FXR： a metabolic regulator and cell protector

• Published in: Cell research Vol. 18; no. 11; pp. 1087 - 1095
• Main Authors: Wang, Yan-Dong, Chen, Wei-Dong, Moore, David D, Huang, Wendong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2008; Nature Publishing Group
• Subjects: Bile Acids and Salts - genetics; Bile Acids and Salts - metabolism; Biomedical and Life Sciences; Cell Biology; Cholesterol; Cholesterol - genetics; Cholesterol - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; FXR; Glucose - metabolism; Life Sciences; Liver - cytology; Liver - physiology; Liver Diseases - genetics; Liver Diseases - metabolism; Liver Regeneration - genetics; Metabolic disorders; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - metabolism; review; Transcription Factors - genetics; Transcription Factors - metabolism; 接受器; 新陈代谢; FXR; metabolism; hepatocarcinogenesis; bile acid; liver regeneration
• ISSN: 1001-0602; 1748-7838; 1748-7838
• DOI: 10.1038/cr.2008.289

Farnesoid X receptor （FXR） is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key roles in bile acid, cholesterol, lipid, and glucose metabolism. Therefore, FXR is a potential drug target for a number of metabolic disorders, especially those related to the metabolic syndrome. More recently, our group and others have extended the functions of FXR to more than metabolic regulation, which include anti-bacterial growth in intestine, liver regeneration, and hepatocarcinogenesis. These new findings suggest that FXR has much broader roles than previously thought, and also higi.light FXR as a drug target for multiple diseases. This review summarizes the basic information of FXR but focuses on its new functions.