Effect of degradation of PLGA and PLGA/β-TCP scaffolds on the growth of osteoblasts

• Published in: Chinese science bulletin Vol. 56; no. 10; pp. 982 - 986
• Main Authors: Yang, YanFang, Tang, GongWen, Zhao, YunHui, Zhang, Yang, Li, XiuLan, Yuan, XiaoYan
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer-Verlag 01.04.2011; SP Science China Press
• Subjects: Biocompatibility; cell viability; Chemistry/Food Science; Earth Sciences; Engineering; Humanities and Social Sciences; Life Sciences; multidisciplinary; osteoblasts; Physics; PLGA; Science; Science (multidisciplinary); TCP; 多孔支架; 成骨细胞; 生物相容性; 细胞生长; 细胞相容性; 退化; degradation; PLGA; osteoblast; scaffold; β-TCP
• ISSN: 1001-6538; 1861-9541
• DOI: 10.1007/s11434-010-4132-1

Osteoblasts were cultured on porous scaffolds of poly（L-lactide-co-glycolide） （PLGA） and PLGA/β-tficalcium phosphate （β-TCP） to evaluate their cytocompatibility. The proliferation of the cells on both scaffolds was examined before and after in vitro degra- dation for 4, 8 and 12 weeks under static （shaking water bath） and dynamic （cyclic loading） conditions. Results indicate that po- rous PLGA and PLGA/β-TCP scaffolds have good biocompatibility and can be used as effective templates for guiding the growth of osteoblasts. The degradation of the scaffolds affects the proliferation of osteoblasts and the cell viability decreased with the degradation time.