FXR： a metabolic regulator and cell protector

Farnesoid X receptor （FXR） is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key roles in bile acid, cholesterol, lipid, and glucose metabolism. Therefore, FXR is a potential drug target for a number of metabolic disorders,...

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Published in	Cell research Vol. 18; no. 11; pp. 1087 - 1095
Main Authors	Wang, Yan-Dong, Chen, Wei-Dong, Moore, David D, Huang, Wendong
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 01.11.2008 Nature Publishing Group
Subjects	Bile Acids and Salts - genetics Bile Acids and Salts - metabolism Biomedical and Life Sciences Cell Biology Cholesterol Cholesterol - genetics Cholesterol - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism FXR Glucose - metabolism Life Sciences Liver - cytology Liver - physiology Liver Diseases - genetics Liver Diseases - metabolism Liver Regeneration - genetics Metabolic disorders Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism review Transcription Factors - genetics Transcription Factors - metabolism 接受器新陈代谢 FXR metabolism hepatocarcinogenesis bile acid liver regeneration
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Abstract	Farnesoid X receptor （FXR） is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key roles in bile acid, cholesterol, lipid, and glucose metabolism. Therefore, FXR is a potential drug target for a number of metabolic disorders, especially those related to the metabolic syndrome. More recently, our group and others have extended the functions of FXR to more than metabolic regulation, which include anti-bacterial growth in intestine, liver regeneration, and hepatocarcinogenesis. These new findings suggest that FXR has much broader roles than previously thought, and also higi.light FXR as a drug target for multiple diseases. This review summarizes the basic information of FXR but focuses on its new functions.
AbstractList	Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key roles in bile acid, cholesterol, lipid, and glucose metabolism. Therefore, FXR is a potential drug target for a number of metabolic disorders, especially those related to the metabolic syndrome. More recently, our group and others have extended the functions of FXR to more than metabolic regulation, which include anti-bacterial growth in intestine, liver regeneration, and hepatocarcinogenesis. These new findings suggest that FXR has much broader roles than previously thought, and also highlight FXR as a drug target for multiple diseases. This review summarizes the basic information of FXR but focuses on its new functions. Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key roles in bile acid, cholesterol, lipid, and glucose metabolism. Therefore, FXR is a potential drug target for a number of metabolic disorders, especially those related to the metabolic syndrome. More recently, our group and others have extended the functions of FXR to more than metabolic regulation, which include anti-bacterial growth in intestine, liver regeneration, and hepatocarcinogenesis. These new findings suggest that FXR has much broader roles than previously thought, and also highlight FXR as a drug target for multiple diseases. This review summarizes the basic information of FXR but focuses on its new functions.Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key roles in bile acid, cholesterol, lipid, and glucose metabolism. Therefore, FXR is a potential drug target for a number of metabolic disorders, especially those related to the metabolic syndrome. More recently, our group and others have extended the functions of FXR to more than metabolic regulation, which include anti-bacterial growth in intestine, liver regeneration, and hepatocarcinogenesis. These new findings suggest that FXR has much broader roles than previously thought, and also highlight FXR as a drug target for multiple diseases. This review summarizes the basic information of FXR but focuses on its new functions. Farnesoid X receptor （FXR） is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key roles in bile acid, cholesterol, lipid, and glucose metabolism. Therefore, FXR is a potential drug target for a number of metabolic disorders, especially those related to the metabolic syndrome. More recently, our group and others have extended the functions of FXR to more than metabolic regulation, which include anti-bacterial growth in intestine, liver regeneration, and hepatocarcinogenesis. These new findings suggest that FXR has much broader roles than previously thought, and also higi.light FXR as a drug target for multiple diseases. This review summarizes the basic information of FXR but focuses on its new functions.
Author	Yan-Dong Wang Wei-Dong Chen David D Moore Wendong Huang
AuthorAffiliation	Department of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center, 1500 E.Duarte Road, Duarte, CA 91010, USA Department of Molecular and Cellular Biology, Baylor College of Medicine, One BaylorPlaza, Houston, TX 77030, USA
