Halothane-induced alteration in the fluidity of rat brain synaptosomal membranes and its relationship to anesthesia

Concentrations of halothane 1.43% or higher abolished the pain response and induced anesthesia. Halothane increased membrane fluidity of synaptosomes and microsomes both at non-anesthetic and anesthetic concentrations. Changes in fluidity in synaptosomes did not return to control levels even after t...

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Bibliographic Details
Published inAnnals of the New York Academy of Sciences Vol. 625; p. 433
Main Authors Sastry, B V, Franks, J J, Surber, M J
Format Journal Article
LanguageEnglish
Published United States 01.01.1991
Subjects
Anesthesia
Animals
Brain - drug effects
Brain - physiology
Halothane - pharmacology
Intracellular Membranes - drug effects
Intracellular Membranes - physiology
Male
Membrane Fluidity - drug effects
Microsomes - drug effects
Microsomes - physiology
Pain - physiopathology
Rats
Rats, Inbred Strains
Reference Values
Synaptosomes - drug effects
Synaptosomes - physiology
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Summary:Concentrations of halothane 1.43% or higher abolished the pain response and induced anesthesia. Halothane increased membrane fluidity of synaptosomes and microsomes both at non-anesthetic and anesthetic concentrations. Changes in fluidity in synaptosomes did not return to control levels even after the animals recovered from anesthesia. Alteration in membrane fluidity by halothane is a non-selective effect and may not play a definitive role in anesthesia.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1991.tb33872.x