New aspects in celiac disease

• Published in: World journal of gastroenterology : WJG Vol. 13; no. 8; pp. 1156 - 1161
• Main Author: Torres, MI
• Format: Journal Article
• Language: English
• Published: United States Department of Experimental Biology, University of Jaén, Jaén 23071, Spain%Department of Gastroenterology Pediatrics.Hospital Virgen de las Nieves, Granada%Department Cell Biology. University of Granada, Granada 28.02.2007; Baishideng Publishing Group Co., Limited
• Subjects: Celiac Disease - diagnosis; Celiac Disease - epidemiology; Celiac Disease - immunology; Cytokines - immunology; Europe - epidemiology; Histocompatibility Antigens Class I - immunology; HLA Antigens - immunology; HLA-G Antigens; Humans; Immune Tolerance; Prevalence; United States - epidemiology; 乳糜泻; 口服耐受; 流行性; 麸质不耐受; United States; Europe; Celiac disease; TGF-beta; Gluten intolerance; Oral tolerance; IL-10
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v13.i8.1156

Celiac disease （CD） is a common autoimmune disorder characterized by an immune response to ingested gluten and has a strong HLA association with HLA-DQ2 and HLA-DQ8 molecules, but human HLA-DQ risk factors do not explain the entire genetic susceptibility to gluten intolerance. CD is caused by the lack of immune tolerance （oral tolerance） to wheat gluten. In this sense, the expression of soluble HLA-G in CD is of special interest because the molecule plays an important role in the induction of immune tolerance. The enhanced expression of soluble HLA-G found in CD may be part of a mechanism to restore the gluten intolerance. In this editorial, we review recent progress in understanding CD in relation to its prevalence, diagnosis and possible mechanisms of pathogenesis.