Author_xml	– sequence: 1 givenname: Yan-Dong surname: Wang fullname: Wang, Yan-Dong organization: Department of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center – sequence: 2 givenname: Wei-Dong surname: Chen fullname: Chen, Wei-Dong organization: Department of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center – sequence: 3 givenname: David D surname: Moore fullname: Moore, David D organization: Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza – sequence: 4 givenname: Wendong surname: Huang fullname: Huang, Wendong email: whuang@coh.org organization: Department of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18825165$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1074/jbc.M209505200 10.1007/BF02072092 10.1021/jm0002127 10.1089/1044549041562267 10.1126/science.1121435 10.1210/me.2007-0089 10.1194/jlr.M400102-JLR200 10.1159/000129252 10.1152/ajpregu.00781.2006 10.1016/0092-8674(95)90199-X 10.1021/jm025529g 10.1124/jpet.105.085597 10.1101/gad.1138104 10.1016/S0168-8278(00)80412-2 10.1016/j.febslet.2004.04.026 10.1053/jhep.2003.50175 10.1016/j.febslet.2006.07.082 10.1016/S1097-2765(00)00050-2 10.1074/jbc.M306309200 10.1073/pnas.0506982103 10.1074/jbc.274.42.29749 10.1136/gut.24.8.767 10.1073/pnas.0603499103 10.1074/jbc.M207510200 10.1016/j.febslet.2007.11.015 10.1074/jbc.M011610200 10.1053/j.gastro.2004.08.001 10.1073/pnas.0400046101 10.1016/S0140-6736(97)08002-1 10.1074/jbc.M007998200 10.1124/jpet.105.097758 10.1172/JCI0214505 10.1016/S0960-894X(03)00281-6 10.1074/jbc.M411473200 10.1101/gad.1083503 10.1194/jlr.M400292-JLR200 10.1210/en.2004-0965 10.1158/0008-5472.CAN-06-2399 10.1046/j.1440-1746.2001.02430.x 10.1158/0008-5472.CAN-05-2937 10.1172/JCI21025 10.1016/S0168-8278(05)80609-9 10.1074/jbc.M302128200 10.1152/ajpgi.00491.2002 10.1016/j.cell.2005.04.014 10.1016/S0378-1119(02)00557-7 10.1016/S0966-842X(00)88906-4 10.1074/jbc.M209863200 10.1016/S0092-8674(00)00062-3 10.1074/jbc.M302505200 10.1002/hep.20969 10.1126/science.284.5418.1362 10.1016/S1097-2765(00)80348-2 10.1074/jbc.M510258200 10.1016/S1097-2765(03)00112-6 10.1042/cs0780055 10.1038/nature04870 10.1126/science.294.5548.1866 10.1074/jbc.M109326200 10.1016/j.ccr.2006.12.016 10.1161/01.ATV.0000235697.35431.05 10.1007/s10549-007-9535-6 10.1074/jbc.M107557200 10.1161/01.ATV.0000178994.21828.a7 10.1074/jbc.275.14.10638 10.1016/0092-8674(95)90530-8 10.1038/sj.ejcn.1601396 10.1158/0008-5472.CAN-06-1078 10.1016/j.cmet.2005.09.001 10.1053/jhep.2001.21902 10.1093/carcin/bgl249 10.1016/j.tips.2007.03.002 10.1172/JCI25604 10.1016/j.tibs.2006.08.002 10.1152/ajplegacy.1959.197.4.880 10.1210/en.2005-1485 10.1128/MCB.23.3.864-872.2003 10.1126/science.284.5418.1365 10.1016/S1097-2765(00)00051-4 10.1016/S0022-2275(20)30180-2 10.1016/S0925-4439(97)00063-X
ContentType	Journal Article
Copyright	Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2008 Copyright Nature Publishing Group Nov 2008
Copyright_xml	– notice: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2008 – notice: Copyright Nature Publishing Group Nov 2008
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References	Hubbert, Zhang, Lee, Edwards (CR47) 2007; 21 Ma, Saha, Chan, Moore (CR57) 2006; 116 Fiorucci, Antonelli, Rizzo (CR80) 2004; 127 Claudel, Staels, Kuipers (CR29) 2005; 25 Deugnier, Turlin (CR68) 2001; 16 Shibata, Morizane, Uchida (CR35) 1998; 351 Garcia-Marin, Regueiro, Perez-Antona, Villanueva, Perez-Barriocanal (CR65) 1990; 78 Cariou, van Harmelen, Duran-Sandoval (CR58) 2006; 281 Costarelli, Sanders (CR84) 2002; 56 Ding, Andersson, Soltesz, Willen, Bengmark (CR60) 1993; 25 Propst, Propst, Dietze, Judmaier, Braunsteiner, Vogel (CR69) 1994; 21 Wilkinson, Portmann, Williams (CR75) 1983; 24 Swales, Korbonits, Carpenter, Walsh, Warner, Bishop-Bailey (CR83) 2006; 66 Edwards, Kast, Anisfeld (CR50) 2002; 43 Otte, Kranz, Kober (CR10) 2003; 23 Parks, Blanchard, Bledsoe (CR18) 1999; 284 Maloney, Parks, Haffner (CR24) 2000; 43 Sakurai, Maeda, Chang, Karin (CR73) 2006; 103 Glass (CR8) 1994; 15 Zhang, Wang, Vales (CR82) 2006; 26 Song, Echchgadda, Baek (CR32) 2001; 276 Zhang, Castellani, Sinal, Gonzalez, Edwards (CR53) 2004; 18 Wang, Chen, Hollister, Sowers, Forman (CR16) 1999; 3 Cai, Xiong, Wray, Ballatori, Boyer (CR9) 2007; 293 Li, Pircher, Schulman, Westin (CR33) 2005; 280 Urizar, Dowhan, Moore (CR39) 2000; 275 Grober, Zaghini, Fujii (CR36) 1999; 274 Bianchi (CR74) 1993; 152 Huber, Murphy, Miao (CR11) 2002; 290 Fausto, Campbell, Riehle (CR62) 2006; 43 Zhang, Kast-Woelbern, Edwards (CR5) 2003; 278 Nishimaki-Mogami, Une, Fujino (CR22) 2004; 45 Journe, Laurent, Chaboteaux (CR61) 2008; 107 Claudel, Sturm, Duez (CR43) 2002; 109 Lu, Makishima, Repa (CR44) 2000; 6 Ananthanarayanan, Balasubramanian, Makishima, Mangelsdorf, Suchy (CR34) 2001; 276 Wang, Lai, Moy, Bhat, Hartman, Evans (CR20) 2006; 147 Stayrook, Bramlett, Savkur (CR55) 2005; 146 Goodwin, Jones, Price (CR37) 2000; 6 Maeda, Kamata, Luo, Leffert, Karin (CR72) 2005; 121 Modica, Moschetta (CR28) 2006; 580 Karin (CR70) 2006; 441 Kok, Hulzebos, Wolters (CR49) 2003; 278 Zhao, Yu, Lew, Huang, Wright, Cui (CR21) 2004; 23 Pircher, Kitto, Petrowski (CR38) 2003; 278 Fausto (CR6) 2000; 32 Zhang, Edwards (CR12) 2008; 582 Yang, Huang, Yi, Yen, Moore, Huang (CR14) 2007; 67 Cariou, Staels (CR30) 2007; 28 Fiorucci, Rizzo, Antonelli (CR81) 2005; 315 Forman, Goode, Chen (CR2) 1995; 81 Mi, Devarakonda, Harp (CR26) 2003; 11 Huang, Ma, Zhang (CR13) 2006; 312 Sinal, Tohkin, Miyata, Ward, Lambert, Gonzalez (CR48) 2000; 102 Anisfeld, Kast-Woelbern, Lee, Zhang, Lee, Edwards (CR51) 2005; 46 Kim, Morimura, Shah, Yang, Ward, Gonzalez (CR15) 2007; 28 Higuchi, Gores (CR76) 2003; 284 Mauad, van Nieuwkerk, Dingemans (CR79) 1994; 145 Wang, Chen, Huang (CR3) 2008; 23 Barone, Maiorano, Ladisa (CR77) 2003; 37 Ueno, Moriyama, Uchida, Arakawa (CR63) 2001; 33 