Differences in neonatal exposure to estradiol or testosterone on ovarian function and hormonal levels

Highlights • Androgen induces more pronounced reproductive changes that mimic PCOS pathogenesis. • Neonatal androgen or estrogen exposure leads to different phenotypes in adult rats. • Androgen treatment in early life increases LH and testosterone levels in adult rats. • Estrogen treatment in early...

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Published inGeneral and comparative endocrinology Vol. 212; pp. 28 - 33
Main Authors Marcondes, Rodrigo R, Carvalho, Kátia C, Duarte, Daniele C, Garcia, Natália, Amaral, Vinícius C, Simões, Manuel J, Lo Turco, Edson G, Soares, José M, Baracat, Edmund C, Maciel, Gustavo A.R
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2015
Subjects
17-Alpha-hydroxylase
Androgens - pharmacology
Animal models
Animals
Animals, Newborn - metabolism
Endocrinology & Metabolism
Estradiol - pharmacology
Estrogens - pharmacology
Female
Follicle Stimulating Hormone - blood
LH receptor
Luteinizing Hormone - blood
Ovarian Follicle - cytology
Ovarian Follicle - physiology
Polycystic ovary syndrome
Polycystic Ovary Syndrome - drug therapy
Polycystic Ovary Syndrome - metabolism
Polycystic Ovary Syndrome - pathology
Rats
Rats, Wistar
Steroid
Testosterone - pharmacology
Steroid
17-Alpha-hydroxylase
Polycystic ovary syndrome
LH receptor
Animal models
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Summary:Highlights • Androgen induces more pronounced reproductive changes that mimic PCOS pathogenesis. • Neonatal androgen or estrogen exposure leads to different phenotypes in adult rats. • Androgen treatment in early life increases LH and testosterone levels in adult rats. • Estrogen treatment in early life alters folliculogenesis during rat adulthood.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2015.01.006