The neuroprotective effect of vitamin E on waterpipe tobacco smoking-induced memory impairment: The antioxidative role

• Published in: Life sciences (1973) Vol. 222; pp. 46 - 52
• Main Authors: Alzoubi, Karem H., Halboup, Abdulsalam M., Alomari, Mahmoud A., Khabour, Omar F.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.04.2019; Elsevier BV
• Subjects: Biomarkers; Catalase; Cognitive ability; Data acquisition; Health risks; Hippocampus; Impairment; Learning; Long term memory; Maze learning; Memory; Neuroprotection; Oxidative stress; Smoking; Spatial discrimination learning; Spatial memory; Tobacco; Tobacco smoking; Tocopherol; Vitamin E; Water pipes; Waterpipe; Learning; Oxidative stress; Vitamin E; Memory; Waterpipe; Tobacco smoking
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2019.02.050

Tobacco smoking is associated with a vast range of adverse health effects, including diminished cognitive and anti-oxidative capabilities. Conversely, vitamin E (VitE) is known to enhance data acquisition and retention and hippocampal oxidative defense. No studies, however, examined the protective effect of VitE with tobacco administration. Therefore, this study examined the protective effect of VitE on the cognitive and oxidative debilitating effects induced by waterpipe smoking. Wistar male rats were divided into four groups: waterpipe smoking, VitE, waterpipe combined with VitE, and control group. The exposure to waterpipe and VitE was for one month and then spatial learning and memory were assesses using Radial Arms Water Maze. Additionally, oxidative stress biomarkers (Catalase, GPx, and TBARS, GSH, GSSG, and GSH/GSSG ratio) were assessed in the hippocampus. The results revealed that waterpipe smoking impaired short-term and long-term memory (P < 0.05). Waterpipe smoking reduced activity of catalase (P < 0.05), GPx (P < 0.05) and GSH/GSSG ratio (P < 0.05) in the hippocampus. Administration of VitE prevented memory impairment and alterations in oxidative stress biomarkers. waterpipe smoking induces short-term and long-term memory impairments, which were prevented by administration of VitE via its anti-oxidative properties.