Micro-ribonucleic acid modulation with oxidative stress and inflammation in patients with type 2 diabetes mellitus - a review article

In parallel with the rapid growth of obesity, there is also an increase in the prevalence of type 2 diabetes mellitus (T2D) worldwide. Due to its complications, cardiovascular diseases are the leading cause of death in those patients. In the last two decades, special attention has been given to oxid...

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Published inArchives of medical science Vol. 18; no. 4; pp. 870 - 880
Main Authors Klisic, Aleksandra, Radoman Vujacic, Irena, Munjas, Jelena, Ninic, Ana, Kotur-Stevuljevic, Jelena
Format Journal Article
LanguageEnglish
Published Poland Termedia Publishing House 2022
Subjects
diabetes
inflammation
micro-ribonucleic acids
oxidative stress
State of the Art Paper
inflammation
diabetes
micro-ribonucleic acids
oxidative stress
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Summary:In parallel with the rapid growth of obesity, there is also an increase in the prevalence of type 2 diabetes mellitus (T2D) worldwide. Due to its complications, cardiovascular diseases are the leading cause of death in those patients. In the last two decades, special attention has been given to oxidative stress and inflammation, as the underlying mechanisms related to T2D occurrence and progression. Moreover, micro-ribonucleic acids (miRNAs) as new genetic biomarkers take an important place in the investigation of different metabolic pathways of insulin signaling. In this review article, we discuss microRNA modulation with oxidative stress and inflammation in patients with T2D. Better insight into the novel potential therapeutic targets for treatment of diabetes and its complications is of utmost importance for public health.
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ISSN:1734-1922
1896-9151
DOI:10.5114/aoms/146796