LncRNA MIR155HG functions as a ceRNA of miR-223-3p to promote cell pyroptosis in human degenerative NP cells
Nucleus pulposus (NP) cell pyroptosis plays a critical role in the pathogenesis of intervertebral disk degeneration (IDD). MIR155 host gene (MIR155HG) is a long non-coding RNA with pro-inflammatory activity. However, very little is known about its role in NP cell pyroptosis. This study aimed to obse...
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| Published in | Clinical and experimental immunology Vol. 207; no. 2; pp. 241 - 252 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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England
Oxford University Press
04.04.2022
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| Abstract | Nucleus pulposus (NP) cell pyroptosis plays a critical role in the pathogenesis of intervertebral disk degeneration (IDD). MIR155 host gene (MIR155HG) is a long non-coding RNA with pro-inflammatory activity. However, very little is known about its role in NP cell pyroptosis. This study aimed to observe the impact of MIR155HG on cell pyroptosis and to explore the underlying mechanism in human degenerative NP cells. Our results demonstrated that MIR155HG expression was significantly increased in human degenerative NP tissue samples and showed a positive correlation with Pfirrmann score. Overexpression of MIR155HG through a lentiviral vector decreased miR-223-3p levels, up-regulated NLRP3 expression and induced cell pyroptosis in human degenerative NP cells. A ceRNA action mode was identified among MIR155HG, miR-223-3p, and NLRP3. The stimulatory effect of MIR155HG on human degenerative NP cell pyroptosis was significantly reversed by pretreatment with miR-223-3p mimic or NLRP3 siRNA. In summary, these data suggest that MIR155HG sponges miR-223-3p to promote NLRP3 expression, leading to induction of cell pyroptosis in human degenerative NP cells. Targeting MIR155HG could be a novel and promising strategy to slow down the progression of IDD. |
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| AbstractList | Nucleus pulposus (NP) cell pyroptosis plays a critical role in the pathogenesis of intervertebral disk degeneration (IDD). MIR155 host gene (MIR155HG) is a long non-coding RNA with pro-inflammatory activity. However, very little is known about its role in NP cell pyroptosis. This study aimed to observe the impact of MIR155HG on cell pyroptosis and to explore the underlying mechanism in human degenerative NP cells. Our results demonstrated that MIR155HG expression was significantly increased in human degenerative NP tissue samples and showed a positive correlation with Pfirrmann score. Overexpression of MIR155HG through a lentiviral vector decreased miR-223-3p levels, up-regulated NLRP3 expression and induced cell pyroptosis in human degenerative NP cells. A ceRNA action mode was identified among MIR155HG, miR-223-3p, and NLRP3. The stimulatory effect of MIR155HG on human degenerative NP cell pyroptosis was significantly reversed by pretreatment with miR-223-3p mimic or NLRP3 siRNA. In summary, these data suggest that MIR155HG sponges miR-223-3p to promote NLRP3 expression, leading to induction of cell pyroptosis in human degenerative NP cells. Targeting MIR155HG could be a novel and promising strategy to slow down the progression of IDD.
Graphical Abstract
MIR155HG is highly expressed in human degenerative NP tissue. MIR155HG promotes human degenerative NP cell pyroptosis through the miR-223-3p/NLRP3 pathway. MIR155HG may be a potential therapeutic target for IDD. Nucleus pulposus (NP) cell pyroptosis plays a critical role in the pathogenesis of intervertebral disk degeneration (IDD). MIR155 host gene (MIR155HG) is a long non-coding RNA with pro-inflammatory activity. However, very little is known about its role in NP cell pyroptosis. This study aimed to observe the impact of MIR155HG on cell pyroptosis and to explore the underlying mechanism in human degenerative NP cells. Our results demonstrated that MIR155HG