High-resolution axillary ultrasound is a poor prognostic test for determining pathologic lymph node status in patients undergoing neoadjuvant chemotherapy for locally advanced breast cancer

The purpose of this study was to evaluate the efficacy of high-resolution axillary ultrasound in detecting axillary lymph node metastases after neoadjuvant chemotherapy in patients with locally advanced breast cancer. Fifty-three patients with stage II or III breast cancer undergoing neoadjuvant che...

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Published inThe American journal of surgery Vol. 188; no. 4; pp. 386 - 389
Main Authors Klauber-DeMore, Nancy, Kuzmiak, Cherie, Rager, Erika L., Ogunrinde, Oyinkansola B., Ollila, David W., Calvo, Benjamin F., Kim, Hong Jin, Meyer, Anthony, Dees, Claire, Graham, Mark, Collichio, Frances A., Sartor, Carolyn I., Metzger, Richard, Carey, Lisa A.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.10.2004
Elsevier
Elsevier Limited
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Summary:The purpose of this study was to evaluate the efficacy of high-resolution axillary ultrasound in detecting axillary lymph node metastases after neoadjuvant chemotherapy in patients with locally advanced breast cancer. Fifty-three patients with stage II or III breast cancer undergoing neoadjuvant chemotherapy who had a physical examination, high-resolution axillary ultrasound, and axillary lymph node dissection from January 1999 to September 2003 were included in this study. The positive predictive value of the postchemotherapy ultrasound for predicting pathologic nodal involvement was 83%, but the negative predictive value was only 52%. Postchemotherapy physical examination was also poor at predicting pathologic nodal involvement with a positive predictive value of 93% and a negative predictive value of only 58%. A negative post–neoadjuvant chemotherapy high-resolution axillary ultrasound or physical examination does not predict pathologic node status, and this test has limited value in this setting.
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ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2004.06.022