First-Generation Autologous Chondrocyte Implantation in Patients With Cartilage Defects of the Knee: 7 to 14 Years' Clinical and Magnetic Resonance Imaging Follow-up Evaluation

Purpose The purpose of this study was to evaluate the overall long-term improvement of autologous chondrocyte implantation (ACI) treatment in terms of patient satisfaction, clinical assessment, and magnetic resonance imaging (MRI) evaluation. Furthermore, we aimed to assess the impact of independent...

Full description

Saved in:
Bibliographic Details
Published inArthroscopy Vol. 28; no. 12; pp. 1851 - 1861
Main Authors Moradi, Babak, M.D, Schönit, Eva, M.D, Nierhoff, Corinna, M.D, Hagmann, Sébastien, M.D, Oberle, Doris, M.D., Ph.D, Gotterbarm, Tobias, M.D, Schmitt, Holger, M.D., Ph.D, Zeifang, Felix, M.D., Ph.D
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.12.2012
Elsevier
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Purpose The purpose of this study was to evaluate the overall long-term improvement of autologous chondrocyte implantation (ACI) treatment in terms of patient satisfaction, clinical assessment, and magnetic resonance imaging (MRI) evaluation. Furthermore, we aimed to assess the impact of independent variables on clinical outcomes and patient satisfaction. Methods We evaluated 23 patients (mean age, 30.5 ± 8.2 years) with full-thickness chondral lesions of the distal femur who underwent first-generation ACI with periosteum between 1997 and 2004. The Lysholm score, Tegner activity score, subjective International Knee Documentation Committee score, numeric rating scale score, and Short Form 36 score were used for clinical assessment preoperatively, at 1 year postoperatively, and at 7 to 14 years (mean, 9.9 years) after surgery. MRI was performed to evaluate the cartilage preoperatively and at final follow-up, by use of the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score. Results ACI resulted in a substantial improvement in all clinical outcome parameters, even as much as 14 years after implantation, although a small deterioration was noticed between intermediate and final evaluations in some outcome parameters. Of the patients, 73.1% stated that they would undergo the operation again. Younger patients with a shorter duration of preoperative symptoms and smaller defect sizes benefited most. MRI findings confirmed complete defect filling in 52.3% of the patients at final follow-up. Conclusions Our long-term results confirm that first-generation ACI is an effective treatment for large full-thickness chondral and osteochondral lesions of the knee joint. Younger patients with a shorter duration of preoperative symptoms and smaller defect size benefited most in our study. Level of Evidence Level IV, therapeutic case series.
AbstractList Purpose The purpose of this study was to evaluate the overall long-term improvement of autologous chondrocyte implantation (ACI) treatment in terms of patient satisfaction, clinical assessment, and magnetic resonance imaging (MRI) evaluation. Furthermore, we aimed to assess the impact of independent variables on clinical outcomes and patient satisfaction. Methods We evaluated 23 patients (mean age, 30.5 ± 8.2 years) with full-thickness chondral lesions of the distal femur who underwent first-generation ACI with periosteum between 1997 and 2004. The Lysholm score, Tegner activity score, subjective International Knee Documentation Committee score, numeric rating scale score, and Short Form 36 score were used for clinical assessment preoperatively, at 1 year postoperatively, and at 7 to 14 years (mean, 9.9 years) after surgery. MRI was performed to evaluate the cartilage preoperatively and at final follow-up, by use of the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score. Results ACI resulted in a substantial improvement in all clinical outcome parameters, even as much as 14 years after implantation, although a small deterioration was noticed between intermediate and final evaluations in some outcome parameters. Of the patients, 73.1% stated that they would undergo the operation again. Younger patients with a shorter duration of preoperative symptoms and smaller defect sizes benefited most. MRI findings confirmed complete defect filling in 52.3% of the patients at final follow-up. Conclusions Our long-term results confirm that first-generation ACI is an effective treatment for large full-thickness chondral and osteochondral lesions of the knee joint. Younger patients with a shorter duration of preoperative symptoms and smaller defect size benefited most in our study. Level of Evidence Level IV, therapeutic case series.
PURPOSEThe purpose of this study was to evaluate the overall long-term improvement of autologous chondrocyte implantation (ACI) treatment in terms of patient satisfaction, clinical assessment, and magnetic resonance imaging (MRI) evaluation. Furthermore, we aimed to assess the impact of independent variables on clinical outcomes and patient satisfaction.METHODSWe evaluated 23 patients (mean age, 30.5 ± 8.2 years) with full-thickness chondral lesions of the distal femur who underwent first-generation ACI with periosteum between 1997 and 2004. The Lysholm score, Tegner activity score, subjective International Knee Documentation Committee score, numeric rating scale score, and Short Form 36 score were used for clinical assessment preoperatively, at 1 year postoperatively, and at 7 to 14 years (mean, 9.9 years) after surgery. MRI was performed to evaluate the cartilage preoperatively and at final follow-up, by use of the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score.RESULTSACI resulted in a substantial improvement in all clinical outcome parameters, even as much as 14 years after implantation, although a small deterioration was noticed between intermediate and final evaluations in some outcome parameters. Of the patients, 73.1% stated that they would undergo the operation again. Younger patients with a shorter duration of preoperative symptoms and smaller defect sizes benefited most. MRI findings confirmed complete defect filling in 52.3% of the patients at final follow-up.CONCLUSIONSOur long-term results confirm that first-generation ACI is an effective treatment for large full-thickness chondral and osteochondral lesions of the knee joint. Younger patients with a shorter duration of preoperative symptoms and smaller defect size benefited most in our study.LEVEL OF EVIDENCELevel IV, therapeutic case series.
