The biology and chemistry of hyperlipidemia

• Published in: Bioorganic & medicinal chemistry Vol. 15; no. 14; pp. 4674 - 4699
• Main Authors: Jain, Kishor S., Kathiravan, M.K., Somani, Rahul S., Shishoo, Chamanlal J.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 15.07.2007; Elsevier Science
• Subjects: Animals; Antiatherogenic; Atherosclerosis; Atherosclerosis - metabolism; Biochemical Phenomena; Biochemistry; Biological and medical sciences; Cholesterol; Co-enzyme Q10; Disease Progression; Drug Design; General and cellular metabolism. Vitamins; Humans; Hyperlipidemias - drug therapy; Hyperlipidemias - metabolism; Hyperlipidemias - pathology; Lipoproteins; Lipoproteins - metabolism; Medical sciences; Oxidation; Pharmacology. Drug treatments; Squalene epoxidase; Squalene synthase; Statins; Lipoproteins; Squalene epoxidase; Atherosclerosis; Antiatherogenic; Co-enzyme Q10; Oxidation; Squalene synthase; Cholesterol; Statins; Pathogenesis; Cardiovascular disease; Lipids; Review; Lipoprotein; Vascular disease; Prevention; Ubiquinone; Hyperlipemia; Dyslipemia; Atheroma; Enzyme inhibitor; Metabolic diseases; Statin derivative; Antioxidant; Coronary heart disease; Protein; Coenzyme; Chemotherapy; Treatment; Antilipemic agent
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/j.bmc.2007.04.031

Coronary arterial diseases are responsible for more deaths than all other associated causes combined. Elevated serum cholesterol levels leading to atherosclerosis can cause coronary heart disease (CHD). Reduction in serum cholesterol levels reduces the risk for CHD, substantially. Medicinal chemists all around the world have been designing, synthesizing, and evaluating a variety of new bioactive molecules for lowering lipid levels. This review summarizes the disorders associated with elevation of lipids in blood and the current strategies to control them. The emphasis has been laid in particular on the new potential biological targets and the possible treatments as well as the current ongoing research status in the field of lipid lowering agents.