Synthesis and applications of sulfopropyl ether γ-cyclodextrin polymer as chiral selector in capillary electrophoresis

• Published in: Analytical and bioanalytical chemistry Vol. 408; no. 13; pp. 3639 - 3649
• Main Authors: Bao, James J., Jia, Feifei, Li, Youxin, Liang, Qinggang, Wang, Yan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2016
• Subjects: Analytical Chemistry; Biochemistry; Capillarity; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Cyclodextrins; Electrophoresis; Ethers; Food Science; Infrared spectroscopy; Laboratory Medicine; Monitoring/Environmental Analysis; Research Paper; Separation; Synthesis; Recyclable chiral selectors; Great reproducibility; Capillary electrophoresis; Low cost; Enantiomer separation; Sulfopropyl ether γ-cyclodextrin polymer
• ISSN: 1618-2642; 1618-2650
• DOI: 10.1007/s00216-016-9452-9

A novel sulfopropyl ether γ-cyclodextrin polymer (SPE-γ-CDP) through polycondensating sulfated cyclodextrins (SCDs) was synthesized. This synthesis approach also has the potential of preparing other derived cyclodextrins (CDs) polymers. The polymerized SCDs took on both the properties of SCDs and certain characteristics of polymers, such as chiral selectivity and high viscosity. Synthesis parameters, including reactions sequence, sulfation, and polycondensation conditions were investigated systematically. The product was characterized by elemental analysis, infrared spectroscopy (IR), and indirect UV detections prior to use as background electrolytes additive. The separation conditions, including the concentration of SPE-γ-CDP, the concentration and pH of running buffer, separation voltage, as well as the additional organic solution were optimized during chiral separation of neutral, acidic, and basic enantiomers in capillary electrophoresis (CE). SPE-γ-CDP was proven to be an effective chiral resolving agent in CE with the advantages of simple synthesis process, low cost, similar ratio of charge-to-mass, low current, great reproducibility, and reusability. Graphical Abstract Synthesis and applications of sulfopropyl ether γ-cyclodextrin polymer