Metabolic Syndrome, Insulin Resistance, and Cognitive Dysfunction: Does Your Metabolic Profile Affect Your Brain?

Dementia and type 2 diabetes are both characterized by long prodromal phases, challenging the study of potential risk factors and their temporal relation. The progressive relation among metabolic syndrome, insulin resistance (IR), and dementia has recently been questioned, wherefore the aim of this...

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Published inDiabetes (New York, N.Y.) Vol. 66; no. 7; pp. 1957 - 1963
Main Authors Neergaard, Jesper S., Dragsbæk, Katrine, Christiansen, Claus, Nielsen, Henning B., Brix, Susanne, Karsdal, Morten A., Henriksen, Kim
Format Journal Article
LanguageEnglish
Published United States American Diabetes Association 01.07.2017
Subjects
Aged
Blood Glucose - metabolism
Cognition & reasoning
Cognitive ability
Cognitive Dysfunction - epidemiology
Cohort Studies
Dementia
Dementia disorders
Denmark - epidemiology
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - metabolism
Fasting
Female
Geriatrics
Homeostasis
Humans
Insulin
Insulin Resistance
Logistic Models
Metabolic syndrome
Metabolic Syndrome - epidemiology
Metabolic Syndrome - metabolism
Middle Aged
Multivariate Analysis
Older people
Prospective Studies
Risk factors
Denmark
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Summary:Dementia and type 2 diabetes are both characterized by long prodromal phases, challenging the study of potential risk factors and their temporal relation. The progressive relation among metabolic syndrome, insulin resistance (IR), and dementia has recently been questioned, wherefore the aim of this study was to assess the potential association among these precursors of type 2 diabetes and cognitive dysfunction. Using data from the Prospective Epidemiological Risk Factor (PERF) Study (n = 2,103), a prospective study of elderly women in Denmark, we found that impaired fasting plasma glucose concentration was associated with 44% (9–91%) larger probability of cognitive dysfunction. In addition, subjects above the HOMA-IR threshold (HOMA-IR >2.6) had 47% (9–99%) larger odds of cognitive dysfunction. The associations could indicate that a significant proportion of dementia cases in women is likely to be preventable by effective prevention and control of the insulin homeostasis.
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ISSN:0012-1797
1939-327X
1939-327X
DOI:10.2337/db16-1444