Gastrointestinal Mast Cell Tumor in an African Dormouse (Graphiurus sp.)

Mast cell tumors (MCTs) are well-known neoplasms derived from either mucosal or connective tissue mast cells. While well studied in several domestic species, MCTs are rarely documented in rodents. A three-year-old, male African dormouse (Graphiurus sp.) presented with a history of vomiting and anore...

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Published inVeterinary sciences Vol. 9; no. 9; p. 497
Main Authors Chang, Yen-Chi, Chang, Jung-Chin, Chen, Jo-Wen, Wu, Ying-Chen, Chen, Ter-Hsin
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 11.09.2022
MDPI
Subjects
Anorexia
Blue stain
Case Report
case studies
CD117
Cell proliferation
Connective tissues
eosinophils
Gastric mucosa
Gliridae
granulation tissue
Granule cells
Graphiurus
Graphiurus sp
histology
histopathology
immune response
immunohistopathology
Immunoreactivity
Laboratory animals
Leukocytes (eosinophilic)
Lymphocytes
Lymphoma
males
mast cell tumor
Mast cells
Medical treatment
Necropsy
Neoplasia
neoplasms
Neuroendocrine tumors
Patients
Pets
Rodents
Spleen
Toluidine
toluidine blue
Tumor cells
ultrasonography
Vomiting
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Summary:Mast cell tumors (MCTs) are well-known neoplasms derived from either mucosal or connective tissue mast cells. While well studied in several domestic species, MCTs are rarely documented in rodents. A three-year-old, male African dormouse (Graphiurus sp.) presented with a history of vomiting and anorexia for 3 months. Sonography revealed thickened gastric mucosa and hyperperistalsis. The patient died after receiving symptomatic treatment for 2 months. At necropsy, locally extensive, pale, thickened mucosal foci obscuring the first half of the stomach lumen was noted. Histological examination revealed moderately polymorphic, round, oval to spindle cells with amphophilic cytoplasmic granules infiltrating the mucosa to tunica muscularis, with moderate numbers of eosinophils. The mucosa was severely ulcerated with the proliferation of granulation tissue. The granules in most tumor cells exhibited metachromasia with the toluidine blue stain. Neoplastic cells revealed positive membranous immunoreactivity to KIT. Herein, we report the first case report of MCT in dormouse but also the first gastrointestinal MCT in a rodent species.
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ISSN:2306-7381
2306-7381
DOI:10.3390/vetsci9090497