Costantino, Macchiarulo, Entrena-Guadix, Camaioni, Pellicciari (CR25) 2003; 13 Sirvent, Claudel, Martin (CR52) 2004; 566 Holt, Luo, Billin (CR46) 2003; 17 Laffitte, Kast, Nguyen, Zavacki, Moore, Edwards (CR40) 2000; 275 Watanabe, Houten, Wang (CR54) 2004; 113 Anisfeld, Kast-Woelbern, Meyer (CR41) 2003; 278 Makishima, Okamoto, Repa (CR17) 1999; 284 Wang, Krupczak-Hollis, Tan, Dennewitz, Adami, Costa (CR67) 2002; 277 Luedde, Beraza, Kotsikoris (CR71) 2007; 11 Leong, Pessotti, Brauer (CR64) 1959; 197 Zhang, Lee, Barrera (CR56) 2006; 103 Inagaki, Choi, Moschetta (CR45) 2005; 2 CR66 Mangelsdorf, Thummel, Beato (CR7) 1995; 83 Pellicciari, Fiorucci, Camaioni (CR27) 2002; 45 Lee, Lee, Hubbert, Edwards, Zhang (CR31) 2006; 31 Kast, Goodwin, Tarr (CR42) 2002; 277 Berg (CR59) 1995; 3 Katzenellenbogen, Pappo, Barash (CR78) 2006; 66 Bishop-Bailey, Walsh, Warner (CR4) 2004; 101 Deng, Yang, Yang, Yan (CR19) 2006; 317 Chawla, Repa, Evans, Mangelsdorf (CR1) 2001; 294 Dussault, Beard, Lin (CR23) 2003; 278 T Inagaki (BFcr2008289_CR45) 2005; 2 Y Zhang (BFcr2008289_CR12) 2008; 582 R Deng (BFcr2008289_CR19) 2006; 317 AM Anisfeld (BFcr2008289_CR41) 2003; 278 S Wang (BFcr2008289_CR20) 2006; 147 CJ Sinal (BFcr2008289_CR48) 2000; 102 S Fiorucci (BFcr2008289_CR81) 2005; 315 PA Edwards (BFcr2008289_CR50) 2002; 43 BFcr2008289_CR66 L Bianchi (BFcr2008289_CR74) 1993; 152 S Fiorucci (BFcr2008289_CR80) 2004; 127 JJ Garcia-Marin (BFcr2008289_CR65) 1990; 78 I Dussault (BFcr2008289_CR23) 2003; 278 M Watanabe (BFcr2008289_CR54) 2004; 113 Y Zhang (BFcr2008289_CR53) 2004; 18 M Karin (BFcr2008289_CR70) 2006; 441 T Claudel (BFcr2008289_CR43) 2002; 109 F Journe (BFcr2008289_CR61) 2008; 107 Y Deugnier (BFcr2008289_CR68) 2001; 16 F Yang (BFcr2008289_CR14) 2007; 67 T Luedde (BFcr2008289_CR71) 2007; 11 AM Anisfeld (BFcr2008289_CR51) 2005; 46 M Shibata (BFcr2008289_CR35) 1998; 351 M Makishima (BFcr2008289_CR17) 1999; 284 PC Pircher (BFcr2008289_CR38) 2003; 278 T Propst (BFcr2008289_CR69) 1994; 21 CK Glass (BFcr2008289_CR8) 1994; 15 TT Lu (BFcr2008289_CR44) 2000; 6 SY Cai (BFcr2008289_CR9) 2007; 293 Y Zhang (BFcr2008289_CR5) 2003; 278 D Bishop-Bailey (BFcr2008289_CR4) 2004; 101 T Sakurai (BFcr2008289_CR73) 2006; 103 LZ Mi (BFcr2008289_CR26) 2003; 11 S Modica (BFcr2008289_CR28) 2006; 580 W Huang (BFcr2008289_CR13) 2006; 312 A Sirvent (BFcr2008289_CR52) 2004; 566 KR Stayrook (BFcr2008289_CR55) 2005; 146 FY Lee (BFcr2008289_CR31) 2006; 31 RM Huber (BFcr2008289_CR11) 2002; 290 B Cariou (BFcr2008289_CR30) 2007; 28 J Grober (BFcr2008289_CR36) 1999; 274 ML Hubbert (BFcr2008289_CR47) 2007; 21 R Pellicciari (BFcr2008289_CR27) 2002; 45 PR Maloney (BFcr2008289_CR24) 2000; 43 S Maeda (BFcr2008289_CR72) 2005; 121 B Cariou (BFcr2008289_CR58) 2006; 281 BA Laffitte (BFcr2008289_CR40) 2000; 275 RD Berg (BFcr2008289_CR59) 1995; 3 DJ Mangelsdorf (BFcr2008289_CR7) 1995; 83 T Kok (BFcr2008289_CR49) 2003; 278 K Ma (BFcr2008289_CR57) 2006; 116 N Fausto (BFcr2008289_CR62) 2006; 43 A Chawla (BFcr2008289_CR1) 2001; 294 N Fausto (BFcr2008289_CR6) 2000; 32 DJ Parks (BFcr2008289_CR18) 1999; 284 T Nishimaki-Mogami (BFcr2008289_CR22) 2004; 45 GF Leong (BFcr2008289_CR64) 1959; 197 KE Swales (BFcr2008289_CR83) 2006; 66 Y Ueno (BFcr2008289_CR63) 2001; 33 M Katzenellenbogen (BFcr2008289_CR78) 2006; 66 X Wang (BFcr2008289_CR67) 2002; 277 M Barone (BFcr2008289_CR77) 2003; 37 J Li (BFcr2008289_CR33) 2005; 280 TH Mauad (BFcr2008289_CR79) 1994; 145 G Costantino (BFcr2008289_CR25) 2003; 13 T Claudel (BFcr2008289_CR29) 2005; 25 M Ananthanarayanan (BFcr2008289_CR34) 2001; 276 H Higuchi (BFcr2008289_CR76) 2003; 284 JW Ding (BFcr2008289_CR60) 1993; 25 Y Zhang (BFcr2008289_CR56) 2006; 103 Y Zhang (BFcr2008289_CR82) 2006; 26 K Otte (BFcr2008289_CR10) 2003; 23 NL Urizar (BFcr2008289_CR39) 2000; 275 H Wang (BFcr2008289_CR16) 1999; 3 V Costarelli (BFcr2008289_CR84) 2002; 56 HR Kast (BFcr2008289_CR42) 2002; 277 YD Wang (BFcr2008289_CR3) 2008; 23 CS Song (BFcr2008289_CR32) 2001; 276 B Goodwin (BFcr2008289_CR37) 2000; 6 A Zhao (BFcr2008289_CR21) 2004; 23 JA Holt (BFcr2008289_CR46) 2003; 17 BM Forman (BFcr2008289_CR2) 1995; 81 I Kim (BFcr2008289_CR15) 2007; 28 ML Wilkinson (BFcr2008289_CR75) 1983; 24
References_xml	– volume: 278 start-page: 104 year: 2003 end-page: 110 ident: CR5 article-title: Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation publication-title: J Biol Chem doi: 10.1074/jbc.M209505200 – volume: 152 start-page: S63 year: 1993 end-page: S70 ident: CR74 article-title: Glycogen storage disease I and hepatocellular tumours publication-title: Eur J Pediatr doi: 10.1007/BF02072092 – volume: 43 start-page: 2971 year: 2000 end-page: 2974 ident: CR24 article-title: Identification of a chemical tool for the orphan nuclear receptor FXR publication-title: J Med Chem doi: 10.1021/jm0002127 – volume: 23 start-page: 519 year: 2004 end-page: 526 ident: CR21 article-title: Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets publication-title: DNA Cell Biol doi: 10.1089/1044549041562267 – volume: 145 start-page: 1237 year: 1994 end-page: 1245 ident: CR79 article-title: Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis publication-title: Am J Pathol – volume: 312 start-page: 233 year: 2006 end-page: 236 ident: CR13 article-title: Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration publication-title: Science doi: 10.1126/science.1121435 – volume: 21 start-page: 1359 year: 2007 end-page: 1369 ident: CR47 article-title: