Outcome Predictors and Safety of Home Dobutamine Intravenous Infusion in End Stage Heart Failure Patients

• Published in: Journal of clinical medicine Vol. 10; no. 12; p. 2571
• Main Authors: Jobbé-Duval, Antoine, Bochaton, Thomas, Baudry, Guillaume, Bonnefoy-Cudraz, Eric, Hugon-Vallet, Elisabeth, Pozzi, Matteo, Obadia, Jean-Francois, Tomasevic, Danka, Amaz, Camille, Mewton, Nathan, Sebbag, Laurent
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 10.06.2021; MDPI
• Subjects: Clinical medicine; Clinical outcomes; Critical care; Electronic health records; end-stage heart failure; Heart failure; Heart surgery; Heart transplants; home dobutamine; Hospitalization; Hospitals; Life Sciences; Medical records; Mortality; Patients; safety; SANOFI-GENZYME; mortality; end-stage heart failure; BOEHRINGER-INGELHEIM; safety; home dobutamine
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm10122571

Patients in end-stage heart failure can experiment cardiogenic shock and may not be weanable from dobutamine. The fate of these patients is a challenge for doctors, patients, family, and the institution. Dobutamine use at home can be a solution. The aim of the present study was to assess the outcome, biological predictors, and safety of dobutamine use at home in dobutamine-dependent patients. All consecutive dobutamine-dependent patients discharged with continuous home intravenous dobutamine, from a single tertiary center between February 2014 and November 2019, were retrospectively analyzed. A total of 19 patients (age 65 ± 10 years) were followed for one year. At one-year, the survival rate was 32%, (6/19). Five (26%) patients had an adverse event related to the intravenous catheter. In a multivariate logistic regression analysis, the combination of a glomerular filtration rate >60 mL/min and a brain natriuretic peptide level <1000 ng/L, were highly predictive of one-year survival (HR = 10.87, IC95% (5.78–36.44), p < 0.001). Management of dobutamine-unweanable patients after cardiogenic shock may involve dobutamine at home to permit a home return. This strategy allows a significant survival and few readmissions, and, if eligible, access to surgical strategies, such as heart transplantation. Simple biological markers at discharge can identify severe patients to refer to palliative care and good responders.