The Impact of Cancer Stem Cells in Colorectal Cancer

Despite incessant research, colorectal cancer (CRC) is still one of the most common causes of fatality in both men and women worldwide. Over time, advancements in medical treatments have notably enhanced the survival rates of patients with colorectal cancer. Managing metastatic CRC involves a comple...

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Published inInternational journal of molecular sciences Vol. 25; no. 8; p. 4140
Main Authors Radu, Petru, Zurzu, Mihai, Tigora, Anca, Paic, Vlad, Bratucu, Mircea, Garofil, Dragos, Surlin, Valeriu, Munteanu, Alexandru Claudiu, Coman, Ionut Simion, Popa, Florian, Strambu, Victor, Ramboiu, Sandu
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.04.2024
Subjects
Animals
cancer stem cells
Cancer therapies
Chemotherapy
Colorectal cancer
colorectal cancer stem cells
Colorectal Neoplasms - pathology
Development and progression
Disease prevention
Drug resistance
Drug Resistance, Neoplasm
Homeopathy
Humans
Hypotheses
Materia medica and therapeutics
Medical research
Metastasis
Mortality
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
signaling pathways
Stem cells
Therapeutics
Tumors
Romania
colorectal cancer
signaling pathways
cancer stem cells
colorectal cancer stem cells
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Summary:Despite incessant research, colorectal cancer (CRC) is still one of the most common causes of fatality in both men and women worldwide. Over time, advancements in medical treatments have notably enhanced the survival rates of patients with colorectal cancer. Managing metastatic CRC involves a complex tradeoff between the potential benefits and adverse effects of treatment, considering factors like disease progression, treatment toxicity, drug resistance, and the overall impact on the patient's quality of life. An increasing body of evidence highlights the significance of the cancer stem cell (CSC) concept, proposing that CSCs occupy a central role in triggering cancer. CSCs have been a focal point of extensive research in a variety of cancer types, including CRC. Colorectal cancer stem cells (CCSCs) play a crucial role in tumor initiation, metastasis, and therapy resistance, making them potential treatment targets. Various methods exist for isolating CCSCs, and understanding the mechanisms of drug resistance associated with them is crucial. This paper offers an overview of the current body of research pertaining to the comprehension of CSCs in colorectal cancer.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25084140