The BioGRID interaction database: 2017 update

The Biological General Repository for Interaction Datasets (BioGRID: https://thebiogrid.org) is an open access database dedicated to the annotation and archival of protein, genetic and chemical interactions for all major model organism species and humans. As of September 2016 (build 3.4.140), the Bi...

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Published inNucleic acids research Vol. 45; no. D1; pp. D369 - D379
Main Authors Chatr-Aryamontri, Andrew, Oughtred, Rose, Boucher, Lorrie, Rust, Jennifer, Chang, Christie, Kolas, Nadine K, O'Donnell, Lara, Oster, Sara, Theesfeld, Chandra, Sellam, Adnane, Stark, Chris, Breitkreutz, Bobby-Joe, Dolinski, Kara, Tyers, Mike
Format Journal Article
LanguageEnglish
Published England Oxford University Press 04.01.2017
Subjects
Animals
Computational Biology - methods
Data Curation
Data Mining
Database Issue
Databases, Genetic
Humans
Protein Interaction Mapping
Protein Interaction Maps
Protein Processing, Post-Translational
Proteins - chemistry
Proteins - genetics
Proteins - metabolism
Software
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Summary:The Biological General Repository for Interaction Datasets (BioGRID: https://thebiogrid.org) is an open access database dedicated to the annotation and archival of protein, genetic and chemical interactions for all major model organism species and humans. As of September 2016 (build 3.4.140), the BioGRID contains 1 072 173 genetic and protein interactions, and 38 559 post-translational modifications, as manually annotated from 48 114 publications. This dataset represents interaction records for 66 model organisms and represents a 30% increase compared to the previous 2015 BioGRID update. BioGRID curates the biomedical literature for major model organism species, including humans, with a recent emphasis on central biological processes and specific human diseases. To facilitate network-based approaches to drug discovery, BioGRID now incorporates 27 501 chemical-protein interactions for human drug targets, as drawn from the DrugBank database. A new dynamic interaction network viewer allows the easy navigation and filtering of all genetic and protein interaction data, as well as for bioactive compounds and their established targets. BioGRID data are directly downloadable without restriction in a variety of standardized formats and are freely distributed through partner model organism databases and meta-databases.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkw1102