Metastatic gallbladder cancer presenting as numb chin syndrome: A case report and literature review

• Published in: Biomedical reports Vol. 20; no. 4; p. 61
• Main Authors: Murahashi, Makoto, Ntege, Edward Hosea, Ide, Kentaro, Maruyama, Nobuyuki, Shirakawa, Jumpei, Koyama, Hiroki, Kawano, Toshihiro, Goto, Takahiro, Shimizu, Yusuke, Nishihara, Kazuhide, Nakamura, Hiroyuki
• Format: Journal Article
• Language: English
• Published: England Spandidos Publications 01.04.2024; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Adenocarcinoma; Biopsy; Cancer; Case Report; Case reports; Cellular biology; Chemotherapy; Chin; Computed tomography; CT imaging; Denosumab; Diagnosis; Females; Gallbladder; Gallbladder cancer; Glucose; Hematology; Hospitals; Jaw; Literature reviews; Magnetic resonance imaging; Malignancy; Medical prognosis; Metastases; Metastasis; PET imaging; Positron emission; Positron emission tomography; Prostheses; Radiotherapy; Signs and symptoms; Skin cancer; Tomography; Tumors; Type 2 diabetes; Japan; case report; numb chin syndrome; oral metastases; mandibular osteomyelitis; metastatic gallbladder cancer; pathological fracture
• ISSN: 2049-9434; 2049-9442
• DOI: 10.3892/br.2024.1749

Gallbladder cancer (GBC) is an uncommon malignancy that is highly aggressive in the advanced stages. However, it rarely metastasizes to the mandible. Numb chin syndrome (NCS) is a rare neurological manifestation associated with various underlying causes, including occult primary cancers and distant metastases. It is often considered to be a significant indicator of malignancy, and thorough investigation is essential in the presence of unclear etiology. The current study reported on the case of a 69-year-old Japanese woman who presented with numbness and mild pain in the lower lip and chin area for three months. No other systemic symptoms were observed. Immunocytochemical examination revealed the presence of an adenocarcinoma and TNM staging as per the Union for International Cancer Control and the American Joint Committee on Cancer guidelines confirmed stage IVb GBC. Comprehensive full-body positron emission tomography-computed tomography examination using F-fluoro-2-deoxy-D-glucose revealed additional bone and soft-tissue metastases. Palliative chemotherapy and radiation treatment were initiated based on the advanced stage of disease at the time of diagnosis. However, the patient succumbed to multiple organ failure six months later. The simultaneous occurrence of GBC, mandibular metastasis and NCS is rare and associated with poor prognosis. Despite the widespread nature of the disease, it can often manifest as non-specific oral symptoms without any systemic indications. The current study emphasizes the critical importance of timely confirmatory testing for accurate diagnosis and initiation of appropriate management for such complex conditions.