expression was significantly increased in human degenerative NP tissue samples and showed a positive correlation with Pfirrmann score. Overexpression of MIR155HG through a lentiviral vector decreased miR-223-3p levels, up-regulated NLRP3 expression and induced cell pyroptosis in human degenerative NP cells. A ceRNA action mode was identified among MIR155HG, miR-223-3p, and NLRP3. The stimulatory effect of MIR155HG on human degenerative NP cell pyroptosis was significantly reversed by pretreatment with miR-223-3p mimic or NLRP3 siRNA. In summary, these data suggest that MIR155HG sponges miR-223-3p to promote NLRP3 expression, leading to induction of cell pyroptosis in human degenerative NP cells. Targeting MIR155HG could be a novel and promising strategy to slow down the progression of IDD. Abstract Nucleus pulposus (NP) cell pyroptosis plays a critical role in the pathogenesis of intervertebral disk degeneration (IDD). MIR155 host gene (MIR155HG) is a long non-coding RNA with pro-inflammatory activity. However, very little is known about its role in NP cell pyroptosis. This study aimed to observe the impact of MIR155HG on cell pyroptosis and to explore the underlying mechanism in human degenerative NP cells. Our results demonstrated that MIR155HG expression was significantly increased in human degenerative NP tissue samples and showed a positive correlation with Pfirrmann score. Overexpression of MIR155HG through a lentiviral vector decreased miR-223-3p levels, up-regulated NLRP3 expression and induced cell pyroptosis in human degenerative NP cells. A ceRNA action mode was identified among MIR155HG, miR-223-3p, and NLRP3. The stimulatory effect of MIR155HG on human degenerative NP cell pyroptosis was significantly reversed by pretreatment with miR-223-3p mimic or NLRP3 siRNA. In summary, these data suggest that MIR155HG sponges miR-223-3p to promote NLRP3 expression, leading to induction of cell pyroptosis in human degenerative NP cells. Targeting MIR155HG could be a novel and promising strategy to slow down the progression of IDD. |
| Author | Zhou, You-Bin Huang, Xu-Dong Zhang, Jian Zou, Yong-Cheng Yang, Wei Zhang, Tao |
| AuthorAffiliation | The First Affiliated Hospital, Orthopedic Center, Hengyang Medical School, University of South China , Hengyang, Hunan , China |
| AuthorAffiliation_xml | – name: The First Affiliated Hospital, Orthopedic Center, Hengyang Medical School, University of South China , Hengyang, Hunan , China |
| Author_xml | – sequence: 1 givenname: Wei orcidid: 0000-0001-7993-8170 surname: Yang fullname: Yang, Wei organization: The First Affiliated Hospital, Orthopedic Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China – sequence: 2 givenname: Xu-Dong surname: Huang fullname: Huang, Xu-Dong organization: The First Affiliated Hospital, Orthopedic Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China – sequence: 3 givenname: Tao surname: Zhang fullname: Zhang, Tao organization: The First Affiliated Hospital, Orthopedic Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China – sequence: 4 givenname: You-Bin surname: Zhou fullname: Zhou, You-Bin organization: The First Affiliated Hospital, Orthopedic Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China – sequence: 5 givenname: Yong-Cheng surname: Zou fullname: Zou, Yong-Cheng organization: The First Affiliated Hospital, Orthopedic Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China – sequence: 6 givenname: Jian surname: Zhang fullname: Zhang, Jian organization: The First Affiliated Hospital, Orthopedic Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35020847$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1080/10520295.2019.1622782 10.1016/j.cca.2015.09.011 10.1371/journal.pone.0048485 10.1517/14728222.2013.834330 10.1038/s41418-018-0212-6 10.1302/2046-3758.59.BJR-2016-0032.R1 10.3892/ijmm.2016.2573 10.4049/jimmunol.1100477 10.1042/BSR20192567 10.1111/jcmm.16061 10.3390/ijms21062165 10.1016/j.cell.2011.07.014 10.1155/2017/5601593 10.1016/j.cca.2015.08.029 