Heme A1M'ed at the kidney in sickle cell disease

In this issue of Blood , Ofori-Acquah et al investigate hemolysis, hemopexin deficiency, and kidney function in sickle cell disease (SCD) and report that (1) acute elevations in heme lead to kidney damage in hemopexin-deficient states, and (2) a compensatory rise in α-1 microglobulin (A1M) relative...

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Bibliographic Details
Published inBlood Vol. 135; no. 13; pp. 979 - 981
Main Author Saraf, Santosh L.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 26.03.2020
American Society of Hematology
SeriesRed Cells, Iron, and Erythropoiesis
Subjects
Acute Kidney Injury
Anemia, Sickle Cell
Heme
Hemopexin
Humans
Kidney
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Summary:In this issue of Blood , Ofori-Acquah et al investigate hemolysis, hemopexin deficiency, and kidney function in sickle cell disease (SCD) and report that (1) acute elevations in heme lead to kidney damage in hemopexin-deficient states, and (2) a compensatory rise in α-1 microglobulin (A1M) relative to hemopexin concentration is associated with acute kidney injury. 1
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ISSN:0006-4971
1528-0020
1528-0020
DOI:10.1182/blood.2020005134