothermally controlled drug delilvery, and in vivo optical imaging. In addition, the combined doxorubicin and photothermal treatments using these multifunctional nanoparticles show synergistic therapeutic effects.
Bibliography:ark:/67375/WNG-CF44WZWT-9
ArticleID:ADMA201001040
istex:37A56D358EB62BAA03EEDD96EE78A6AE7C64DA05
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201001040