10.1016/S0140-6736(15)60692-4 10.1136/jmedgenet-2015-103334 10.1038/s41413-020-00125-x 10.1016/j.biopha.2019.109015 10.1002/iub.1747 10.1016/j.bbrc.2021.04.090 10.1016/j.gene.2012.12.009 10.1007/s10753-019-00986-3 10.1016/j.intimp.2021.107866 10.1016/j.cell.2013.06.020 10.1186/s13075-019-1967-y 10.7150/jca.48989 10.3892/etm.2020.9563 10.1089/dna.2021.0038 10.1155/2021/4657014 10.1186/s12891-020-3086-y 10.1161/ATVBAHA.120.315525 10.1111/1756-185X.14089 10.1016/j.biopha.2018.01.154 10.1155/2021/5584447 10.1111/cei.13587 10.1186/s12967-017-1194-8 10.1016/j.tibs.2016.10.004 10.4149/gpb_2021013 10.1016/j.ymthe.2019.09.013 10.1186/s13075-018-1743-4 10.1111/jcmm.15784 10.1038/nature12986 10.1007/s10495-013-0839-1 10.1007/s00018-017-2626-6 10.18632/aging.103109 10.1038/s41419-020-03263-6 10.1111/cpr.12941 10.1186/s13046-019-1132-0 10.18632/aging.103314 10.1016/j.bbrc.2020.03.161 10.1016/j.neucir.2020.01.001 10.1038/nrg.2016.20 |
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| Keywords | MIR155HG IDD ceRNA pyroptosis NLRP3 miR-223-3p |
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| References | Jiang (2022040512190131600_CIT0029) 2021; 41 Feng (2022040512190131600_CIT0054) 2006; 88 Yang (2022040512190131600_CIT0027) 2019; 12 Ulitsky (2022040512190131600_CIT0053) 2013; 154 Zhang (2022040512190131600_CIT0002) 2016; 37 Bai (2022040512190131600_CIT0028) 2020; 12 He (2022040512190131600_CIT0043) 2020; 526 Global Burden of Disease Study 2013 Collaborators. (2022040512190131600_CIT0001) 2015; 386 Cunha (2022040512190131600_CIT0036) 2018; 20 Ye (2022040512190131600_CIT0046) 2016; 5 Cui (2022040512190131600_CIT0008) 2020; 21 Shi (2022040512190131600_CIT0039) 2017; 42 Wang (2022040512190131600_CIT0013) 2015; 450 Tay (2022040512190131600_CIT0023) 2014; 505 Dong (2022040512190131600_CIT0051) 2019; 42 Hasvik (2022040512190131600_CIT0016) 2019; 21 Wu (2022040512190131600_CIT0050) 2019; 38 Lyu (2022040512190131600_CIT0003) 2021; 9 Rodríguez (2022040512190131600_CIT0017) 2012; 7 Li (2022040512190131600_CIT0010) 2019; 117 Stich (2022040512190131600_CIT0037) 2020; 21 Wang (2022040512190131600_CIT0004) 2021; 12 Wang (2022040512190131600_CIT0019) 2018; 70 Tang (2022040512190131600_CIT0044) 2021; 2021 Tang (2022040512190131600_CIT0052) 2021; 101 Song (2022040512190131600_CIT0011) 2020; 40 Wang (2022040512190131600_CIT0032) 2021; 24 Di Martino (2022040512190131600_CIT0055) 2013; 17 Tian (2022040512190131600_CIT0022) 2021; 204 Zhou (2022040512190131600_CIT0006) 2021; 559 Yamamura (2022040512190131600_CIT0033) 2018; 75 Moen (2022040512190131600_CIT0018) 2017; 15 Ding (2022040512190131600_CIT0038) 2013; 18 Zhang (2022040512190131600_CIT0025) 2019; 94 Zhao (2022040512190131600_CIT0047) 2021; 54 Tang (2022040512190131600_CIT0009) 2020; 12 Feng (2022040512190131600_CIT0056) 2017; 2017 Frank (2022040512190131600_CIT0040) 2019; 26 Wang (2022040512190131600_CIT0014) 2018; 99 Fan (2022040512190131600_CIT0026) 2021; 40 Liao (2022040512190131600_CIT0005) 2021; 2021 Zhang (2022040512190131600_CIT0042) 2020; 24 Wang (2022040512190131600_CIT0015) Jimenez Calvente (2022040512190131600_CIT0031) 2020; 28 Yang (2022040512190131600_CIT0045) 2015; 450 Yu (2022040512190131600_CIT0030) 2020; 11 Zhang (2022040512190131600_CIT0007) 2021; 21 Thomson (2022040512190131600_CIT0049) 2016; 17 Long (2022040512190131600_CIT0020) 2020; 24 Salmena (2022040512190131600_CIT0048) 2011; 146 Bergsbaken (2022040512190131600_CIT0041) 2011; 187 Elton (2022040512190131600_CIT0034) 2013; 532 Ren (2022040512190131600_CIT0021) 2020; 12 Zhang (2022040512190131600_CIT0012) 2021; 40 Cosamalón-Gan (2022040512190131600_CIT0035) 2021; 32 Qi (2022040512190131600_CIT0024) 2015; 52 |
