Environmental and bioanalytical applications of hollow fiber membrane liquid-phase microextraction: A review

• Published in: Analytica chimica acta Vol. 624; no. 2; pp. 253 - 268
• Main Authors: Lee, Jingyi, Lee, Hian Kee, Rasmussen, Knut E., Pedersen-Bjergaard, Stig
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 29.08.2008; Elsevier
• Subjects: Analytic Sample Preparation Methods - methods; Analytical chemistry; Applied sciences; Beverages; Bioanalytical applications; Chemistry; Chromatographic methods and physical methods associated with chromatography; Environmental applications; Environmental Pollutants - chemistry; Environmental Pollutants - isolation & purification; Exact sciences and technology; Food; Gas chromatographic methods; Global environmental pollution; Hollow fiber membranes; Humans; Liquid-phase microextraction; Membranes, Artificial; Other chromatographic methods; Pharmaceutical Preparations - blood; Pharmaceutical Preparations - chemistry; Pharmaceutical Preparations - isolation & purification; Pharmaceutical Preparations - urine; Pollution; Sample preparation; Hollow fiber membranes; Liquid-phase microextraction; Bioanalytical applications; Environmental applications; Sample preparation; Biochemical analysis; Capillary electrophoresis; Microanalysis; HPLC chromatography; Review; Liquid phase; Chemical enrichment; Gas chromatography; Organic solvent; Hollow fiber; Microextraction; Environment
• ISSN: 0003-2670; 1873-4324
• DOI: 10.1016/j.aca.2008.06.050

In hollow fiber membrane liquid-phase microextraction (LPME), target analytes are extracted from aqueous samples and into a supported liquid membrane (SLM) sustained in the pores in the wall of a small porous hollow fiber, and further into an acceptor phase present inside the lumen of the hollow fiber. The acceptor phase can be organic, providing a two-phase extraction system compatible with capillary gas chromatography, or the acceptor phase can be aqueous resulting in a three-phase system compatible with high-performance liquid chromatography or capillary electrophoresis. Due to high enrichment, efficient sample clean-up, and the low consumption of organic solvent, substantial interest has been devoted to LPME in recent years. This paper reviews important applications of LPME with special focus on bioanalytical and environmental chemistry, and also covers a new possible direction for LPME namely electromembrane extraction, where analytes are extracted through the SLM and into the acceptor phase by the application of electrical potentials.