Regulation of hepatic Insig-2 by the farnesoid X receptor publication-title: Mol Endocrinol doi: 10.1210/me.2007-0089 – volume: 45 start-page: 1538 year: 2004 end-page: 1545 ident: CR22 article-title: Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor publication-title: J Lipid Res doi: 10.1194/jlr.M400102-JLR200 – volume: 25 start-page: 11 year: 1993 end-page: 19 ident: CR60 article-title: The role of bile and bile acids in bacterial translocation in obstructive jaundice in rats publication-title: Eur Surg Res doi: 10.1159/000129252 – volume: 293 start-page: R1400 year: 2007 end-page: R1409 ident: CR9 article-title: The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.00781.2006 – volume: 83 start-page: 835 year: 1995 end-page: 839 ident: CR7 article-title: The nuclear receptor superfamily: the second decade publication-title: Cell doi: 10.1016/0092-8674(95)90199-X – volume: 45 start-page: 3569 year: 2002 end-page: 3572 ident: CR27 article-title: 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity publication-title: J Med Chem doi: 10.1021/jm025529g – volume: 315 start-page: 58 year: 2005 end-page: 68 ident: CR81 article-title: Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.105.085597 – volume: 18 start-page: 157 year: 2004 end-page: 169 ident: CR53 article-title: Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR publication-title: Genes Dev doi: 10.1101/gad.1138104 – volume: 32 start-page: 19 year: 2000 end-page: 31 ident: CR6 article-title: Liver regeneration publication-title: J Hepatol doi: 10.1016/S0168-8278(00)80412-2 – volume: 566 start-page: 173 year: 2004 end-page: 177 ident: CR52 article-title: The farnesoid X receptor induces very low density lipoprotein receptor gene expression publication-title: FEBS Lett doi: 10.1016/j.febslet.2004.04.026 – volume: 37 start-page: 880 year: 2003 end-page: 886 ident: CR77 article-title: Influence of ursodeoxycholate-enriched diet on liver tumor growth in HBV transgenic mice publication-title: Hepatology doi: 10.1053/jhep.2003.50175 – volume: 580 start-page: 5492 year: 2006 end-page: 5499 ident: CR28 article-title: Nuclear bile acid receptor FXR as pharmacological target: are we there yet? publication-title: FEBS Lett doi: 10.1016/j.febslet.2006.07.082 – volume: 6 start-page: 507 year: 2000 end-page: 515 ident: CR44 article-title: Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors publication-title: Mol Cell doi: 10.1016/S1097-2765(00)00050-2 – volume: 278 start-page: 41930 year: 2003 end-page: 41937 ident: CR49 article-title: Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein publication-title: J Biol Chem doi: 10.1074/jbc.M306309200 – volume: 103 start-page: 1006 year: 2006 end-page: 1011 ident: CR56 article-title: Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0506982103 – volume: 274 start-page: 29749 year: 1999 end-page: 29754 ident: CR36 article-title: Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer publication-title: J Biol Chem doi: 10.1074/jbc.274.42.29749 – volume: 24 start-page: 767 year: 1983 end-page: 771 ident: CR75 article-title: Wilson's disease and hepatocellular carcinoma: possible protective role of copper publication-title: Gut doi: 10.1136/gut.24.8.767 – volume: 103 start-page: 10544 year: 2006 end-page: 10551 ident: CR73 article-title: Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0603499103 – volume: 277 start-page: 44310 year: 2002 end-page: 44316 ident: CR67 article-title: Increased hepatic Forkhead Box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27Kip1 protein levels and increased Cdc25B expression publication-title: J Biol Chem doi: 10.1074/jbc.M207510200 – volume: 582 start-page: 10 year: 2008 end-page: 18 ident: CR12 article-title: FXR signaling in metabolic disease publication-title: FEBS Lett doi: 10.1016/j.febslet.2007.11.015 – volume: 276 start-page: 28857 year: 2001 end-page: 28865 ident: CR34 article-title: Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor publication-title: J Biol Chem doi: 10.1074/jbc.M011610200 – volume: 127 start-page: 1497 year: 2004 end-page: 1512 ident: CR80 article-title: The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis publication-title: Gastroenterology doi: 10.1053/j.gastro.2004.08.001 – volume: 101 start-page: 3668 year: 2004 end-page: 3673 ident: CR4 article-title: Expression and activation of the farnesoid X receptor in the vasculature publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0400046101 – volume: 351 start-page: 1773 year: 1998 end-page: 1777 ident: CR35 article-title: Irregular regeneration of hepatocytes and risk of hepatocellular carcinoma in chronic hepatitis and cirrhosis with hepatitis-C-virus infection publication-title: Lancet doi: 10.1016/S0140-6736(97)08002-1 – volume: 275 start-page: 39313 year: 2000 end-page: 39317 ident: CR39 article-title: The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression publication-title: J Biol Chem doi: 10.1074/jbc.M007998200 – volume: 317 start-page: 317 year: 2006 end-page: 325 ident: CR19 article-title: Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.105.097758 – volume: 109 start-page: 961 year: 2002 end-page: 971 ident: CR43 article-title: Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element publication-title: J Clin Invest doi: 10.1172/JCI0214505 – volume: 13 start-page: 1865 year: 2003 end-page: 1868 ident: CR25 article-title: Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR) publication-title: