Increased risk of pyogenic liver abscess in patients with alcohol intoxication: A population-based retrospective cohort study

• Published in: Alcohol (Fayetteville, N.Y.) Vol. 64; pp. 23 - 28
• Main Authors: Wang, Yao-Chien, Yang, Kai-Wei, Lee, Tien-Ying Peter, Lin, Cheng-Li, Liaw, Geng-Wang, Hung, Dong-Zong, Kao, Chia-Hung, Chen, Wei-Kung, Yang, Tse-Yen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2017; Elsevier Limited
• Subjects: Abscesses; Adult; Alcohol intoxication; Alcohol use; Alcoholic Intoxication - diagnosis; Alcoholic Intoxication - epidemiology; Alcoholism; Cohort analysis; Cohort Studies; Female; Follow-Up Studies; Health insurance; Humans; Intoxication; Liver; Liver Abscess, Pyogenic - diagnosis; Liver Abscess, Pyogenic - epidemiology; Male; Middle Aged; National health insurance research database; Population studies; Population Surveillance; Population-based cohort; Population-based studies; Pyogenic liver abscess; Retrospective Studies; Risk Factors; Taiwan - epidemiology; Young Adult; Taiwan; PLA; CI; AI; HRs; Population-based cohort; aHR; NHIRD; NHI; SD; BNHI; ICD-9-CM; National health insurance research database; Alcohol intoxication; Pyogenic liver abscess; COPD
• ISSN: 0741-8329; 1873-6823; 1873-6823
• DOI: 10.1016/j.alcohol.2017.05.003

We designed a population-based retrospective cohort study to investigate the association between the event of alcohol intoxication and the risk of pyogenic liver abscess. The present study enrolled 245,076 patients with a history of alcohol intoxication from 2000 to 2010 and matched each of them with four comparison patients, with similar mean age and sex ratios. We determined the cumulative incidences and adjusted hazard ratios (aHRs) of liver abscess. A significant association was observed between alcohol intoxication and liver abscess. The incidence density rate of liver abscess was 3.47-fold greater in the alcohol intoxication (AI) cohort than in the non-AI cohort (12.2 vs. 3.43 per 10,000 person-years), with an adjusted HR (aHR) of 2.64 (95% CI = 2.26 to 3.08). This population-based study positively associated the event of alcohol intoxication with increased risk of liver abscess. Our findings warrant further large-scale and in-depth investigations in this area. •The purpose of the study was to assess the alcohol intoxication-related pyogenic liver abscess (PLA) risk.•Alcohol intoxication-related PLA exhibited a higher cumulative incidence rate as 12.2 per 10,000 person-years.•Alcohol intoxication-related risk for PLA was approximately 3.47-fold, as compared to controls.•After comorbidities were adjusted for age and gender, the adjusted risk of PLA was 2.64.•Severe alcoholism will elevate the risks for liver diseases, such as PLA.