Dupuytren’s Disease susceptibility gene, EPDR1, is involved in myofibroblast contractility

Highlights • All three EPDR1 transcripts are detected in affected Dupuytren’s tissue. • Dupuytren’s tissue contracts more in the FPCL paradigm. • Knockdown of EPDR1 moderately attenuates late stage of contraction rate in FPCL.

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Bibliographic Details
Published inJournal of dermatological science Vol. 83; no. 2; pp. 131 - 137
Main Authors Staats, Kim A, Wu, Timothy, Gan, Bing S, O’Gorman, David B, Ophoff, Roel A
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ireland Ltd 01.08.2016
Subjects
Cells, Cultured
Collagen - metabolism
Dermatology
Dupuytren Contracture - genetics
Dupuytren Contracture - metabolism
Dupuytren’s contracture
Ependymin
Fascia - metabolism
FPCL
Genetic Predisposition to Disease
Genetics
Genome-Wide Association Study
GWAS
Humans
Muscle Contraction - genetics
Myofibroblasts - metabolism
Myofibroblasts - physiology
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Polymorphism, Single Nucleotide
Primary Cell Culture
RNA Interference
Dupuytren's Contracture
FPCL
genetics
GWAS
ependymin
Ependymin
Genetics
Dupuytren’s contracture
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Summary:Highlights • All three EPDR1 transcripts are detected in affected Dupuytren’s tissue. • Dupuytren’s tissue contracts more in the FPCL paradigm. • Knockdown of EPDR1 moderately attenuates late stage of contraction rate in FPCL.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2016.04.015