Bioorg Med Chem Lett doi: 10.1016/S0960-894X(03)00281-6 – volume: 280 start-page: 7427 year: 2005 end-page: 7434 ident: CR33 article-title: Regulation of complement C3 expression by the bile acid receptor FXR publication-title: J Biol Chem doi: 10.1074/jbc.M411473200 – volume: 17 start-page: 1581 year: 2003 end-page: 1591 ident: CR46 article-title: Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis publication-title: Genes Dev doi: 10.1101/gad.1083503 – volume: 15 start-page: 391 year: 1994 end-page: 407 ident: CR8 article-title: Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers publication-title: Endocr Rev – volume: 46 start-page: 458 year: 2005 end-page: 468 ident: CR51 article-title: Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling publication-title: J Lipid Res doi: 10.1194/jlr.M400292-JLR200 – volume: 146 start-page: 984 year: 2005 end-page: 991 ident: CR55 article-title: Regulation of carbohydrate metabolism by the farnesoid X receptor publication-title: Endocrinology doi: 10.1210/en.2004-0965 – volume: 66 start-page: 10120 year: 2006 end-page: 10126 ident: CR83 article-title: The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-2399 – volume: 16 start-page: 491 year: 2001 end-page: 494 ident: CR68 article-title: Iron and hepatocellular carcinoma publication-title: J Gastroenterol Hepatol doi: 10.1046/j.1440-1746.2001.02430.x – volume: 66 start-page: 4001 year: 2006 end-page: 4010 ident: CR78 article-title: Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the Mdr2-knockout mice publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-2937 – volume: 113 start-page: 1408 year: 2004 end-page: 1418 ident: CR54 article-title: Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c publication-title: J Clin Invest doi: 10.1172/JCI21025 – volume: 21 start-page: 1006 year: 1994 end-page: 1011 ident: CR69 article-title: Prevalence of hepatocellular carcinoma in alpha-1-antitrypsin deficiency publication-title: J Hepatol doi: 10.1016/S0168-8278(05)80609-9 – volume: 278 start-page: 27703 year: 2003 end-page: 27711 ident: CR38 article-title: Farnesoid X receptor regulates bile acid-amino acid conjugation publication-title: J Biol Chem doi: 10.1074/jbc.M302128200 – ident: CR66 – volume: 284 start-page: G734 year: 2003 end-page: G738 ident: CR76 article-title: Bile acid regulation of hepatic physiology: IV. Bile acids and death receptors publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00491.2002 – volume: 23 start-page: 621 year: 2008 end-page: 627 ident: CR3 article-title: FXR, a target for different diseases publication-title: Histol Histopathol – volume: 121 start-page: 977 year: 2005 end-page: 990 ident: CR72 article-title: IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis publication-title: Cell doi: 10.1016/j.cell.2005.04.014 – volume: 290 start-page: 35 year: 2002 end-page: 43 ident: CR11 article-title: Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters publication-title: Gene doi: 10.1016/S0378-1119(02)00557-7 – volume: 3 start-page: 149 year: 1995 end-page: 154 ident: CR59 article-title: Bacterial translocation from the gastrointestinal tract publication-title: Trends Microbiol doi: 10.1016/S0966-842X(00)88906-4 – volume: 278 start-page: 7027 year: 2003 end-page: 7033 ident: CR23 article-title: Identification of gene-selective modulators of the bile acid receptor FXR publication-title: J Biol Chem doi: 10.1074/jbc.M209863200 – volume: 102 start-page: 731 year: 2000 end-page: 744 ident: CR48 article-title: Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis publication-title: Cell doi: 10.1016/S0092-8674(00)00062-3 – volume: 278 start-page: 20420 year: 2003 end-page: 20428 ident: CR41 article-title: Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor publication-title: J Biol Chem doi: 10.1074/jbc.M302505200 – volume: 43 start-page: S45 year: 2006 end-page: S53 ident: CR62 article-title: Liver regeneration publication-title: Hepatology doi: 10.1002/hep.20969 – volume: 284 start-page: 1362 year: 1999 end-page: 1365 ident: CR17 article-title: Identification of a nuclear receptor for bile acids publication-title: Science doi: 10.1126/science.284.5418.1362 – volume: 3 start-page: 543 year: 1999 end-page: 553 ident: CR16 article-title: Endogenous bile acids are ligands for the nuclear receptor FXR/BAR publication-title: Mol Cell doi: 10.1016/S1097-2765(00)80348-2 – volume: 281 start-page: 11039 year: 2006 end-page: 11049 ident: CR58 article-title: The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice publication-title: J Biol Chem doi: 10.1074/jbc.M510258200 – volume: 11 start-page: 1093 year: 2003 end-page: 1100 ident: CR26 article-title: Structural basis for bile acid binding and activation of the nuclear receptor FXR publication-title: Mol Cell doi: 10.1016/S1097-2765(03)00112-6 – volume: 78 start-page: 55 year: 1990 end-page: 62 ident: CR65 article-title: Pre-replicative phase-related changes in bile acid-induced choleresis in the regenerating rat liver publication-title: Clin Sci (Lond) doi: 10.1042/cs0780055 – volume: 441 start-page: 431 year: 2006 end-page: 436 ident: CR70 article-title: Nuclear factor-kappaB in cancer development and progression publication-title: Nature doi: 10.1038/nature04870 – volume: 294 start-page: 1866 year: 2001 end-page: 1870 ident: CR1 article-title: Nuclear receptors and lipid physiology: opening the X-files