The purpose of this study was to evaluate the overall long-term improvement of autologous chondrocyte implantation (ACI) treatment in terms of patient satisfaction, clinical assessment, and magnetic resonance imaging (MRI) evaluation. Furthermore, we aimed to assess the impact of independent variables on clinical outcomes and patient satisfaction. We evaluated 23 patients (mean age, 30.5 ± 8.2 years) with full-thickness chondral lesions of the distal femur who underwent first-generation ACI with periosteum between 1997 and 2004. The Lysholm score, Tegner activity score, subjective International Knee Documentation Committee score, numeric rating scale score, and Short Form 36 score were used for clinical assessment preoperatively, at 1 year postoperatively, and at 7 to 14 years (mean, 9.9 years) after surgery. MRI was performed to evaluate the cartilage preoperatively and at final follow-up, by use of the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score. ACI resulted in a substantial improvement in all clinical outcome parameters, even as much as 14 years after implantation, although a small deterioration was noticed between intermediate and final evaluations in some outcome parameters. Of the patients, 73.1% stated that they would undergo the operation again. Younger patients with a shorter duration of preoperative symptoms and smaller defect sizes benefited most. MRI findings confirmed complete defect filling in 52.3% of the patients at final follow-up. Our long-term results confirm that first-generation ACI is an effective treatment for large full-thickness chondral and osteochondral lesions of the knee joint. Younger patients with a shorter duration of preoperative symptoms and smaller defect size benefited most in our study. Level IV, therapeutic case series.
Author Moradi, Babak, M.D
Zeifang, Felix, M.D., Ph.D
Schönit, Eva, M.D
Hagmann, Sébastien, M.D
Gotterbarm, Tobias, M.D
Schmitt, Holger, M.D., Ph.D
Nierhoff, Corinna, M.D
Oberle, Doris, M.D., Ph.D
Author_xml – sequence: 1
  fullname: Moradi, Babak, M.D
– sequence: 2
  fullname: Schönit, Eva, M.D
– sequence: 3
  fullname: Nierhoff, Corinna, M.D
– sequence: 4
  fullname: Hagmann, Sébastien, M.D
– sequence: 5
  fullname: Oberle, Doris, M.D., Ph.D
– sequence: 6
  fullname: Gotterbarm, Tobias, M.D
– sequence: 7
  fullname: Schmitt, Holger, M.D., Ph.D
– sequence: 8
  fullname: Zeifang, Felix, M.D., Ph.D
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26701254$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/23036160$$D View this record in MEDLINE/PubMed
BookMark eNqFkstuEzEUhkeoiF7gDRDyBsFmgu_jsECqQlMqikBcBKwsj-dM4nRiB9tTlLfiEXFIAIkNK1vWdy76P59WRz54qKqHBE8IJvLZamJiXsYwoZjQCRYTpdid6oQIKmtGGTmqTnDDp7XCkh1XpymtMMaMKXavOqYMM0kkPql-zF1Mub4ED9FkFzw6H3MYwiKMCc2WwXcx2G0GdLXeDMbnPeM8eldu4HNCn11eolnZxQ1mAegl9GDLc-hRXgJ67QGeowblgAhHX8HE9ATNBuedNQMyvkNvzMJDdha9hxS88XY3yyycX6B5GIbwvR436OLWDOOv2feru70ZEjw4nGfVp_nFx9mr-vrt5dXs_Lq2nDe5NrRToqWtYLhrbcuolXbacN62rZXcEi6YFD0w1YtWSDltjVAdVU2HadNPccPOqqf7vpsYvo2Qsl67ZGEoIUDJRhNKiRLNVMmC8j1qY0gpQq830a1N3GqC9c6VXum9K71zpbHQxVUpe3SYMLZr6P4U_ZZTgMcHwKSSVh9LOC795WRTugleuBd7Dkoetw6iTra4sdC5WFzoLrj_bfJvA3swdANbSKswRl-y1kSnUqM_7P7V7luR0oRz9YX9BONFzLM
CODEN ARTHE3
CitedBy_id crossref_primary_10_1016_j_reth_2018_10_002
crossref_primary_10_1177_1947603520958146
crossref_primary_10_1177_0363546514536682
crossref_primary_10_1016_j_jcjp_2023_100150
crossref_primary_10_1302_2046_3758_28_2000184
crossref_primary_10_1016_j_csm_2013_08_008
crossref_primary_10_2106_JBJS_CC_23_00281
crossref_primary_10_1007_s43465_023_00989_1
crossref_primary_10_1016_j_injury_2017_08_005
crossref_primary_10_1007_s10195_015_0383_6
crossref_primary_10_1155_2014_370621
crossref_primary_10_1016_j_joca_2014_12_021
crossref_primary_10_1136_jisakos_2015_000037
crossref_primary_10_1016_j_arthro_2014_11_023
crossref_primary_10_1177_1947603516630786
crossref_primary_10_1055_s_0041_1735278
crossref_primary_10_1177_0363546517716631
crossref_primary_10_1016_j_joca_2014_03_014
crossref_primary_10_1177_0363546513506593
crossref_primary_10_1007_s00264_014_2368_0
crossref_primary_10_1177_0363546519834557
crossref_primary_10_1097_JSA_0000000000000137
crossref_primary_10_3810_psm_2013_05_2017
crossref_primary_10_1088_1748_605X_ac094b
crossref_primary_10_1016_j_arthro_2016_03_007
crossref_primary_10_1002_jbm_a_36467
crossref_primary_10_1007_s00167_015_3822_2
crossref_primary_10_1007_s00167_013_2778_3
crossref_primary_10_1016_j_jcjp_2021_100010
crossref_primary_10_1177_1941738115611350
crossref_primary_10_1177_0363546518756977
crossref_primary_10_1007_s10856_015_5517_0
crossref_primary_10_1177_0363546519876630
crossref_primary_10_1177_0363546519871064
crossref_primary_10_1007_s00264_017_3434_1
crossref_primary_10_1016_j_csm_2014_01_004
crossref_primary_10_5966_sctm_2016_0004
crossref_primary_10_1177_1947603519841673
crossref_primary_10_1016_j_arthro_2020_05_004
crossref_primary_10_1177_0363546514548160
crossref_primary_10_1177_0363546518824552
crossref_primary_10_1007_s00256_021_03775_y
crossref_primary_10_2106_JBJS_RVW_17_00005
crossref_primary_10_1007_s00264_022_05581_0
