Hypocholesterolemic action of dietary grifolin on rats fed with a high-cholesterol diet

The hypocholesterolemic action of grifolin was investigated in terms of its structure-activity relationship with rats fed on a high-cholesterol diet. The results show that the structure of farnesylorcinol was required for the hypocholesterolemic action, and that the effect of grifolin might be elici...

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Published inBioscience, biotechnology, and biochemistry Vol. 58; no. 1; pp. 211 - 212
Main Authors Sugiyama, K. (Shizuoka Univ. (Japan). Faculty of Agriculture), Tanaka, A, Kawagishi, H, Ojima, F, Sakamoto, H, Ishiguro, Y
Format Journal Article
LanguageEnglish
Published Tokyo Taylor & Francis 01.01.1994
Japan Society for Bioscience Biotechnology and Agrochemistry
Subjects
Biological and medical sciences
CHOLESTEROL
COLESTEROL
DIETA
ENDOTOXINAS
ENDOTOXINE
General pharmacology
HIPOPLASIA
HYPOPLASIE
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
RAT
RATA
REGIME ALIMENTAIRE
REGULACION FISIOLOGICA
REGULATION PHYSIOLOGIQUE
Rat
Rodentia
Metabolic diseases
Lipids
Hyperlipoproteinemia
Biological activity
Cholesterol
Fungi
Vertebrata
Chemotherapy
Experimental disease
Mammalia
Hypercholesterolemia
Treatment
Animal
Plant origin
Thallophyta
Antilipemic agent
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Summary:The hypocholesterolemic action of grifolin was investigated in terms of its structure-activity relationship with rats fed on a high-cholesterol diet. The results show that the structure of farnesylorcinol was required for the hypocholesterolemic action, and that the effect of grifolin might be elicited, at least in part, through the augmented excretion of cholesterol into the feces
Bibliography:L51
9407305
L02
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.58.211