Subtle deficits of attention after surgery: quantifying indicators of sub syndrome delirium

• Published in: International journal of geriatric psychiatry Vol. 25; no. 10; pp. 945 - 952
• Main Authors: Lowery, David Peter, Wesnes, Keith, Brewster, Nigel, Ballard, Clive
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.10.2010; Psychology Press; Wiley Subscription Services, Inc
• Subjects: acute confusion; Aged; Aged, 80 and over; Attention - physiology; attention deficits; Biological and medical sciences; Cognition & reasoning; Cognition Disorders - complications; Cognition Disorders - diagnosis; Cohort Studies; Delirium; Delirium - diagnosis; Delirium - etiology; Delirium - psychology; dementia; Elective Surgical Procedures - adverse effects; Female; Fundamental and applied biological sciences. Psychology; General aspects; Geriatric Assessment; Geriatric psychiatry; Geriatric psychology; Geriatrics; Humans; Information processing; Male; Medical sciences; Neuropsychological Tests; Neuropsychology; Older people; Postoperative Complications - diagnosis; Postoperative Complications - etiology; Postoperative Complications - psychology; Postoperative period; Preoperative Period; Prospective Studies; Psychoanalysis; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Reaction Time - physiology; sub syndrome delirium; surgery; Human; Delirium; Postoperative; Acute; acute confusion; attention deficits; Indicator; Syndrome; Organic mental disorder; Gerontology; Treatment; Attentional disorder; sub syndrome delirium; Surgery; Degenerative disease; Elderly; Psychiatry; Mental confusion; Quantitative analysis; Dementia; Geriatrics
• ISSN: 0885-6230; 1099-1166; 1099-1166
• DOI: 10.1002/gps.2430

Objective To determine whether attentional impairments are reliable neuropsychological markers of sub syndrome delirium. Method A prospective cohort study with repeated assessment beginning pre‐operatively and continuing through the first post‐operative week. Computerized assessments of attention and the Mini‐Mental State Examination were administered with one hundred patients admitted for elective orthopedic surgery, 70 years and over and free of dementia. Acute change of cognitive status was used to identify cases of sub syndrome delirium. Results There were significant differences of post‐surgical performance between the ‘no delirium’ and ‘sub‐syndrome delirium’ groups of reaction time, global cognition, accuracy and greater variability of reaction time (p < 0.041). There were significant within subject main effects on reaction time (p = 0.001), variability of reaction time (p = 0.022) and MMSE (p = 0.000) across the cohort; but no significant interaction effect of ‘diagnosis’ * ‘time’ on the computerized measures of attention (p > 0.195). Conclusion The distinction between people with sub syndrome delirium and no delirium is difficult to quantify but computerized measures of attention might provide a sensitive indicator. Sub syndrome delirium is an observable marker of a clinical abnormality that should be exploited to improve care management for vulnerable patients. Copyright © 2010 John Wiley & Sons, Ltd.