crossref_primary_10_1007_s00393_013_1319_2
crossref_primary_10_1016_j_drudis_2019_07_010
crossref_primary_10_1007_s00132_012_2044_2
crossref_primary_10_1177_1947603519865308
crossref_primary_10_1177_0363546520928337
crossref_primary_10_1016_j_tibtech_2014_11_003
crossref_primary_10_1007_s12178_014_9254_7
crossref_primary_10_1016_j_eats_2014_02_012
crossref_primary_10_1016_j_mric_2014_07_008
crossref_primary_10_2106_JBJS_20_01399
crossref_primary_10_1016_j_arthro_2020_03_009
Cites_doi 10.1177/0363546509348000
10.2106/00004623-200300002-00003
10.1177/03635465980260062201
10.1097/00003086-200507000-00036
10.1177/036354658201000306
10.1016/j.ejrad.2005.08.007
10.1177/0363546509357915
10.1177/0363546505275148
10.1177/0363546508330149
10.2106/00004623-200300002-00002
10.1177/03635465010290051301
10.1177/03635465020300011601
10.1007/BF01560215
10.1177/0363546509332258
10.2106/JBJS.J.00049
10.1016/j.ejrad.2004.03.014
10.1177/0363546509351499
10.1053/jars.2003.50112
10.1177/0363546508323256
10.2106/00004623-200710000-00002
10.1007/s001030050036
10.2106/00004623-200302000-00001
10.1302/0301-620X.43B4.752
10.2106/00004623-200611000-00025
10.1177/0363546511422220
10.1177/0363546508328414
10.1302/0301-620X.87B5.15905
10.1056/NEJM199410063311401
10.1177/0363546509358266
10.1097/00003086-200209000-00009
10.1186/ar2638
ContentType Journal Article
Copyright Arthroscopy Association of North America
2012 Arthroscopy Association of North America
2014 INIST-CNRS
Copyright © 2012 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.
Copyright_xml – notice: Arthroscopy Association of North America
– notice: 2012 Arthroscopy Association of North America
– notice: 2014 INIST-CNRS
– notice: Copyright © 2012 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.1016/j.arthro.2012.05.883
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
EISSN 1526-3231
EndPage 1861
ExternalDocumentID 10_1016_j_arthro_2012_05_883
23036160
26701254
S074980631201448X
1_s2_0_S074980631201448X
Genre Evaluation Studies
Journal Article
GroupedDBID --K
.1-
.FO
.GJ
0R~
1B1
1P~
1RT
1~5
3O-
4.4
457
4G.
53G
5RE
5VS
7-5
AAEDT
AAEDW
AALRI
AAQFI
AAQQT
AAQXK
AAXUO
ABLJU
ABMAC
ADBBV
ADMUD
ADPAM
AEVXI
AFCTW
AFJKZ
AFRHN
AFTJW
AHHHB
AITUG
AJUYK
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ASPBG
AVWKF
AZFZN
BELOY
C5W
CAG
COF
EBS
EFJIC
EJD
F5P
FDB
FEDTE
FGOYB
G-2
GBLVA
HEE
HEK
HMK
HMO
HVGLF
HZ~
IHE
J1W
KOM
M28
M31
M41
MO0
N9A
NQ-
O9-
OF~
OR-
R2-
RIG
ROL
RPZ
SAE
SEL
SES
SEW
SJN
SSZ
UHS
UV1
WUQ
XH2
YCJ
Z5R
ZXP
AAIAV
AGZHU
ALXNB
ZA5
08R
ABFLS
IPNFZ
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
ACRPL
ADNMO
CITATION
7X8
ID FETCH-LOGICAL-c447t-a2d85b2b530dbcb32c6c9744bbbc64c145365fe38f5b5669ba58d287d027f9073
ISSN 0749-8063
IngestDate Fri Aug 16 23:57:22 EDT 2024
Fri Dec 06 02:56:34 EST 2024
Sat Sep 28 08:06:37 EDT 2024
Fri Nov 25 01:04:02 EST 2022
Fri Feb 23 02:21:44 EST 2024
Tue Oct 15 22:56:57 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 12
Keywords Knee
Human
Cartilage
Autograft
Chondrocyte implantation
Arthroscopy
Orthopedic surgery
Treatment
Medical imagery
Endoscopy
Nuclear magnetic resonance imaging
Language English
License CC BY 4.0
Copyright © 2012 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c447t-a2d85b2b530dbcb32c6c9744bbbc64c145365fe38f5b5669ba58d287d027f9073
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 23036160
PQID 1221857986
PQPubID 23479
PageCount 11
ParticipantIDs proquest_miscellaneous_1221857986
crossref_primary_10_1016_j_arthro_2012_05_883
pubmed_primary_23036160
pascalfrancis_primary_26701254
elsevier_sciencedirect_doi_10_1016_j_arthro_2012_05_883
elsevier_clinicalkeyesjournals_1_s2_0_S074980631201448X
PublicationCentury 2000
PublicationDate 2012-12-01
PublicationDateYYYYMMDD 2012-12-01
PublicationDate_xml – month: 12
  year: 2012
  text: 2012-12-01
  day: 01
PublicationDecade 2010
PublicationPlace New York, NY
PublicationPlace_xml – name: New York, NY
– name: United States
PublicationTitle Arthroscopy
PublicationTitleAlternate Arthroscopy
PublicationYear 2012
Publisher Elsevier Inc
Elsevier
Publisher_xml – name: Elsevier Inc
– name: Elsevier
References Vanlauwe, Saris, Victor (bib29) 2011; 39
Moseley, Anderson, Browne (bib13) 2010; 38
Irrgang, Anderson, Boland (bib22) 2001; 29
Mithoefer, McAdams, Williams, Kreuz, Mandelbaum (bib31) 2009; 37
Brittberg, Lindahl, Nilsson, Ohlsson, Isaksson, Peterson (bib2) 1994; 331
Steadman, Briggs, Rodrigo, Kocher, Gill, Rodkey (bib32) 2003; 19
Knutsen, Drogset, Engebretsen (bib8) 2007; 89
Marlovits, Singer, Zeller, Mandl, Haller, Trattnig (bib23) 2006; 57
Peterson, Brittberg, Kiviranta, Akerlund, Lindahl (bib5) 2002; 30
Mandelbaum, Browne, Fu (bib1) 1998; 26
Horas, Pelinkovic, Herr, Aigner, Schnettler (bib7) 2003; 85
Vasiliadis, Danielson, Ljungberg, McKeon, Lindahl, Peterson (bib27) 2010; 38
Lysholm, Gillquist (bib21) 1982; 10
Briggs, Steadman, Hay, Hines (bib25) 2009; 37
Fu, Zurakowski, Browne (bib10) 2005; 33
Bellach (bib18) 2000; 43
Harris, Siston, Pan, Flanigan (bib28) 2010; 92
Outerbridge (bib14) 1961; 43
Bartlett, Skinner, Gooding (bib24) 2005; 87
Hefti, Müller, Jakob, Stäubli (bib17) 1993; 1
