In Vitro Antibacterial and Anti-Inflammatory Properties of Imidazolium Poly(ionic liquids) Microspheres Loaded in GelMA-PEG Hydrogels

Repairing damaged tissue caused by bacterial infection poses a significant challenge. Traditional antibacterial hydrogels typically incorporate various components such as metal antimicrobials, inorganic antimicrobials, organic antimicrobials, and more. However, drawbacks such as the emergence of mul...

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Bibliographic Details
Published inGels Vol. 10; no. 4; p. 278
Main Authors Zhou, Chao, Sun, Mengdi, Wang, Danni, Yang, Mingmei, Loh, Jia Ling Celestine, Xu, Yawen, Zhang, Ruzhi
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.04.2024
Subjects
anti-inflammation
Anti-inflammatory drugs
antibacterial
Antibacterial agents
Antimicrobial agents
Bacterial infections
Biocompatibility
Chemical properties
Cytotoxicity
Differentiation (biology)
Dopamine
Drug resistance
Drug therapy
E coli
Emulsion polymerization
Endothelial cells
Gelatin
hydrogel
Hydrogels
Imidazole
Ionic liquids
Microspheres
Molecular weight
Particle size
Pharmaceutical research
poly(ionic liquids)
Polyethylene glycol
Polymers
tissue repairing
Toxicity
China
tissue repairing
anti-inflammation
antibacterial
hydrogel
poly(ionic liquids)
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Summary:Repairing damaged tissue caused by bacterial infection poses a significant challenge. Traditional antibacterial hydrogels typically incorporate various components such as metal antimicrobials, inorganic antimicrobials, organic antimicrobials, and more. However, drawbacks such as the emergence of multi-drug resistance to antibiotics, the low antibacterial efficacy of natural agents, and the potential cytotoxicity associated with metal antibacterial nanoparticles in hydrogels hindered their broader clinical application. In this study, we successfully developed imidazolium poly(ionic liquids) (PILs) polymer microspheres (APMs) through emulsion polymerization. These APMs exhibited notable antibacterial effectiveness and demonstrated minimal cell toxicity. Subsequently, we integrated the APMs into a gelatin methacryloyl (GelMA)-polyethylene glycol (PEG) hydrogel. This composite hydrogel not only showcased strong antibacterial and anti-inflammatory properties but also facilitated the migration of human skin fibroblasts (HSF) and human umbilical vein endothelial cells (HUVECs) and promoted osteogenic differentiation in vitro.
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ISSN:2310-2861
2310-2861
DOI:10.3390/gels10040278