Indocyanine green conjugated phototheranostic nanoparticle for photodiagnosis and photodynamic therapy

• Published in: Photodiagnosis and photodynamic therapy Vol. 39; p. 103041
• Main Authors: Shinoda, Kenta, Suganami, Akiko, Moriya, Yasumitsu, Yamashita, Masamichi, Tanaka, Tsutomu, Suzuki, Akane S., Suito, Hiroshi, Akutsu, Yasunori, Saito, Kengo, Shinozaki, Yoko, Isojima, Kazuoki, Nakamura, Naohito, Miyauchi, Yasushi, Shirasawa, Hiroshi, Matsubara, Hisahiro, Okamoto, Yoshiharu, Nakayama, Toshinori, Tamura, Yutaka
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.09.2022
• Subjects: Indocyanine green; Light-emitting diode; Near-infrared; Photodynamic reaction; Phototheranostics; DOPE; PBS; PDT; SUPR; EPR; Indocyanine green; LED; ICG; iDOPE; Phototheranostics; PTT; PEG; NIR-PIT; NIR; Near-infrared; Photodynamic reaction; LP-iDOPE; Light-emitting diode; DOPC
• ISSN: 1572-1000; 1873-1597
• DOI: 10.1016/j.pdpdt.2022.103041

•Evaluated the phototheranostic properties of LP-iDOPE for cancer imaging-mediated photodynamic reaction.•LP-iDOPE specificcally accumulated in tumors with the EPR effect.•NIR-LED light irradiation at the LP-iDOPE accumulated tumors activated the immune response induced by photodynamic and photothermal effects. : Phototheranostics represents a highly promising paradigm for cancer therapy, although selecting an appropriate optical imager and sensitizer for clinical use remains challenging. : Liposomally formulated phospholipid-conjugated indocyanine green, denoted as LP-iDOPE, was developed as phototheranostic nanoparticle and its cancer imaging-mediated photodynamic reaction, defined as the immune response induced by photodynamic and photothermal effects, was evaluated with a near-infrared (NIR)-light emitting diode (LED) light irradiator. : Using in vivo NIR fluorescence imaging, we demonstrated that LP-iDOPE was selectively delivered to tumor sites with high accumulation and a long half-life. Following low-intensity NIR-LED light irradiation on the tumor region of LP-iDOPE accumulated, effector CD8+ T cells were activated at the secondary lymphoid organs, migrated, and subsequently released cytokines including interferon-γ and tumor necrosis factor-α, resulting in effective tumor regression. : Our anti-cancer strategy based on tumor-specific LP-iDOPE accumulation and low-intensity NIR-LED light irradiation to the tumor regions, i.e., photodynamic reaction, represents a promising approach to noninvasive cancer therapy.