Marlovits, Striessnig, Resinger (bib20) 2004; 52
McNickle, L'Heureux, Yanke, Cole (bib11) 2009; 37
Zeifang, Oberle, Nierhoff, Richter, Moradi, Schmitt (bib19) 2010; 38
Kreuz, Müller, Ossendorf, Kaps, Erggelet (bib4) 2009; 11
Peterson, Minas, Brittberg, Lindahl (bib6) 2003; 85
Kon, Gobbi, Filardo, Delcogliano, Zaffagnini, Marcacci (bib30) 2009; 37
Shelbourne, Jari, Gray (bib26) 2003; 85
Jones, Peterson (bib3) 2006; 88
Browne, Anderson, Arciero (bib9) 2005
Peterson, Vasiliadis, Brittberg, Lindahl (bib12) 2010; 38
Tegner, Lysholm (bib15) 1985
Irrgang, Anderson (bib16) 2002
Fu (10.1016/j.arthro.2012.05.883_bib10) 2005; 33
Outerbridge (10.1016/j.arthro.2012.05.883_bib14) 1961; 43
Marlovits (10.1016/j.arthro.2012.05.883_bib20) 2004; 52
Marlovits (10.1016/j.arthro.2012.05.883_bib23) 2006; 57
Vasiliadis (10.1016/j.arthro.2012.05.883_bib27) 2010; 38
Knutsen (10.1016/j.arthro.2012.05.883_bib8) 2007; 89
Mithoefer (10.1016/j.arthro.2012.05.883_bib31) 2009; 37
Horas (10.1016/j.arthro.2012.05.883_bib7) 2003; 85
Lysholm (10.1016/j.arthro.2012.05.883_bib21) 1982; 10
Hefti (10.1016/j.arthro.2012.05.883_bib17) 1993; 1
Peterson (10.1016/j.arthro.2012.05.883_bib12) 2010; 38
Brittberg (10.1016/j.arthro.2012.05.883_bib2) 1994; 331
Moseley (10.1016/j.arthro.2012.05.883_bib13) 2010; 38
Vanlauwe (10.1016/j.arthro.2012.05.883_bib29) 2011; 39
Irrgang (10.1016/j.arthro.2012.05.883_bib22) 2001; 29
Mandelbaum (10.1016/j.arthro.2012.05.883_bib1) 1998; 26
Browne (10.1016/j.arthro.2012.05.883_bib9) 2005
Bellach (10.1016/j.arthro.2012.05.883_bib18) 2000; 43
Peterson (10.1016/j.arthro.2012.05.883_bib6) 2003; 85
Kreuz (10.1016/j.arthro.2012.05.883_bib4) 2009; 11
Briggs (10.1016/j.arthro.2012.05.883_bib25) 2009; 37
Shelbourne (10.1016/j.arthro.2012.05.883_bib26) 2003; 85
Peterson (10.1016/j.arthro.2012.05.883_bib5) 2002; 30
Bartlett (10.1016/j.arthro.2012.05.883_bib24) 2005; 87
Harris (10.1016/j.arthro.2012.05.883_bib28) 2010; 92
Steadman (10.1016/j.arthro.2012.05.883_bib32) 2003; 19
Kon (10.1016/j.arthro.2012.05.883_bib30) 2009; 37
McNickle (10.1016/j.arthro.2012.05.883_bib11) 2009; 37
Tegner (10.1016/j.arthro.2012.05.883_bib15) 1985
Jones (10.1016/j.arthro.2012.05.883_bib3) 2006; 88
Zeifang (10.1016/j.arthro.2012.05.883_bib19) 2010; 38
Irrgang (10.1016/j.arthro.2012.05.883_bib16) 2002
References_xml – volume: 37
  start-page: 33
  year: 2009
  end-page: 41
  ident: bib30
  article-title: Arthroscopic second-generation autologous chondrocyte implantation compared with microfracture for chondral lesions of the knee: Prospective nonrandomized study at 5 years
  publication-title: Am J Sports Med
  contributor:
    fullname: Marcacci
– volume: 38
  start-page: 943
  year: 2010
  end-page: 949
  ident: bib27
  article-title: Autologous chondrocyte implantation in cartilage lesions of the knee: Long-term evaluation with magnetic resonance imaging and delayed gadolinium-enhanced magnetic resonance imaging technique
  publication-title: Am J Sports Med
  contributor:
    fullname: Peterson
– volume: 38
  start-page: 238
  year: 2010
  end-page: 246
  ident: bib13
  article-title: Long-term durability of autologous chondrocyte implantation: A multicenter, observational study in US patients
  publication-title: Am J Sports Med
  contributor:
    fullname: Browne
– volume: 331
  start-page: 889
  year: 1994
  end-page: 895
  ident: bib2
  article-title: Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
  publication-title: N Engl J Med
  contributor:
    fullname: Peterson
– volume: 33
  start-page: 1658
  year: 2005
  end-page: 1666
  ident: bib10
  article-title: Autologous chondrocyte implantation versus debridement for treatment of full-thickness chondral defects of the knee: An observational cohort study with 3-year follow-up
  publication-title: Am J Sports Med
  contributor:
    fullname: Browne
– volume: 38
  start-page: 924
  year: 2010
  end-page: 933
  ident: bib19
  article-title: Autologous chondrocyte implantation using the original periosteum-cover technique versus matrix-associated autologous chondrocyte implantation: A randomized clinical trial
  publication-title: Am J Sports Med
  contributor:
    fullname: Schmitt
– volume: 1
  start-page: 226
  year: 1993
  end-page: 234
  ident: bib17
  article-title: Evaluation of knee ligament injuries with the IKDC form
  publication-title: Knee Surg Sports Traumatol Arthrosc
  contributor:
    fullname: Stäubli
– volume: 10
  start-page: 150
  year: 1982
  end-page: 154
  ident: bib21
  article-title: Evaluation of knee ligament surgery results with special emphasis on use of a scoring scale
  publication-title: Am J Sports Med
  contributor:
    fullname: Gillquist
– volume: 37
  start-page: 2053
  year: 2009
  end-page: 2063
  ident: bib31
  article-title: Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: An evidence-based systematic analysis
  publication-title: Am J Sports Med
  contributor:
    fullname: Mandelbaum
– volume: 57
  start-page: 16
  year: 2006
  end-page: 23
  ident: bib23
  article-title: Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: Determination of interobserver variability and correlation to clinical outcome after 2 years
