Gastroretentive delivery systems: a mini review

Various attempts have been made to develop gastroretentive delivery systems. For example, floating, swelling, mucoadhesive, and high-density systems have been developed to increase gastric retention time of the dosage forms. It is known that differences in gastric physiology, such as, gastric pH, an...

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Bibliographic Details
Published inDrug development and industrial pharmacy Vol. 30; no. 10; p. 1019
Main Authors Talukder, R, Fassihi, R
Format Journal Article
LanguageEnglish
Published England 2004
Subjects
Drug Delivery Systems - methods
Gastric Emptying - drug effects
Gastric Emptying - physiology
Gastrointestinal Transit - drug effects
Gastrointestinal Transit - physiology
Humans
Technology, Pharmaceutical - methods
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Summary:Various attempts have been made to develop gastroretentive delivery systems. For example, floating, swelling, mucoadhesive, and high-density systems have been developed to increase gastric retention time of the dosage forms. It is known that differences in gastric physiology, such as, gastric pH, and motility exhibit both intra- as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behavior. Nevertheless, some floating devices have shown promising results. In this paper, the gastric physiology and the reported intragastric delivery systems have briefly been presented.
ISSN:0363-9045
DOI:10.1081/DDC-200040239