Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18)

• Published in: Immunology letters Vol. 168; no. 1; pp. 13 - 21
• Main Authors: Svoboda, Eliška, Schneider, Andrea E, Sándor, Noémi, Lermann, Ulrich, Staib, Peter, Kremlitzka, Mariann, Bajtay, Zsuzsa, Barz, Dagmar, Erdei, Anna, Józsi, Mihály
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2015
• Subjects: Allergy and Immunology; Aspartic Acid Endopeptidases - immunology; Aspartic Acid Endopeptidases - metabolism; Blotting, Western; Candida albicans; Candida albicans - enzymology; Candida albicans - immunology; Candida albicans - physiology; CD11b Antigen - genetics; CD11b Antigen - immunology; CD11b Antigen - metabolism; CD11c Antigen - genetics; CD11c Antigen - immunology; CD11c Antigen - metabolism; CD18 Antigens - genetics; CD18 Antigens - immunology; CD18 Antigens - metabolism; Cell Line, Tumor; Cells, Cultured; Complement; Complement Factor H - immunology; Complement Factor H - metabolism; CR3; Cytokines - immunology; Cytokines - metabolism; Enzyme-Linked Immunosorbent Assay; Factor H; Fungal pathogen; Fungal Proteins - immunology; Fungal Proteins - metabolism; Host-Pathogen Interactions - immunology; Humans; Immune evasion; Integrin alphaXbeta2 - genetics; Integrin alphaXbeta2 - immunology; Integrin alphaXbeta2 - metabolism; Macrophage-1 Antigen - genetics; Macrophage-1 Antigen - immunology; Macrophage-1 Antigen - metabolism; Protease; RNA Interference; Sap2; Candida albicans; Fungal pathogen; FH; CR4; CR3; complement receptor type 4 (CD11c/CD18); Complement; Immune evasion; factor H; CCP; secreted aspartic protease 2; Protease; MDM; Sap2; complement control protein domain; complement receptor type 3 (CD11b/CD18); monocyte-derived macrophages; Factor H
• ISSN: 0165-2478; 1879-0542
• DOI: 10.1016/j.imlet.2015.08.009

Highlights • Complement factor H binds to human macrophages via CD11b/CD18 and CD11c/CD18. • Factor H enhances Candida albicans and zymosan induced release of IL-1β and IL-6. • Sap2 of Candida albicans inactivates factor H, CD11b/CD18 and CD11c/CD18.