  publication-title: Eur J Radiol
  contributor:
    fullname: Trattnig
– volume: 43
  start-page: 752
  year: 1961
  end-page: 757
  ident: bib14
  article-title: The etiology of chondromalacia patellae
  publication-title: J Bone Joint Surg Br
  contributor:
    fullname: Outerbridge
– start-page: 43
  year: 1985
  end-page: 49
  ident: bib15
  article-title: Rating systems in the evaluation of knee ligament injuries
  publication-title: Clin Orthop Relat Res
  contributor:
    fullname: Lysholm
– volume: 38
  start-page: 1117
  year: 2010
  end-page: 1124
  ident: bib12
  article-title: Autologous chondrocyte implantation: A long-term follow-up
  publication-title: Am J Sports Med
  contributor:
    fullname: Lindahl
– volume: 37
  start-page: 898
  year: 2009
  end-page: 901
  ident: bib25
  article-title: Lysholm score and Tegner activity level in individuals with normal knees
  publication-title: Am J Sports Med
  contributor:
    fullname: Hines
– volume: 85
  start-page: 17
  year: 2003
  end-page: 24
  ident: bib6
  article-title: Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation: Results at two to ten years
  publication-title: J Bone Joint Surg Am
  contributor:
    fullname: Lindahl
– volume: 29
  start-page: 600
  year: 2001
  end-page: 613
  ident: bib22
  article-title: Development and validation of the international knee documentation committee subjective knee form
  publication-title: Am J Sports Med
  contributor:
    fullname: Boland
– start-page: 237
  year: 2005
  end-page: 245
  ident: bib9
  article-title: Clinical outcome of autologous chondrocyte implantation at 5 years in US subjects
  publication-title: Clin Orthop Relat Res
  contributor:
    fullname: Arciero
– volume: 52
  start-page: 310
  year: 2004
  end-page: 319
  ident: bib20
  article-title: Definition of pertinent parameters for the evaluation of articular cartilage repair tissue with high-resolution magnetic resonance imaging
  publication-title: Eur J Radiol
  contributor:
    fullname: Resinger
– volume: 19
  start-page: 477
  year: 2003
  end-page: 484
  ident: bib32
  article-title: Outcomes of microfracture for traumatic chondral defects of the knee: Average 11-year follow-up
  publication-title: Arthroscopy
  contributor:
    fullname: Rodkey
– volume: 43
  start-page: 210
  year: 2000
  end-page: 216
  ident: bib18
  article-title: Der SF-36 im Bundesgesundheitssurvey—Erste Ergebnisse und neue Fragen
  publication-title: Bundesgesundheitsblatt
  contributor:
    fullname: Bellach
– volume: 85
  start-page: 185
  year: 2003
  end-page: 192
  ident: bib7
  article-title: Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint
  publication-title: J Bone Joint Surg Am
  contributor:
    fullname: Schnettler
– volume: 88
  start-page: 2502
  year: 2006
  end-page: 2520
  ident: bib3
  article-title: Autologous chondrocyte implantation
  publication-title: J Bone Joint Surg Am
  contributor:
    fullname: Peterson
– volume: 89
  start-page: 2105
  year: 2007
  end-page: 2112
  ident: bib8
  article-title: A randomized trial comparing autologous chondrocyte implantation with microfracture
  publication-title: J Bone Joint Surg Am
  contributor:
    fullname: Engebretsen
– volume: 87
  start-page: 640
  year: 2005
  end-page: 645
  ident: bib24
  article-title: Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: A prospective, randomised study
  publication-title: J Bone Joint Surg Br
  contributor:
    fullname: Gooding
– volume: 37
  start-page: 1344
  year: 2009
  end-page: 1350
  ident: bib11
  article-title: Outcomes of autologous chondrocyte implantation in a diverse patient population
  publication-title: Am J Sports Med
  contributor:
    fullname: Cole
– volume: 11
  start-page: R33
  year: 2009
  ident: bib4
  article-title: Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: Four-year clinical results
  publication-title: Arthritis Res Ther
  contributor:
    fullname: Erggelet
– volume: 30
  start-page: 2
  year: 2002
  end-page: 12
  ident: bib5
  article-title: Autologous chondrocyte transplantation
  publication-title: Am J Sports Med
  contributor:
    fullname: Lindahl
– volume: 85
  start-page: 8
  year: 2003
  end-page: 16
  ident: bib26
  article-title: Outcome of untreated traumatic articular cartilage defects of the knee: A natural history study
  publication-title: J Bone Joint Surg Am
  contributor:
    fullname: Gray
– volume: 92
  start-page: 2220
  year: 2010
  end-page: 2233
  ident: bib28
  article-title: Autologous chondrocyte implantation: A systematic review
  publication-title: J Bone Joint Surg Am
  contributor:
    fullname: Flanigan
– volume: 26
  start-page: 853
  year: 1998
  end-page: 861
  ident: bib1
  article-title: Articular cartilage lesions of the knee
  publication-title: Am J Sports Med
  contributor:
    fullname: Fu
– start-page: 95
  year: 2002
  end-page: 109
  ident: bib16
  article-title: Development and validation of health-related quality of life measures for the knee
  publication-title: Clin Orthop Relat Res
  contributor:
    fullname: Anderson
– volume: 39
