Inhibition of platelet activation and aggregation by furostanol saponins isolated from the bulbs of Allium macrostemon Bunge

Three new furostanol saponins (FSs) were recently isolated from the dried bulbs of Allium macrostemon and were shown to have antiplatelet effects. This study investigated the inhibitory capabilities of these compounds on adenosine diphosphate (ADP)-induced human platelet activation. FS-1, when compa...

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Bibliographic Details
Published inThe American journal of the medical sciences Vol. 344; no. 4; p. 261
Main Authors Ou, Wen-Chao, Chen, Hai-Feng, Zhong, Yun, Liu, Ben-Rong, Liu, Shi-Ming, Chen, Ke-Ji
Format Journal Article
LanguageEnglish
Published United States 01.10.2012
Subjects
Adenosine Diphosphate - metabolism
Adolescent
Adult
Allium - chemistry
Blood Platelets - drug effects
Blood Platelets - physiology
Female
Flow Cytometry
Humans
Male
Middle Aged
Plant Roots
Platelet Activation - drug effects
Platelet Aggregation - drug effects
Saponins - isolation & purification
Saponins - pharmacology
Signal Transduction
Sterols - isolation & purification
Sterols - pharmacology
Young Adult
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Summary:Three new furostanol saponins (FSs) were recently isolated from the dried bulbs of Allium macrostemon and were shown to have antiplatelet effects. This study investigated the inhibitory capabilities of these compounds on adenosine diphosphate (ADP)-induced human platelet activation. FS-1, when compared with the other 2, had a potent inhibitory effect on ADP-induced platelet aggregation and on the expression of P-selectin and integrin β-3. FS-1 also inhibited Ca mobilization and significantly decreased phosphorylated AKT expression in ADP-activated platelets. The suppression by FS-1 of ADP-induced platelet activation and aggregation shown in this study indicate its potential for therapeutic applications.
ISSN:1538-2990
DOI:10.1097/MAJ.0b013e31823ea9f0