publication-title: Science doi: 10.1126/science.294.5548.1866 – volume: 277 start-page: 2908 year: 2002 end-page: 2915 ident: CR42 article-title: Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor publication-title: J Biol Chem doi: 10.1074/jbc.M109326200 – volume: 43 start-page: 2 year: 2002 end-page: 12 ident: CR50 article-title: BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis publication-title: J Lipid Res – volume: 11 start-page: 119 year: 2007 end-page: 132 ident: CR71 article-title: Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma publication-title: Cancer Cell doi: 10.1016/j.ccr.2006.12.016 – volume: 26 start-page: 2316 year: 2006 end-page: 2321 ident: CR82 article-title: FXR deficiency causes reduced atherosclerosis in Ldlr−/− mice publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000235697.35431.05 – volume: 107 start-page: 49 year: 2008 end-page: 61 ident: CR61 article-title: Farnesol, a mevalonate pathway intermediate, stimulates MCF-7 breast cancer cell growth through farnesoid-X-receptor-mediated estrogen receptor activation publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-007-9535-6 – volume: 276 start-page: 42549 year: 2001 end-page: 42556 ident: CR32 article-title: Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor publication-title: J Biol Chem doi: 10.1074/jbc.M107557200 – volume: 25 start-page: 2020 year: 2005 end-page: 2030 ident: CR29 article-title: The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000178994.21828.a7 – volume: 275 start-page: 10638 year: 2000 end-page: 10647 ident: CR40 article-title: Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor publication-title: J Biol Chem doi: 10.1074/jbc.275.14.10638 – volume: 81 start-page: 687 year: 1995 end-page: 693 ident: CR2 article-title: Identification of a nuclear receptor that is activated by farnesol metabolites publication-title: Cell doi: 10.1016/0092-8674(95)90530-8 – volume: 56 start-page: 925 year: 2002 end-page: 927 ident: CR84 article-title: Plasma deoxycholic acid concentration is elevated in postmenopausal women with newly diagnosed breast cancer publication-title: Eur J Clin Nutr doi: 10.1038/sj.ejcn.1601396 – volume: 67 start-page: 863 year: 2007 end-page: 867 ident: CR14 article-title: Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-1078 – volume: 2 start-page: 217 year: 2005 end-page: 225 ident: CR45 article-title: Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis publication-title: Cell Metab doi: 10.1016/j.cmet.2005.09.001 – volume: 33 start-page: 357 year: 2001 end-page: 362 ident: CR63 article-title: Irregular regeneration of hepatocytes is an important factor in the hepatocarcinogenesis of liver disease publication-title: Hepatology doi: 10.1053/jhep.2001.21902 – volume: 28 start-page: 940 year: 2007 end-page: 946 ident: CR15 article-title: Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice publication-title: Carcinogenesis doi: 10.1093/carcin/bgl249 – volume: 28 start-page: 236 year: 2007 end-page: 243 ident: CR30 article-title: FXR: a promising target for the metabolic syndrome? publication-title: Trends Pharmacol Sci doi: 10.1016/j.tips.2007.03.002 – volume: 116 start-page: 1102 year: 2006 end-page: 1109 ident: CR57 article-title: Farnesoid X receptor is essential for normal glucose homeostasis publication-title: J Clin Invest doi: 10.1172/JCI25604 – volume: 31 start-page: 572 year: 2006 end-page: 580 ident: CR31 article-title: FXR, a multipurpose nuclear receptor publication-title: Trends Biochem Sci doi: 10.1016/j.tibs.2006.08.002 – volume: 197 start-page: 880 year: 1959 end-page: 886 ident: CR64 article-title: Liver function in regenerating fat liver. CrPO4 colloid uptake and bile flow publication-title: Am J Physiol doi: 10.1152/ajplegacy.1959.197.4.880 – volume: 147 start-page: 4025 year: 2006 end-page: 4033 ident: CR20 article-title: The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone publication-title: Endocrinology doi: 10.1210/en.2005-1485 – volume: 23 start-page: 864 year: 2003 end-page: 872 ident: CR10 article-title: Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol publication-title: Mol Cell Biol doi: 10.1128/MCB.23.3.864-872.2003 – volume: 284 start-page: 1365 year: 1999 end-page: 1368 ident: CR18 article-title: Bile acids: natural ligands for an orphan nuclear receptor publication-title: Science doi: 10.1126/science.284.5418.1365 – volume: 6 start-page: 517 year: 2000 end-page: 526 ident: CR37 article-title: A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis publication-title: Mol Cell doi: 10.1016/S1097-2765(00)00051-4 – volume: 113 start-page: 1408 year: 2004 ident: BFcr2008289_CR54 publication-title: J Clin Invest doi: 10.1172/JCI21025 – volume: 312 start-page: 233 year: 2006 ident: BFcr2008289_CR13 publication-title: Science doi: 10.1126/science.1121435 – volume: 317 start-page: 317 year: 2006 ident: BFcr2008289_CR19 publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.105.097758 – volume: 45 start-page: 3569 year: 2002 ident: BFcr2008289_CR27 publication-title: J Med Chem doi: 10.1021/jm025529g – volume: 24 start-page: 767 year: 1983 ident: BFcr2008289_CR75 publication-title: Gut doi: 10.1136/gut.24.8.767 – volume: 67 start-page: 863 year: 2007 ident: BFcr2008289_CR14 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-1078 – volume: 21 start-page: 1359 year: 2007 ident: BFcr2008289_CR47 publication-title: Mol Endocrinol doi: 