Prevalence and distribution of MRI abnormalities in patients with psychogenic nonepileptic events

Abstract Introduction Both structural and functional abnormalities have been reported in patients with psychogenic nonepileptic events (PNEEs), although no truly consistent abnormalities have been found. Methods We retrospectively identified patients discharged from our EMU with video-EEG diagnoses...

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Published inEpilepsy & behavior Vol. 59; pp. 73 - 76
Main Authors Bolen, Robert D, Koontz, Elizabeth H, Pritchard, Paul B
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2016
Subjects
Adult
Brain - diagnostic imaging
Brain - physiopathology
Comorbidity
Electroencephalography - methods
Epilepsy - diagnostic imaging
Epilepsy - epidemiology
Female
Humans
Magnetic Resonance Imaging - methods
Male
Mental Disorders - diagnostic imaging
Mental Disorders - epidemiology
Mental Disorders - physiopathology
Middle Aged
Neuroimaging
Neurology
Pathophysiology
Patient Discharge
Prevalence
Psychogenic nonepileptic events
Retrospective Studies
Seizures - diagnostic imaging
Seizures - epidemiology
Seizures - physiopathology
Video-EEG
Neuroimaging
Pathophysiology
Video-EEG
Psychogenic nonepileptic events
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Summary:Abstract Introduction Both structural and functional abnormalities have been reported in patients with psychogenic nonepileptic events (PNEEs), although no truly consistent abnormalities have been found. Methods We retrospectively identified patients discharged from our EMU with video-EEG diagnoses of epileptic seizures, PNEEs, epileptic seizures plus PNEEs, interictal epileptiform abnormalities only, and nondiagnostic admissions. We then collected brain MRI results for analysis. Results We found significant brain MRI abnormalities in 33.8% of patients with PNEEs, clearly higher than the rate of brain MRI abnormalities in the healthy population. In addition, we found statistically significant differences in the locations of brain MRI abnormalities in patients with epileptic seizures (more frequently temporal) versus PNEEs (more frequently multifocal). Conclusion This multifocal nature of abnormalities in patients with psychogenic nonepileptic events may help to explain the underlying pathophysiology as it relates to psychiatric disorders which are so frequently comorbid with PNEEs.
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ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2016.02.036