Association between hearing loss and physical performance in patients on maintenance hemodialysis

• Published in: Kidney research and clinical practice Vol. 43; no. 3; pp. 358 - 368
• Main Authors: Fan, Weifeng, Zhong, Xiaojing, Wu, Qing, Zhang, Lihong, Yang, Zhenhao, Gu, Yong, Guo, Qi, Chen, Xiaoyu, Yu, Chen, Zhang, Kun, Ding, Wei, Qi, Hualin, Zhao, Junli, Zhang, Liming, Zhang, Suhua, Niu, Jianying
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Nephrology 01.05.2024; 대한신장학회
• Subjects: gait speed; handgrip strength; hearing loss; hemodialysis; Original; physical performance; 내과학; Gait speed; Handgrip strength; Physical performance; Hemodialysis; Hearing loss
• ISSN: 2211-9132; 2211-9140
• DOI: 10.23876/j.krcp.22.231

The correlation between hearing loss (HL) and physical performance in patients receiving maintenance hemodialysis (MHD) remains poorly investigated. This study explored the association between HL and physical performance in patients on MHD. This multicenter cross-sectional study was conducted between July 2020 and April 2021 in seven hemodialysis centers in Shanghai and Suzhou, China. The hearing assessment was performed using pure-tone average (PTA). Physical performance was assessed using the Timed Up and Go Test (TUGT), handgrip strength, and gait speed. Finally, 838 adult patients (male, 516 [61.6%]; 61.2 ± 2.6 years) were enrolled. Among them, 423 (50.5%) had mild to profound HL (male, 48.6% and female, 53.4%). Patients with HL had poorer physical performance than patients without HL (p < 0.001). TUGT was positively correlated with PTA (r = 0.265, p < 0.001), while handgrip strength and gait speed were negatively correlated with PTA (r = -0.356, p < 0.001 and r = -0.342, p < 0.001, respectively). Physical performance in patients aged <60 years showed significant dose-response relationships with HL. After adjusting for confounders, the odds ratios (95% confidence intervals) for HL across the TUGT quartiles (lowest to highest) were 1.00 (reference), 1.15 (0.73-1.81), 1.69 (1.07-2.70), and 2.87 (1.69-4.88) (p for trend = 0.005). Lower prevalence of HL was associated with a faster TUGT and a stronger handgrip strength in patients on MHD.