Pancreatic follicular lymphoma: a report of two cases and literature review

Primary pancreatic lymphomas are extremely rare, accounting for 0.1–0.5% of malignant lymphomas and about 0.2% of primary pancreatic tumors. They occur most commonly in the pancreatic head of elderly males, with diffuse large B-cell lymphoma being the most common subtype. Primary pancreatic follicul...

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Published inClinical journal of gastroenterology Vol. 14; no. 6; pp. 1756 - 1765
Main Authors Okamoto, Takeshi, Sasaki, Takashi, Nishimura, Noriko, Takamatsu, Manabu, Mori, Chinatsu, Mie, Takafumi, Furukawa, Takaaki, Yamada, Yuto, Takeda, Tsuyoshi, Kasuga, Akiyoshi, Matsuyama, Masato, Ozaka, Masato, Maruyama, Dai, Sasahira, Naoki
Format Journal Article
LanguageEnglish
Published Singapore Springer Singapore 01.12.2021
Subjects
Abdominal Surgery
Case Report
Colorectal Surgery
Gastroenterology
Hepatology
Medicine
Medicine & Public Health
Surgical Oncology
Endoscopic ultrasound-guided fine-needle aspiration
Malignant lymphoma
Monoclonal antibody
Pancreas
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Summary:Primary pancreatic lymphomas are extremely rare, accounting for 0.1–0.5% of malignant lymphomas and about 0.2% of primary pancreatic tumors. They occur most commonly in the pancreatic head of elderly males, with diffuse large B-cell lymphoma being the most common subtype. Primary pancreatic follicular lymphoma is the most commonly reported primary pancreatic indolent lymphoma, accounting for 9–14% of primary pancreatic lymphomas. We report two cases of primary pancreatic follicular lymphoma treated with obinutuzumab, a second-generation humanized anti-CD20 monoclonal antibody, and bendamustine. One was diagnosed by endoscopic ultrasound-guided fine-needle aspiration, while the other required laparoscopic lymph node sampling to reach a diagnosis. Both achieved complete response with induction therapy and opted for maintenance therapy with obinutuzumab. We also conducted a literature review of primary pancreatic follicular lymphoma cases reported over the last 30 years.
Bibliography:ObjectType-Case Study-3
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ISSN:1865-7257
1865-7265
DOI:10.1007/s12328-021-01507-2