  start-page: 2566
  year: 2011
  end-page: 2574
  ident: bib29
  article-title: Five-year outcome of characterized chondrocyte implantation versus microfracture for symptomatic cartilage defects of the knee: Early treatment matters
  publication-title: Am J Sports Med
  contributor:
    fullname: Victor
– volume: 38
  start-page: 238
  year: 2010
  ident: 10.1016/j.arthro.2012.05.883_bib13
  article-title: Long-term durability of autologous chondrocyte implantation: A multicenter, observational study in US patients
  publication-title: Am J Sports Med
  doi: 10.1177/0363546509348000
  contributor:
    fullname: Moseley
– volume: 85
  start-page: 17
  issue: Suppl 2
  year: 2003
  ident: 10.1016/j.arthro.2012.05.883_bib6
  article-title: Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation: Results at two to ten years
  publication-title: J Bone Joint Surg Am
  doi: 10.2106/00004623-200300002-00003
  contributor:
    fullname: Peterson
– volume: 26
  start-page: 853
  year: 1998
  ident: 10.1016/j.arthro.2012.05.883_bib1
  article-title: Articular cartilage lesions of the knee
  publication-title: Am J Sports Med
  doi: 10.1177/03635465980260062201
  contributor:
    fullname: Mandelbaum
– start-page: 237
  year: 2005
  ident: 10.1016/j.arthro.2012.05.883_bib9
  article-title: Clinical outcome of autologous chondrocyte implantation at 5 years in US subjects
  publication-title: Clin Orthop Relat Res
  doi: 10.1097/00003086-200507000-00036
  contributor:
    fullname: Browne
– volume: 10
  start-page: 150
  year: 1982
  ident: 10.1016/j.arthro.2012.05.883_bib21
  article-title: Evaluation of knee ligament surgery results with special emphasis on use of a scoring scale
  publication-title: Am J Sports Med
  doi: 10.1177/036354658201000306
  contributor:
    fullname: Lysholm
– volume: 57
  start-page: 16
  year: 2006
  ident: 10.1016/j.arthro.2012.05.883_bib23
  article-title: Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: Determination of interobserver variability and correlation to clinical outcome after 2 years
  publication-title: Eur J Radiol
  doi: 10.1016/j.ejrad.2005.08.007
  contributor:
    fullname: Marlovits
– volume: 38
  start-page: 1117
  year: 2010
  ident: 10.1016/j.arthro.2012.05.883_bib12
  article-title: Autologous chondrocyte implantation: A long-term follow-up
  publication-title: Am J Sports Med
  doi: 10.1177/0363546509357915
  contributor:
    fullname: Peterson
– volume: 33
  start-page: 1658
  year: 2005
  ident: 10.1016/j.arthro.2012.05.883_bib10
  article-title: Autologous chondrocyte implantation versus debridement for treatment of full-thickness chondral defects of the knee: An observational cohort study with 3-year follow-up
  publication-title: Am J Sports Med
  doi: 10.1177/0363546505275148
  contributor:
    fullname: Fu
– volume: 37
  start-page: 898
  year: 2009
  ident: 10.1016/j.arthro.2012.05.883_bib25
  article-title: Lysholm score and Tegner activity level in individuals with normal knees
  publication-title: Am J Sports Med
  doi: 10.1177/0363546508330149
  contributor:
    fullname: Briggs
– volume: 85
  start-page: 8
  issue: Suppl 2
  year: 2003
  ident: 10.1016/j.arthro.2012.05.883_bib26
  article-title: Outcome of untreated traumatic articular cartilage defects of the knee: A natural history study
  publication-title: J Bone Joint Surg Am
  doi: 10.2106/00004623-200300002-00002
  contributor:
    fullname: Shelbourne
– volume: 29
  start-page: 600
  year: 2001
  ident: 10.1016/j.arthro.2012.05.883_bib22
  article-title: Development and validation of the international knee documentation committee subjective knee form
  publication-title: Am J Sports Med
  doi: 10.1177/03635465010290051301
  contributor:
    fullname: Irrgang
– volume: 30
  start-page: 2
  year: 2002
  ident: 10.1016/j.arthro.2012.05.883_bib5
  article-title: Autologous chondrocyte transplantation
  publication-title: Am J Sports Med
  doi: 10.1177/03635465020300011601
  contributor:
    fullname: Peterson
– volume: 1
  start-page: 226
  year: 1993
  ident: 10.1016/j.arthro.2012.05.883_bib17
  article-title: Evaluation of knee ligament injuries with the IKDC form
  publication-title: Knee Surg Sports Traumatol Arthrosc
  doi: 10.1007/BF01560215
  contributor:
    fullname: Hefti
– volume: 37
  start-page: 1344
  year: 2009
  ident: 10.1016/j.arthro.2012.05.883_bib11
  article-title: Outcomes of autologous chondrocyte implantation in a diverse patient population
  publication-title: Am J Sports Med
  doi: 10.1177/0363546509332258
  contributor:
    fullname: McNickle
– volume: 92
  start-page: 2220
  year: 2010
  ident: 10.1016/j.arthro.2012.05.883_bib28
  article-title: Autologous chondrocyte implantation: A systematic review
  publication-title: J Bone Joint Surg Am
  doi: 10.2106/JBJS.J.00049
  contributor:
    fullname: Harris
– volume: 52
  start-page: 310
  year: 2004
  ident: 10.1016/j.arthro.2012.05.883_bib20
  article-title: Definition of pertinent parameters for the evaluation of articular cartilage repair tissue with high-resolution magnetic resonance imaging
  publication-title: Eur J Radiol