10.1210/me.2007-0089 – volume: 2 start-page: 217 year: 2005 ident: BFcr2008289_CR45 publication-title: Cell Metab doi: 10.1016/j.cmet.2005.09.001 – volume: 278 start-page: 7027 year: 2003 ident: BFcr2008289_CR23 publication-title: J Biol Chem doi: 10.1074/jbc.M209863200 – volume: 21 start-page: 1006 year: 1994 ident: BFcr2008289_CR69 publication-title: J Hepatol doi: 10.1016/S0168-8278(05)80609-9 – volume: 152 start-page: S63 year: 1993 ident: BFcr2008289_CR74 publication-title: Eur J Pediatr doi: 10.1007/BF02072092 – volume: 23 start-page: 519 year: 2004 ident: BFcr2008289_CR21 publication-title: DNA Cell Biol doi: 10.1089/1044549041562267 – volume: 26 start-page: 2316 year: 2006 ident: BFcr2008289_CR82 publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000235697.35431.05 – volume: 46 start-page: 458 year: 2005 ident: BFcr2008289_CR51 publication-title: J Lipid Res doi: 10.1194/jlr.M400292-JLR200 – volume: 278 start-page: 20420 year: 2003 ident: BFcr2008289_CR41 publication-title: J Biol Chem doi: 10.1074/jbc.M302505200 – volume: 66 start-page: 10120 year: 2006 ident: BFcr2008289_CR83 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-2399 – volume: 276 start-page: 42549 year: 2001 ident: BFcr2008289_CR32 publication-title: J Biol Chem doi: 10.1074/jbc.M107557200 – volume: 31 start-page: 572 year: 2006 ident: BFcr2008289_CR31 publication-title: Trends Biochem Sci doi: 10.1016/j.tibs.2006.08.002 – volume: 277 start-page: 2908 year: 2002 ident: BFcr2008289_CR42 publication-title: J Biol Chem doi: 10.1074/jbc.M109326200 – volume: 83 start-page: 835 year: 1995 ident: BFcr2008289_CR7 publication-title: Cell doi: 10.1016/0092-8674(95)90199-X – volume: 11 start-page: 1093 year: 2003 ident: BFcr2008289_CR26 publication-title: Mol Cell doi: 10.1016/S1097-2765(03)00112-6 – volume: 276 start-page: 28857 year: 2001 ident: BFcr2008289_CR34 publication-title: J Biol Chem doi: 10.1074/jbc.M011610200 – volume: 56 start-page: 925 year: 2002 ident: BFcr2008289_CR84 publication-title: Eur J Clin Nutr doi: 10.1038/sj.ejcn.1601396 – volume: 121 start-page: 977 year: 2005 ident: BFcr2008289_CR72 publication-title: Cell doi: 10.1016/j.cell.2005.04.014 – volume: 81 start-page: 687 year: 1995 ident: BFcr2008289_CR2 publication-title: Cell doi: 10.1016/0092-8674(95)90530-8 – volume: 45 start-page: 1538 year: 2004 ident: BFcr2008289_CR22 publication-title: J Lipid Res doi: 10.1194/jlr.M400102-JLR200 – volume: 101 start-page: 3668 year: 2004 ident: BFcr2008289_CR4 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0400046101 – volume: 281 start-page: 11039 year: 2006 ident: BFcr2008289_CR58 publication-title: J Biol Chem doi: 10.1074/jbc.M510258200 – volume: 28 start-page: 236 year: 2007 ident: BFcr2008289_CR30 publication-title: Trends Pharmacol Sci doi: 10.1016/j.tips.2007.03.002 – volume: 43 start-page: 2 year: 2002 ident: BFcr2008289_CR50 publication-title: J Lipid Res doi: 10.1016/S0022-2275(20)30180-2 – volume: 107 start-page: 49 year: 2008 ident: BFcr2008289_CR61 publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-007-9535-6 – volume: 23 start-page: 864 year: 2003 ident: BFcr2008289_CR10 publication-title: Mol Cell Biol doi: 10.1128/MCB.23.3.864-872.2003 – volume: 109 start-page: 961 year: 2002 ident: BFcr2008289_CR43 publication-title: J Clin Invest doi: 10.1172/JCI0214505 – volume: 43 start-page: S45 year: 2006 ident: BFcr2008289_CR62 publication-title: Hepatology doi: 10.1002/hep.20969 – volume: 102 start-page: 731 year: 2000 ident: BFcr2008289_CR48 publication-title: Cell doi: 10.1016/S0092-8674(00)00062-3 – volume: 441 start-page: 431 year: 2006 ident: BFcr2008289_CR70 publication-title: Nature doi: 10.1038/nature04870 – volume: 566 start-page: 173 year: 2004 ident: BFcr2008289_CR52 publication-title: FEBS Lett doi: 10.1016/j.febslet.2004.04.026 – volume: 25 start-page: 11 year: 1993 ident: BFcr2008289_CR60 publication-title: Eur Surg Res doi: 10.1159/000129252 – volume: 275 start-page: 39313 year: 2000 ident: BFcr2008289_CR39 publication-title: J Biol Chem doi: 10.1074/jbc.M007998200 – volume: 11 start-page: 119 year: 2007 ident: BFcr2008289_CR71 publication-title: Cancer Cell doi: 10.1016/j.ccr.2006.12.016 – volume: 278 start-page: 41930 year: 2003 ident: BFcr2008289_CR49 publication-title: J Biol Chem doi: 10.1074/jbc.M306309200 – volume: 103 start-page: 1006 year: 2006 ident: BFcr2008289_CR56 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0506982103 – volume: 116 start-page: 1102 year: 2006 ident: BFcr2008289_CR57 publication-title: J Clin Invest doi: 10.1172/JCI25604 – volume: 13 start-page: 1865 year: 2003 ident: BFcr2008289_CR25 publication-title: Bioorg Med Chem Lett doi: 10.1016/S0960-894X(03)00281-6 – volume: 17 start-page: 1581 year: 2003 ident: BFcr2008289_CR46 publication-title: Genes Dev doi: 10.1101/gad.1083503 – volume: 284 start-page: 1365 year: 1999 ident: BFcr2008289_CR18 publication-title: Science doi: 10.1126/science.284.5418.1365 – volume: 278 start-page: 27703 year: 2003 ident: BFcr2008289_CR38 publication-title: J Biol Chem doi: 10.1074/jbc.M302128200 – volume: 294 start-page: 1866 year: 2001 ident: BFcr2008289_CR1 publication-title: Science doi: 10.1126/science.294.5548.1866 – volume: 146 start-page: 984 year: 2005 ident: BFcr2008289_CR55 publication-title: Endocrinology doi: 10.1210/en.2004-0965 – volume: 16 start-page: 491 year: 2001 ident: BFcr2008289_CR68 publication-title: J Gastroenterol Hepatol doi: 