Circulating fibrocytes correlate with the asthma control test score

• Published in: Allergologia et immunopathologia Vol. 44; no. 3; p. 191
• Main Authors: Kobayashi, H, Naito, M, Masuya, M, Maruyama, M, Urata, K, Takahashi, Y, Tomaru, A, Fujiwara, K, Ohnishi, M, Takagi, T, Kobayashi, T, D'Alessandro-Gabazza, C, Urawa, M, Gabazza, E C, Taguchi, O, Takei, Y
• Format: Journal Article
• Language: English
• Published: Spain 01.05.2016
• Subjects: Adrenergic beta-2 Receptor Agonists - administration & dosage; Adrenergic beta-2 Receptor Agonists - therapeutic use; Adult; Aged; Asthma - blood; Asthma - drug therapy; Biomarkers - blood; Collagen Type I - metabolism; Female; Flow Cytometry; Humans; Inflammation - blood; Japan; Leukocyte Common Antigens - metabolism; Male; Mesenchymal Stromal Cells - immunology; Mesenchymal Stromal Cells - metabolism; Middle Aged; Respiratory Function Tests; Surveys and Questionnaires; Treatment Outcome; Bronchial asthma; Asthma control test; Short-acting Beta2 agonist; Fibrocytes
• ISSN: 1578-1267
• DOI: 10.1016/j.aller.2015.09.007

Bronchial asthma is characterised by airway inflammation and remodelling with a decline of lung function. Fibrocytes are bone marrow-derived mesenchymal progenitor cells that play important roles in the pathogenesis of airway remodelling. Several clinical parameters are currently being used in routine clinical practice to assess outcome of therapy in asthma including frequency of rescue with short-acting β2-agonist and the asthma control test. In this study, we hypothesised that asthma control test is associated with circulating levels of fibrocytes in bronchial asthma. There were 20 patients with asthma and seven healthy controls. The number of CD45(+)Collagen I(+) circulating fibrocytes was assessed in the peripheral blood by flow cytometry. The number of circulating fibrocytes was significantly increased in asthma patients with moderate and severe disease compared to controls, and it was inversely correlated with % forced expiratory volume in one second and % forced vital capacity (%FVC). The frequency of inhalation of short-acting β2 agonist and the asthma control test score was significantly and inversely correlated with the number of circulating fibrocytes. The results of this study showed that the number of circulating fibrocytes is inversely correlated with clinical asthma control parameters, further supporting the relevance of measuring circulating fibrocytes as a marker of clinical control in bronchial asthma.