  doi: 10.1016/j.ejrad.2004.03.014
  contributor:
    fullname: Marlovits
– volume: 38
  start-page: 924
  year: 2010
  ident: 10.1016/j.arthro.2012.05.883_bib19
  article-title: Autologous chondrocyte implantation using the original periosteum-cover technique versus matrix-associated autologous chondrocyte implantation: A randomized clinical trial
  publication-title: Am J Sports Med
  doi: 10.1177/0363546509351499
  contributor:
    fullname: Zeifang
– volume: 19
  start-page: 477
  year: 2003
  ident: 10.1016/j.arthro.2012.05.883_bib32
  article-title: Outcomes of microfracture for traumatic chondral defects of the knee: Average 11-year follow-up
  publication-title: Arthroscopy
  doi: 10.1053/jars.2003.50112
  contributor:
    fullname: Steadman
– volume: 37
  start-page: 33
  year: 2009
  ident: 10.1016/j.arthro.2012.05.883_bib30
  article-title: Arthroscopic second-generation autologous chondrocyte implantation compared with microfracture for chondral lesions of the knee: Prospective nonrandomized study at 5 years
  publication-title: Am J Sports Med
  doi: 10.1177/0363546508323256
  contributor:
    fullname: Kon
– volume: 89
  start-page: 2105
  year: 2007
  ident: 10.1016/j.arthro.2012.05.883_bib8
  article-title: A randomized trial comparing autologous chondrocyte implantation with microfracture
  publication-title: J Bone Joint Surg Am
  doi: 10.2106/00004623-200710000-00002
  contributor:
    fullname: Knutsen
– volume: 43
  start-page: 210
  year: 2000
  ident: 10.1016/j.arthro.2012.05.883_bib18
  article-title: Der SF-36 im Bundesgesundheitssurvey—Erste Ergebnisse und neue Fragen
  publication-title: Bundesgesundheitsblatt
  doi: 10.1007/s001030050036
  contributor:
    fullname: Bellach
– volume: 85
  start-page: 185
  year: 2003
  ident: 10.1016/j.arthro.2012.05.883_bib7
  article-title: Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint
  publication-title: J Bone Joint Surg Am
  doi: 10.2106/00004623-200302000-00001
  contributor:
    fullname: Horas
– volume: 43
  start-page: 752
  year: 1961
  ident: 10.1016/j.arthro.2012.05.883_bib14
  article-title: The etiology of chondromalacia patellae
  publication-title: J Bone Joint Surg Br
  doi: 10.1302/0301-620X.43B4.752
  contributor:
    fullname: Outerbridge
– start-page: 43
  year: 1985
  ident: 10.1016/j.arthro.2012.05.883_bib15
  article-title: Rating systems in the evaluation of knee ligament injuries
  publication-title: Clin Orthop Relat Res
  contributor:
    fullname: Tegner
– volume: 88
  start-page: 2502
  year: 2006
  ident: 10.1016/j.arthro.2012.05.883_bib3
  article-title: Autologous chondrocyte implantation
  publication-title: J Bone Joint Surg Am
  doi: 10.2106/00004623-200611000-00025
  contributor:
    fullname: Jones
– volume: 39
  start-page: 2566
  year: 2011
  ident: 10.1016/j.arthro.2012.05.883_bib29
  article-title: Five-year outcome of characterized chondrocyte implantation versus microfracture for symptomatic cartilage defects of the knee: Early treatment matters
  publication-title: Am J Sports Med
  doi: 10.1177/0363546511422220
  contributor:
    fullname: Vanlauwe
– volume: 37
  start-page: 2053
  year: 2009
  ident: 10.1016/j.arthro.2012.05.883_bib31
  article-title: Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: An evidence-based systematic analysis
  publication-title: Am J Sports Med
  doi: 10.1177/0363546508328414
  contributor:
    fullname: Mithoefer
– volume: 87
  start-page: 640
  year: 2005
  ident: 10.1016/j.arthro.2012.05.883_bib24
  article-title: Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: A prospective, randomised study
  publication-title: J Bone Joint Surg Br
  doi: 10.1302/0301-620X.87B5.15905
  contributor:
    fullname: Bartlett
– volume: 331
  start-page: 889
  year: 1994
  ident: 10.1016/j.arthro.2012.05.883_bib2
  article-title: Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199410063311401
  contributor:
    fullname: Brittberg
– volume: 38
  start-page: 943
  year: 2010
  ident: 10.1016/j.arthro.2012.05.883_bib27
  article-title: Autologous chondrocyte implantation in cartilage lesions of the knee: Long-term evaluation with magnetic resonance imaging and delayed gadolinium-enhanced magnetic resonance imaging technique
  publication-title: Am J Sports Med
  doi: 10.1177/0363546509358266
  contributor:
    fullname: Vasiliadis
– start-page: 95
  year: 2002
  ident: 10.1016/j.arthro.2012.05.883_bib16
  article-title: Development and validation of health-related quality of life measures for the knee
  publication-title: Clin Orthop Relat Res
  doi: 10.1097/00003086-200209000-00009
  contributor:
    fullname: Irrgang
– volume: 11
  start-page: R33
  year: 2009
  ident: 10.1016/j.arthro.2012.05.883_bib4
  article-title: Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: Four-year clinical results
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar2638
  contributor:
    fullname: Kreuz
SSID ssj0003383
Score 2.346193
Snippet Purpose The purpose of this study was to evaluate the overall long-term improvement of autologous chondrocyte implantation (ACI) treatment in terms of patient...