| References_xml | – volume: 94 start-page: 606 year: 2019 ident: 2022040512190131600_CIT0025 article-title: Systematic identification of lncRNAs and circRNAs-associated ceRNA networks in human lumbar disc degeneration. publication-title: Biotech Histochem doi: 10.1080/10520295.2019.1622782 contributor: fullname: Zhang – volume: 450 start-page: 333 year: 2015 ident: 2022040512190131600_CIT0013 article-title: MicroRNAs: new players in intervertebral disc degeneration. publication-title: Clin Chim Acta doi: 10.1016/j.cca.2015.09.011 contributor: fullname: Wang – volume: 7 start-page: e48485 year: 2012 ident: 2022040512190131600_CIT0017 article-title: Molecular characterization of chronic lymphocytic leukemia patients with a high number of losses in 13q14. publication-title: PLoS One doi: 10.1371/journal.pone.0048485 contributor: fullname: Rodríguez – volume: 17 start-page: 1461 year: 2013 ident: 2022040512190131600_CIT0055 article-title: Autoimmunity in intervertebral disc herniation: from bench to bedside. publication-title: Expert Opin Ther Targets doi: 10.1517/14728222.2013.834330 contributor: fullname: Di Martino – volume: 26 start-page: 99 year: 2019 ident: 2022040512190131600_CIT0040 article-title: Pyroptosis versus necroptosis: similarities, differences, and crosstalk. publication-title: Cell Death Differ doi: 10.1038/s41418-018-0212-6 contributor: fullname: Frank – volume: 5 start-page: 412 year: 2016 ident: 2022040512190131600_CIT0046 article-title: Bone morphogenetic protein-2 provokes interleukin-18-induced human intervertebral disc degeneration. publication-title: Bone Joint Res doi: 10.1302/2046-3758.59.BJR-2016-0032.R1 contributor: fullname: Ye – volume: 37 start-page: 1439 year: 2016 ident: 2022040512190131600_CIT0002 article-title: Molecular mechanisms of cell death in intervertebral disc degeneration (Review). publication-title: Int J Mol Med doi: 10.3892/ijmm.2016.2573 contributor: fullname: Zhang – volume: 187 start-page: 2748 year: 2011 ident: 2022040512190131600_CIT0041 article-title: Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation. publication-title: J Immunol doi: 10.4049/jimmunol.1100477 contributor: fullname: Bergsbaken – volume: 40 start-page: BSR20192567 year: 2020 ident: 2022040512190131600_CIT0011 article-title: LncRNA MIR155HG contributes to smoke-related chronic obstructive pulmonary disease by targeting miR-128-5p/BRD4 axis. publication-title: Biosci Rep doi: 10.1042/BSR20192567 contributor: fullname: Song – volume: 24 start-page: 14405 year: 2020 ident: 2022040512190131600_CIT0020 article-title: MiR-223-3p inhibits rTp17-induced inflammasome activation and pyroptosis by targeting NLRP3. publication-title: J Cell Mol Med doi: 10.1111/jcmm.16061 contributor: fullname: Long – volume: 21 start-page: 2165 year: 2020 ident: 2022040512190131600_CIT0037 article-title: Degeneration of lumbar intervertebral discs: characterization of Anulus Fibrosus tissue and cells of different degeneration grades. publication-title: Int J Mol Sci doi: 10.3390/ijms21062165 contributor: fullname: Stich – volume: 146 start-page: 353 year: 2011 ident: 2022040512190131600_CIT0048 article-title: A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? publication-title: Cell doi: 10.1016/j.cell.2011.07.014 contributor: fullname: Salmena – volume: 2017 start-page: 5601593 year: 2017 ident: 2022040512190131600_CIT0056 article-title: ROS: crucial intermediators in the pathogenesis of intervertebral disc degeneration. publication-title: Oxid Med Cell Longev doi: 10.1155/2017/5601593 contributor: fullname: Feng – ident: 2022040512190131600_CIT0015 article-title: Upregulated miR-154 promotes ECM degradation in intervertebral disc degeneration. publication-title: J Cell Biochem contributor: fullname: Wang – volume: 450 start-page: 262 year: 2015 ident: 2022040512190131600_CIT0045 article-title: Interleukin-1β in intervertebral disk degeneration. publication-title: Clin Chim Acta doi: 10.1016/j.cca.2015.08.029 contributor: fullname: Yang – volume: 386 start-page: 743 issue: 9995 year: 2015 ident: 2022040512190131600_CIT0001 article-title: Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. publication-title: Lancet doi: 10.1016/S0140-6736(15)60692-4 contributor: fullname: Global Burden of Disease Study 2013 Collaborators. – volume: 52 start-page: 710 year: 2015 ident: 2022040512190131600_CIT0024 article-title: ceRNA