Effects of interleukin-2 on bioelectric activity of rat atrial myocardium under normal conditions and during gradual stretching

• Published in: Immunology letters Vol. 167; no. 1; pp. 23 - 28
• Main Authors: Aksyonov, A, Mitrokhin, V.M, Mladenov, M.I
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2015
• Subjects: Action potential; Action Potentials - drug effects; Allergy and Immunology; Animals; Atrial Function - drug effects; Atrial Function - physiology; Atrium; Electrophysiological Phenomena - drug effects; Heart; Interleukin 2; Interleukin-2 - pharmacology; Male; Muscle Contraction; Myocardium - metabolism; Myocytes, Cardiac - drug effects; Rats; Stretch; Tachycardia; Heart; RAP; APD25; resting potential; Action potential; cAMP; MGCs; Interleukin 2; interleukine 2; Atrium; SIDs; APs; action potentials; Stretch; IL-2; SERCA; action potential durations to 50% of repolarization (APD50) and action potential durations to 90% of repolarization; APA; action potential durations to 25% of repolarization; action potential amplitude; cyclic adenosine monophosphate; APD90; stretch induced depolarizations; right atrial preparation; mechanically gated channels; RP; sarcoplasmic reticulum calcium adenosine triphosphate-ase
• ISSN: 0165-2478; 1879-0542
• DOI: 10.1016/j.imlet.2015.06.009

Highlights • IL-2 induce frequent rhythm patterns followed by smooth transient fragments of paroxysmal tachyarrhythmia. • In the presence of IL-2, stretching of the tissue led to appearance of abnormal bio-electrical activity, predominantly in the lengthening of APD90. • There is a link between the IL-2 and stretch induced mechanisms.