Anticipating a MERS-like coronavirus as a potential pandemic threat

[...]since merbecoviruses occur worldwide, increased attention and investments are needed for human, camel, and bat research to enable the rapid development of diagnostics, vaccines, and antivirals if a merbecovirus-mediated human disease is identified. [...]improved understanding of why some corona...

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Published inThe Lancet (British edition) Vol. 403; no. 10438; pp. 1729 - 1731
Main Authors Zumla, Alimuddin, Peiris, Malik, Memish, Ziad A, Perlman, Stanley
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 04.05.2024
Elsevier Limited
Subjects
Antiviral agents
Antiviral drugs
Camelids
Coronaviridae
Coronavirus Infections - epidemiology
Coronavirus Infections - prevention & control
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 vaccines
Disease transmission
Global health
Health planning
Humans
Investments
Middle East respiratory syndrome
Middle East Respiratory Syndrome Coronavirus
Pandemics
Public health
R&D
Research & development
Respiratory diseases
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Viral diseases
Viruses
Zoonoses
Middle East
Saudi Arabia
Arabian Peninsula
Asia
United States > US
Africa
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Summary:[...]since merbecoviruses occur worldwide, increased attention and investments are needed for human, camel, and bat research to enable the rapid development of diagnostics, vaccines, and antivirals if a merbecovirus-mediated human disease is identified. [...]improved understanding of why some coronaviruses robustly infect the human upper airway, facilitating transmission in pre-symptomatic and early symptomatic disease, whereas others (eg, SARS-CoV) that also use the ACE2 receptor do not will be important to identify merbecoviruses with pandemic potential. Predicting the future evolutionary trajectory of MERS-CoV, MERS-like coronaviruses, and other coronaviruses remains important for public health planning and will require substantial financial investments. Since Saudi Arabia and Arabian Gulf countries have been grappling with Middle East respiratory syndrome for the past decade, they are in a strong position to take leadership of the portfolio of defined research and development priorities.
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ISSN:0140-6736
1474-547X
1474-547X
DOI:10.1016/S0140-6736(24)00641-X