Association of interleukin-10 polymorphisms with risk factors of Alzheimer’s disease and other dementias (SADEM study)

• Published in: Immunology letters Vol. 177; pp. 47 - 52
• Main Authors: Vargas-Alarcón, Gilberto, Ph.D, Juárez-Cedillo, Enrique, MsC, Martínez-Rodríguez, Nancy, MsC, Fragoso, José Manuel, Ph.D, García-Hernández, Normand, Ph.D, Juárez-Cedillo, Teresa, Ph.D
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2016
• Subjects: Aged; Aged, 80 and over; Allergy and Immunology; Alzheimer Disease - genetics; Alzheimer Disease - immunology; Alzheimer's disease; Dementia; Dementia - genetics; Dementia - immunology; Female; Gene Frequency; Genetic association; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Interleukin; Interleukin-10 - genetics; Male; Mexico; Polymorphism, Single Nucleotide; Polymorphisms; Risk Factors; Haplotypes; AD; mixed dementia; Alzheimer disease; single nucleotide polymorphism; vascular dementia; Interleukin; Polymorphisms; interleukin-10; IL-10; proto-oncogene; AD/VaD; MAF; SNP; VaD; Genetic association; Alzheimer's disease; Dementia
• ISSN: 0165-2478; 1879-0542
• DOI: 10.1016/j.imlet.2016.07.011

Highlights • This research hypothesizes possible mechanisms involved in the pathological process of dementia, as the role that IL-10 in this disease. • Limiting the inflammatory response could slow the development and progression of the disease. • These results clarify an association not only between Interleukin-10 and AD but also with other dementias in the Mexican population.