10.1046/j.1440-1746.2001.02430.x – volume: 274 start-page: 29749 year: 1999 ident: BFcr2008289_CR36 publication-title: J Biol Chem doi: 10.1074/jbc.274.42.29749 – volume: 290 start-page: 35 year: 2002 ident: BFcr2008289_CR11 publication-title: Gene doi: 10.1016/S0378-1119(02)00557-7 – volume: 145 start-page: 1237 year: 1994 ident: BFcr2008289_CR79 publication-title: Am J Pathol – volume: 3 start-page: 543 year: 1999 ident: BFcr2008289_CR16 publication-title: Mol Cell doi: 10.1016/S1097-2765(00)80348-2 – volume: 33 start-page: 357 year: 2001 ident: BFcr2008289_CR63 publication-title: Hepatology doi: 10.1053/jhep.2001.21902 – volume: 28 start-page: 940 year: 2007 ident: BFcr2008289_CR15 publication-title: Carcinogenesis doi: 10.1093/carcin/bgl249 – volume: 315 start-page: 58 year: 2005 ident: BFcr2008289_CR81 publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.105.085597 – volume: 6 start-page: 507 year: 2000 ident: BFcr2008289_CR44 publication-title: Mol Cell doi: 10.1016/S1097-2765(00)00050-2 – volume: 15 start-page: 391 year: 1994 ident: BFcr2008289_CR8 publication-title: Endocr Rev – volume: 147 start-page: 4025 year: 2006 ident: BFcr2008289_CR20 publication-title: Endocrinology doi: 10.1210/en.2005-1485 – volume: 278 start-page: 104 year: 2003 ident: BFcr2008289_CR5 publication-title: J Biol Chem doi: 10.1074/jbc.M209505200 – volume: 43 start-page: 2971 year: 2000 ident: BFcr2008289_CR24 publication-title: J Med Chem doi: 10.1021/jm0002127 – volume: 197 start-page: 880 year: 1959 ident: BFcr2008289_CR64 publication-title: Am J Physiol doi: 10.1152/ajplegacy.1959.197.4.880 – volume: 32 start-page: 19 year: 2000 ident: BFcr2008289_CR6 publication-title: J Hepatol doi: 10.1016/S0168-8278(00)80412-2 – volume: 25 start-page: 2020 year: 2005 ident: BFcr2008289_CR29 publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/01.ATV.0000178994.21828.a7 – volume: 275 start-page: 10638 year: 2000 ident: BFcr2008289_CR40 publication-title: J Biol Chem doi: 10.1074/jbc.275.14.10638 – volume: 18 start-page: 157 year: 2004 ident: BFcr2008289_CR53 publication-title: Genes Dev doi: 10.1101/gad.1138104 – volume: 3 start-page: 149 year: 1995 ident: BFcr2008289_CR59 publication-title: Trends Microbiol doi: 10.1016/S0966-842X(00)88906-4 – volume: 78 start-page: 55 year: 1990 ident: BFcr2008289_CR65 publication-title: Clin Sci (Lond) doi: 10.1042/cs0780055 – volume: 284 start-page: 1362 year: 1999 ident: BFcr2008289_CR17 publication-title: Science doi: 10.1126/science.284.5418.1362 – ident: BFcr2008289_CR66 doi: 10.1016/S0925-4439(97)00063-X – volume: 284 start-page: G734 year: 2003 ident: BFcr2008289_CR76 publication-title: Am J Physiol Gastrointest Liver Physiol doi: 10.1152/ajpgi.00491.2002 – volume: 127 start-page: 1497 year: 2004 ident: BFcr2008289_CR80 publication-title: Gastroenterology doi: 10.1053/j.gastro.2004.08.001 – volume: 582 start-page: 10 year: 2008 ident: BFcr2008289_CR12 publication-title: FEBS Lett doi: 10.1016/j.febslet.2007.11.015 – volume: 6 start-page: 517 year: 2000 ident: BFcr2008289_CR37 publication-title: Mol Cell doi: 10.1016/S1097-2765(00)00051-4 – volume: 351 start-page: 1773 year: 1998 ident: BFcr2008289_CR35 publication-title: Lancet doi: 10.1016/S0140-6736(97)08002-1 – volume: 277 start-page: 44310 year: 2002 ident: BFcr2008289_CR67 publication-title: J Biol Chem doi: 10.1074/jbc.M207510200 – volume: 23 start-page: 621 year: 2008 ident: BFcr2008289_CR3 publication-title: Histol Histopathol – volume: 293 start-page: R1400 year: 2007 ident: BFcr2008289_CR9 publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.00781.2006 – volume: 103 start-page: 10544 year: 2006 ident: BFcr2008289_CR73 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0603499103 – volume: 66 start-page: 4001 year: 2006 ident: BFcr2008289_CR78 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-2937 – volume: 280 start-page: 7427 year: 2005 ident: BFcr2008289_CR33 publication-title: J Biol Chem doi: 10.1074/jbc.M411473200 – volume: 37 start-page: 880 year: 2003 ident: BFcr2008289_CR77 publication-title: Hepatology doi: 10.1053/jhep.2003.50175 – volume: 580 start-page: 5492 year: 2006 ident: BFcr2008289_CR28 publication-title: FEBS Lett doi: 10.1016/j.febslet.2006.07.082
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Snippet	Farnesoid X receptor （FXR） is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key... Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key...
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SubjectTerms	Bile Acids and Salts - genetics Bile Acids and Salts - metabolism Biomedical and Life Sciences Cell Biology Cholesterol Cholesterol - genetics Cholesterol - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism FXR Glucose - metabolism Life Sciences Liver - cytology Liver - physiology Liver Diseases - genetics Liver Diseases - metabolism Liver Regeneration - genetics Metabolic disorders Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism review Transcription Factors - genetics Transcription Factors - metabolism 接受器新陈代谢
Title	FXR： a metabolic regulator and cell protector
URI	http://lib.cqvip.com/qk/85240X/200811/29289270.html https://link.springer.com/article/10.1038/cr.2008.289 https://www.ncbi.nlm.nih.gov/pubmed/18825165 https://www.proquest.com/docview/1027546556 https://www.proquest.com/docview/21004432 https://www.proquest.com/docview/69737951
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