The purpose of this study was to evaluate the overall long-term improvement of autologous chondrocyte implantation (ACI) treatment in terms of patient...
PURPOSEThe purpose of this study was to evaluate the overall long-term improvement of autologous chondrocyte implantation (ACI) treatment in terms of patient...
SourceID proquest
crossref
pubmed
pascalfrancis
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 1851
SubjectTerms Adolescent
Adult
Age Factors
Arthroscopy
Biological and medical sciences
Cartilage, Articular - injuries
Cartilage, Articular - surgery
Cell Transplantation
Chondrocytes - transplantation
Contraindications
Endoscopy
Female
Follow-Up Studies
Humans
Investigative techniques, diagnostic techniques (general aspects)
Knee Joint - surgery
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Orthopedic surgery
Orthopedics
Osteochondrosis - surgery
Patient Satisfaction
Retrospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Time Factors
Tissue and Organ Harvesting - methods
Treatment Outcome
Young Adult
Title First-Generation Autologous Chondrocyte Implantation in Patients With Cartilage Defects of the Knee: 7 to 14 Years' Clinical and Magnetic Resonance Imaging Follow-up Evaluation
URI https://www.clinicalkey.es/playcontent/1-s2.0-S074980631201448X
https://dx.doi.org/10.1016/j.arthro.2012.05.883
https://www.ncbi.nlm.nih.gov/pubmed/23036160
https://search.proquest.com/docview/1221857986
Volume 28
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LbtQwFLVKu0FCCMRreFRGQmJRpYod5zHspkNLeXXTFsrKihOnTUUzVScDgq_io_gQ7rUdJ22peGxGoyiZOHNO7j1Ozr0m5NlYV1HOAIEoKcJApBruuSpOAgXaWBUsLHWB9c7vd5LtffHmID5YWvo5cC0tWrVefP9tXcn_oArbAFeskv0HZP2Pwgb4DvjCJyAMn3-F8VYN2i2wnaMNjpOFWY4Wba3Toxn2Iii-tdq0AM4b5yusG-zLX5vKto-1LUFq68_o3XmpvbkD9ejbRpvK9RQFKhNrn-CuMKaLaVdOaV0ahw1WQpo3AY2pQHh9Ytc-2gKSzb4Gi9O1Td9UfKiGJ2e4SgMWxvReZKBkWds3ISr3ZUS7xRG-0t9IIAKZ8P3Fp5MdSOxHM9tccop2wibvw-rhiVsEetc6AiBp46UPn3UwfsE34otwznlEQQSNIdG6OKldHOdJEHGXYFyg59mQ0HwQtkG0sIEEYJltEH8pvdgnHcfrufl70BjIse9rlkV9OvUmx10cGI6LcZy2ZgfXyAq2axTLZOXVxrsPE68YIt8u1l5IV-JpfIiXz3WVhLpxms8B-8quyHL1lMlIp71b5Kab89CJJfBtsqSbO-THRfLSnrx0QF46JC-tG9qRlyJ5qScvdeSls4oCeSmS9wVNaTujTFBD3ee0Iy4F4tKOuNQTlzriUk9c2hP3Ltnf2tybbgdu-ZCgECJtg5yXWay4iqOwVIWKeJEUMHsWSqkiEQUTcZTElY4gNimY1AAD46zkWVqGPK3GkPrukeVm1ugHhMIcQjA11qWOKjGOyzzWuuKKZVVYJZCmRyToEJGntkuM7OyTx9IiKBFBGcYSEByRtINNdhXQkLP13AWXuWRyDjvLSxwaHuk0stW-Ejj6h3OunuOHHyhPUtgrFiPytCOMhByDLw7zRgPoknGOLePGWTIi9y2T-qNRA7MkfPjfA3tErvf3-mOy3J4t9BNQ-q1adTfKL-PdApc
link.rule.ids 314,780,784,27924,27925
linkProvider Elsevier
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=First-Generation+Autologous+Chondrocyte+Implantation+in+Patients+With+Cartilage+Defects+of+the+Knee%3A+7+to+14+Years%27+Clinical+and+Magnetic+Resonance+Imaging+Follow-up+Evaluation&rft.jtitle=Arthroscopy&rft.au=Moradi%2C+Babak&rft.au=Sch%C3%B6nit%2C+Eva&rft.au=Nierhoff%2C+Corinna&rft.au=Hagmann%2C+S%C3%A9bastien&rft.date=2012-12-01&rft.pub=Elsevier+Inc&rft.issn=0749-8063&rft.eissn=1526-3231&rft.volume=28&rft.issue=12&rft.spage=1851&rft.epage=1861&rft_id=info:doi/10.1016%2Fj.arthro.2012.05.883&rft.externalDocID=S074980631201448X
thumbnail_m http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F07498063%2FS0749806311X00270%2Fcov150h.gif