Planar Polarity and Tissue Morphogenesis

Planar polarity is a global, tissue-level phenomenon that coordinates cell behavior in a two-dimensional plane. The Frizzled/planar cell polarity (PCP) and anterior-posterior (AP) patterning systems for planar polarity operate in a variety of cell types and provide direction to cells with different...

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Bibliographic Details
Published inCell Vol. 129; no. 6; pp. 1051 - 1063
Main Author Zallen, Jennifer A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.06.2007
Subjects
Animals
Body Patterning
Cell Communication
Cell Polarity
Drosophila - genetics
Drosophila - metabolism
Epithelium - metabolism
Frizzled Receptors - metabolism
Gene Expression Regulation, Developmental
Models, Biological
Morphogenesis
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Summary:Planar polarity is a global, tissue-level phenomenon that coordinates cell behavior in a two-dimensional plane. The Frizzled/planar cell polarity (PCP) and anterior-posterior (AP) patterning systems for planar polarity operate in a variety of cell types and provide direction to cells with different morphologies and behaviors. These two systems involve different sets of proteins but both use directional cues provided locally by communication between neighboring cells. This review describes our current understanding of the mechanisms that transmit directional signals from cell to cell and compares the strategies for generating global systems of spatial information in stationary and dynamic cell populations.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2007.05.050