Impact of 5-aminolevulinic acid fluorescence-guided surgery on the extent of resection of meningiomas – With special regard to high-grade tumors

Highlights • 5-ALA improved the extent of resection in meningiomas. • This improved degree of resection was not measurable by Simpson's grading. • A new grading that rates residual fluorescence is necessary. • There was a strong correlation between fluorescence intensity and WHO grade.

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Bibliographic Details
Published inPhotodiagnosis and photodynamic therapy Vol. 11; no. 4; pp. 481 - 490
Main Authors Cornelius, J.F, Slotty, P.J., MD, Kamp, M.A., MD, Schneiderhan, T.M., MD, Steiger, H.J., MD, El-Khatib, M., MD
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.12.2014
Subjects
5-ALA
Adult
Aged
Aged, 80 and over
Aminolevulinic Acid
Contrast Media
Female
Fluorescence guided surgery
Fluorescent Dyes
Hematology, Oncology and Palliative Medicine
High grade
Humans
Internal Medicine
Male
Meningeal Neoplasms - pathology
Meningeal Neoplasms - surgery
Meningioma
Meningioma - pathology
Meningioma - surgery
Microscopy, Fluorescence - methods
Middle Aged
Neoplasm Grading
Reproducibility of Results
Sensitivity and Specificity
Skull base
Surgery, Computer-Assisted - methods
Fluorescence guided surgery
Skull base
Aminolevulinic acid
5-ALA
Meningioma
High grade
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Summary:Highlights • 5-ALA improved the extent of resection in meningiomas. • This improved degree of resection was not measurable by Simpson's grading. • A new grading that rates residual fluorescence is necessary. • There was a strong correlation between fluorescence intensity and WHO grade.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2014.07.008