in cancer: possible functions and clinical implications. publication-title: J Med Genet doi: 10.1136/jmedgenet-2015-103334 contributor: fullname: Qi – volume: 9 start-page: 7 year: 2021 ident: 2022040512190131600_CIT0003 article-title: Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions. publication-title: Bone Res doi: 10.1038/s41413-020-00125-x contributor: fullname: Lyu – volume: 117 start-page: 109015 year: 2019 ident: 2022040512190131600_CIT0010 article-title: LncRNA MIR155HG regulates M1/M2 macrophage polarization in chronic obstructive pulmonary disease. publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2019.109015 contributor: fullname: Li – volume: 70 start-page: 479 year: 2018 ident: 2022040512190131600_CIT0019 article-title: MicroRNA-223 inhibits lipopolysaccharide-induced inflammatory response by directly targeting Irak1 in the nucleus pulposus cells of intervertebral disc. publication-title: IUBMB Life doi: 10.1002/iub.1747 contributor: fullname: Wang – volume: 559 start-page: 106 year: 2021 ident: 2022040512190131600_CIT0006 article-title: Morin attenuates pyroptosis of nucleus pulposus cells and ameliorates intervertebral disc degeneration via inhibition of the TXNIP/NLRP3/Caspase-1/IL-1β signaling pathway. publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2021.04.090 contributor: fullname: Zhou – volume: 532 start-page: 1 year: 2013 ident: 2022040512190131600_CIT0034 article-title: Regulation of the MIR155 host gene in physiological and pathological processes. publication-title: Gene doi: 10.1016/j.gene.2012.12.009 contributor: fullname: Elton – volume: 42 start-page: 1265 year: 2019 ident: 2022040512190131600_CIT0051 article-title: Sinomenine attenuates cartilage degeneration by regulating miR-223-3p/NLRP3 inflammasome signaling. publication-title: Inflammation doi: 10.1007/s10753-019-00986-3 contributor: fullname: Dong – volume: 101 start-page: 107866 year: 2021 ident: 2022040512190131600_CIT0052 article-title: Notoginsenoside R1 suppresses inflammatory response and the pyroptosis of nucleus pulposus cells via inactivating NF-κB/NLRP3 pathways. publication-title: Int Immunopharmacol doi: 10.1016/j.intimp.2021.107866 contributor: fullname: Tang – volume: 12 start-page: 3632 year: 2019 ident: 2022040512190131600_CIT0027 article-title: LincRNA-SLC20A1 (SLC20A1) promotes extracellular matrix degradation in nucleus pulposus cells in human intervertebral disc degeneration by targeting the miR-31-5p/MMP3 axis. publication-title: Int J Clin Exp Pathol contributor: fullname: Yang – volume: 154 start-page: 26 year: 2013 ident: 2022040512190131600_CIT0053 article-title: lincRNAs: genomics, evolution, and mechanisms. publication-title: Cell doi: 10.1016/j.cell.2013.06.020 contributor: fullname: Ulitsky – volume: 21 start-page: 186 year: 2019 ident: 2022040512190131600_CIT0016 article-title: Up-regulation of circulating microRNA-17 is associated with lumbar radicular pain following disc herniation. publication-title: Arthritis Res Ther doi: 10.1186/s13075-019-1967-y contributor: fullname: Hasvik – volume: 12 start-page: 5241 year: 2021 ident: 2022040512190131600_CIT0004 article-title: Gasdermin E-mediated programmed cell death: an unpaved path to tumor suppression. publication-title: J Cancer doi: 10.7150/jca.48989 contributor: fullname: Wang – volume: 21 start-page: 131 year: 2021 ident: 2022040512190131600_CIT0007 article-title: Role of lncRNA PART1 in intervertebral disc degeneration and associated underlying mechanism. publication-title: Exp Ther Med doi: 10.3892/etm.2020.9563 contributor: fullname: Zhang – volume: 40 start-page: 811 year: 2021 ident: 2022040512190131600_CIT0012 article-title: lncRNA MIR155HG accelerates the progression of sepsis via upregulating MEF2A by sponging miR-194-5p. publication-title: DNA Cell Biol doi: 10.1089/dna.2021.0038 contributor: fullname: Zhang – volume: 2021 start-page: 4657014 year: 2021 ident: 2022040512190131600_CIT0044 article-title: Propionibacterium acnes accelerates intervertebral disc degeneration