Manumycin A downregulates release of proinflammatory cytokines from TNF alpha stimulated human monocytes

Highlights • We tested a potential anti-inflammatory effect of manumycin A on human macrophages. • Manumycin A downregulates proinflammatory genes in monocytic THP-1 cell line. • The release of proinflammatory cytokines by manumycin A is inhibited also in monocytes.

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Bibliographic Details
Published inImmunology letters Vol. 169; pp. 8 - 14
Main Authors Cecrdlova, Eva, Petrickova, Katerina, Kolesar, Libor, Petricek, Miroslav, Sekerkova, Alena, Svachova, Veronika, Striz, Ilja
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2016
Subjects
Allergy and Immunology
Anti-Bacterial Agents - pharmacology
Anti-Inflammatory Agents - pharmacology
Cell Line
Cytokines
Cytokines - genetics
Cytokines - metabolism
Early Growth Response Protein 1 - genetics
Early Growth Response Protein 1 - metabolism
Gene Expression Regulation - drug effects
Humans
Immunomodulation
Inflammation - drug therapy
Inflammation - immunology
Manumycin A
Monocytes
Monocytes - drug effects
Monocytes - immunology
Polyenes - pharmacology
Polyunsaturated Alkamides - pharmacology
Receptors, Interleukin-1 - genetics
Receptors, Interleukin-1 - metabolism
RNA, Messenger - genetics
Streptomycetes
THP-1 cells
Toll-Like Receptor 8 - genetics
Toll-Like Receptor 8 - metabolism
Tumor Necrosis Factor-alpha - metabolism
THP-1 cells
Monocytes
Cytokines
Immunomodulation
Manumycin A
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Summary:Highlights • We tested a potential anti-inflammatory effect of manumycin A on human macrophages. • Manumycin A downregulates proinflammatory genes in monocytic THP-1 cell line. • The release of proinflammatory cytokines by manumycin A is inhibited also in monocytes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2015.11.010