First-Generation Autologous Chondrocyte Implantation in Patients With Cartilage Defects of the Knee: 7 to 14 Years' Clinical and Magnetic Resonance Imaging Follow-up Evaluation

• Published in: Arthroscopy Vol. 28; no. 12; pp. 1851 - 1861
• Main Authors: Moradi, Babak, M.D, Schönit, Eva, M.D, Nierhoff, Corinna, M.D, Hagmann, Sébastien, M.D, Oberle, Doris, M.D., Ph.D, Gotterbarm, Tobias, M.D, Schmitt, Holger, M.D., Ph.D, Zeifang, Felix, M.D., Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2012; Elsevier
• Subjects: Adolescent; Adult; Age Factors; Arthroscopy; Biological and medical sciences; Cartilage, Articular - injuries; Cartilage, Articular - surgery; Cell Transplantation; Chondrocytes - transplantation; Contraindications; Endoscopy; Female; Follow-Up Studies; Humans; Investigative techniques, diagnostic techniques (general aspects); Knee Joint - surgery; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Orthopedic surgery; Orthopedics; Osteochondrosis - surgery; Patient Satisfaction; Retrospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Time Factors; Tissue and Organ Harvesting - methods; Treatment Outcome; Young Adult; Knee; Human; Cartilage; Autograft; Chondrocyte implantation; Arthroscopy; Orthopedic surgery; Treatment; Medical imagery; Endoscopy; Nuclear magnetic resonance imaging
• ISSN: 0749-8063; 1526-3231
• DOI: 10.1016/j.arthro.2012.05.883

Purpose The purpose of this study was to evaluate the overall long-term improvement of autologous chondrocyte implantation (ACI) treatment in terms of patient satisfaction, clinical assessment, and magnetic resonance imaging (MRI) evaluation. Furthermore, we aimed to assess the impact of independent variables on clinical outcomes and patient satisfaction. Methods We evaluated 23 patients (mean age, 30.5 ± 8.2 years) with full-thickness chondral lesions of the distal femur who underwent first-generation ACI with periosteum between 1997 and 2004. The Lysholm score, Tegner activity score, subjective International Knee Documentation Committee score, numeric rating scale score, and Short Form 36 score were used for clinical assessment preoperatively, at 1 year postoperatively, and at 7 to 14 years (mean, 9.9 years) after surgery. MRI was performed to evaluate the cartilage preoperatively and at final follow-up, by use of the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score. Results ACI resulted in a substantial improvement in all clinical outcome parameters, even as much as 14 years after implantation, although a small deterioration was noticed between intermediate and final evaluations in some outcome parameters. Of the patients, 73.1% stated that they would undergo the operation again. Younger patients with a shorter duration of preoperative symptoms and smaller defect sizes benefited most. MRI findings confirmed complete defect filling in 52.3% of the patients at final follow-up. Conclusions Our long-term results confirm that first-generation ACI is an effective treatment for large full-thickness chondral and osteochondral lesions of the knee joint. Younger patients with a shorter duration of preoperative symptoms and smaller defect size benefited most in our study. Level of Evidence Level IV, therapeutic case series.