by inducing pyroptosis of nucleus pulposus cells via the ROS-NLRP3 pathway. publication-title: Oxid Med Cell Longev doi: 10.1155/2021/4657014 contributor: fullname: Tang – volume: 21 start-page: 149 year: 2020 ident: 2022040512190131600_CIT0008 article-title: LncRNA MAGI2-AS3 is down-regulated in intervertebral disc degeneration and participates in the regulation of FasL expression in nucleus pulposus cells. publication-title: BMC Musculoskelet Disord doi: 10.1186/s12891-020-3086-y contributor: fullname: Cui – volume: 41 start-page: 1675 year: 2021 ident: 2022040512190131600_CIT0029 article-title: Circular RNA Calm4 regulates hypoxia-induced pulmonary arterial smooth muscle cells pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 axis. publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.120.315525 contributor: fullname: Jiang – volume: 88 start-page: 25 year: 2006 ident: 2022040512190131600_CIT0054 article-title: Extracellular matrix in disc degeneration. publication-title: J Bone Joint Surg Am contributor: fullname: Feng – volume: 24 start-page: 599 year: 2021 ident: 2022040512190131600_CIT0032 article-title: MiR-223-3p and miR-22-3p inhibit monosodium urate-induced gouty inflammation by targeting NLRP3. publication-title: Int J Rheum Dis doi: 10.1111/1756-185X.14089 contributor: fullname: Wang – volume: 99 start-page: 725 year: 2018 ident: 2022040512190131600_CIT0014 article-title: MiR-21 promotes ECM degradation through inhibiting autophagy via the PTEN/akt/mTOR signaling pathway in human degenerated NP cells. publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2018.01.154 contributor: fullname: Wang – volume: 2021 start-page: 5584447 year: 2021 ident: 2022040512190131600_CIT0005 article-title: Autophagic degradation of Gasdermin D protects against nucleus Pulposus cell Pyroptosis and retards Intervertebral disc degeneration in vivo. publication-title: Oxid Med Cell Longev doi: 10.1155/2021/5584447 contributor: fullname: Liao – volume: 204 start-page: 396 year: 2021 ident: 2022040512190131600_CIT0022 article-title: MiR-223-3p inhibits inflammation and pyroptosis in monosodium urate-induced rats and fibroblast-like synoviocytes by targeting NLRP3. publication-title: Clin Exp Immunol doi: 10.1111/cei.13587 contributor: fullname: Tian – volume: 15 start-page: 89 year: 2017 ident: 2022040512190131600_CIT0018 article-title: MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associated with decreased risk of persistent pain after lumbar disc herniation. publication-title: J Transl Med doi: 10.1186/s12967-017-1194-8 contributor: fullname: Moen – volume: 42 start-page: 245 year: 2017 ident: 2022040512190131600_CIT0039 article-title: Pyroptosis: gasdermin-mediated programmed necrotic cell death. publication-title: Trends Biochem Sci doi: 10.1016/j.tibs.2016.10.004 contributor: fullname: Shi – volume: 40 start-page: 317 year: 2021 ident: 2022040512190131600_CIT0026 article-title: An lncRNA-miRNA-mRNA-ceRNA network regulates intervertebral disc degeneration: a bioinformatics study based on the dataset analysis. publication-title: Gen Physiol Biophys doi: 10.4149/gpb_2021013 contributor: fullname: Fan – volume: 28 start-page: 653 year: 2020 ident: 2022040512190131600_CIT0031 article-title: MicroRNA 223 3p negatively regulates the NLRP3 inflammasome in acute and chronic liver injury. publication-title: Mol Ther doi: 10.1016/j.ymthe.2019.09.013 contributor: fullname: Jimenez Calvente – volume: 12 start-page: 5449 year: 2020 ident: 2022040512190131600_CIT0009 article-title: LncRNA TUG1 promotes the intervertebral disc degeneration and nucleus pulposus cell apoptosis though modulating miR-26a/HMGB1 axis and regulating NF-κB activation. publication-title: Am J Transl Res contributor: fullname: Tang – volume: 20 start-page: 251 year: 2018 ident: 2022040512190131600_CIT0036 article-title: The inflammatory response in the regression of lumbar disc herniation. publication-title: Arthritis Res Ther doi: 10.1186/s13075-018-1743-4 contributor: fullname: Cunha – volume: 24 start-page: 11742 year: 2020 ident: 2022040512190131600_CIT0042 article-title: Mesenchymal stem cells-derived exosomes ameliorate intervertebral disc degeneration through inhibiting pyroptosis. publication-title: J Cell Mol Med doi: 10.1111/jcmm.15784 contributor: fullname: Zhang – volume: 505 start-page: 344 year: 2014 ident: 2022040512190131600_CIT0023 article-title: The multilayered complexity of ceRNA crosstalk and competition. publication-title: Nature doi: 10.1038/nature12986 contributor: fullname: Tay – volume: 18 start-page: 777 year: 2013 ident: 2022040512190131600_CIT0038 article-title: Cell death in intervertebral disc degeneration. publication-title: Apoptosis doi: 10.1007/s10495-013-0839-1 contributor: fullname: Ding – volume: 75 start-page: 467 year: 2018 ident: 2022040512190131600_CIT0033 article-title: Interaction and cross-talk between non-coding RNAs. publication-title: Cell Mol Life Sci doi: 10.1007/s00018-017-2626-6 contributor: fullname: Yamamura – volume: 12 start-page: 7534 year: 2020 ident: 2022040512190131600_CIT0028 article-title: Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells. publication-title: Aging (Albany NY) doi: 10.18632/aging.103109 contributor: fullname: Bai – volume: 11 start-page: 1043 year: 2020 ident: 2022040512190131600_CIT0030 article-title: LncRNA kcnq1ot1 promotes lipid accumulation and accelerates atherosclerosis via functioning as a ceRNA through the miR-452-3p/HDAC3/ABCA1 axis. publication-title: Cell Death Dis doi: 10.1038/s41419-020-03263-6 contributor: fullname: Yu – volume: 54 start-page: e12941 year: 2021 ident: 2022040512190131600_CIT0047 article-title: Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration. publication-title: Cell Prolif doi: 10.1111/cpr.12941 contributor: fullname: Zhao – volume: 38 start-page: 133 year: 2019 ident: 2022040512190131600_CIT0050 article-title: The miR155HG/miR-185/ANXA2 loop contributes to glioblastoma growth and progression. publication-title: J Exp Clin Cancer Res doi: 10.1186/s13046-019-1132-0 contributor: fullname: Wu – volume: 12 start-page: 11025 year: 2020 ident: 2022040512190131600_CIT0021 article-title: LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-223-3p/NLRP3 axis. publication-title: Aging (Albany NY) doi: 10.18632/aging.103314 contributor: fullname: Ren – volume: 526 start-page: 772 year: 2020 ident: 2022040512190131600_CIT0043 article-title: Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell pyroptosis via NLRP3-dependent pathway. publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2020.03.161 contributor: fullname: He – volume: 32 start-page: 21 year: 2021 ident: 2022040512190131600_CIT0035 article-title: Inflammation in the intervertebral disc herniation. publication-title: Neurocirugia (Astur: Engl Ed) doi: 10.1016/j.neucir.2020.01.001 contributor: fullname: Cosamalón-Gan – volume: 17 start-page: 272 year: 2016 ident: 2022040512190131600_CIT0049 article-title: Endogenous microRNA sponges: evidence and controversy. publication-title: Nat Rev Genet doi: 10.1038/nrg.2016.20 contributor: fullname: Thomson |
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| Snippet | Nucleus pulposus (NP) cell pyroptosis plays a critical role in the pathogenesis of intervertebral disk degeneration (IDD). MIR155 host gene (MIR155HG) is a... Abstract Nucleus pulposus (NP) cell pyroptosis plays a critical role in the pathogenesis of intervertebral disk degeneration (IDD). MIR155 host gene (MIR155HG)... |
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| SubjectTerms | Humans Intervertebral Disc Degeneration - genetics Intervertebral Disc Degeneration - metabolism Intervertebral Disc Degeneration - pathology MicroRNAs - genetics Nucleus Pulposus - metabolism Nucleus Pulposus - pathology Pyroptosis - genetics RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism |
| Title | LncRNA MIR155HG functions as a ceRNA of miR-223-3p to promote cell pyroptosis in human degenerative NP cells |
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