Successful Treatment of Steroid-Resistant Minimal Change Disease with Mycophenolate Mofetil

Mycophenolate mofetil has been reported to be effective in the treatment of steroid-responsive minimal change disease. We report a case of steroid- and cyclosporin-resistant minimal change disease with severe nephrotic syndrome that responded to mycophenolate mofetil with complete remission. The pat...

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Bibliographic Details
Published inAmerican journal of nephrology Vol. 22; no. 5-6; pp. 569 - 572
Main Authors Mogyorósi, András, Lippman, H. Robert, Feldman, George M.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland Karger 01.09.2002
S. Karger AG
Subjects
Biological and medical sciences
Case Report
Drug Resistance
Humans
Immunomodulators
Immunosuppressive Agents - therapeutic use
Male
Medical sciences
Middle Aged
Mycophenolic Acid - analogs & derivatives
Mycophenolic Acid - therapeutic use
Nephrosis, Lipoid - drug therapy
Pharmacology. Drug treatments
Steroids - therapeutic use
Mycophenolate
Minimal change disease
Treatment
Human
Glomerulonephritis
Kidney disease
Mofetil
Steroid
Treatment resistance
Urinary system disease
Mycophenolic acid
Treatment efficiency
Male
Case study
Pathology
Chemotherapy
Histopathology
Adult
Diagnosis
Immunosuppressive agent
Minimal change nephrotic syndrome
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Summary:Mycophenolate mofetil has been reported to be effective in the treatment of steroid-responsive minimal change disease. We report a case of steroid- and cyclosporin-resistant minimal change disease with severe nephrotic syndrome that responded to mycophenolate mofetil with complete remission. The patient remains in complete remission 1 year after the discontinuation of mycophenolate mofetil. The presented case argues for the need of a prospective controlled study with the goal of evaluating the efficacy of mycophenolate mofetil in the therapy of steroid-resistant minimal change disease.
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ISSN:0250-8095
1421-9670
DOI:10.1159/000065276