A therapeutic approach to early vocal cord carcinoma

One hundred and twenty patients with early glottic carcinoma received radiation therapy at the University of Maryland Hospital from 1959 to 1977. The radiation dose ranged from 55 Gy in 4 weeks for small T1a lesions to 65 Gy in 61/2 weeks for T2 lesions. The local control rates by irradiation alone...

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Bibliographic Details
Published inActa radiologica. Oncology Vol. 24; no. 4; p. 321
Main Authors Amornmarn, R, Prempree, T, Viravathana, T, Donavanik, V, Wizenberg, M J
Format Journal Article
LanguageEnglish
Published Sweden 01.01.1985
Subjects
Adult
Aged
Cobalt Radioisotopes - therapeutic use
Female
Humans
Laryngeal Neoplasms - mortality
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - radiotherapy
Male
Middle Aged
Neoplasm Staging
Prognosis
Radioisotope Teletherapy
Vocal Cords
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Summary:One hundred and twenty patients with early glottic carcinoma received radiation therapy at the University of Maryland Hospital from 1959 to 1977. The radiation dose ranged from 55 Gy in 4 weeks for small T1a lesions to 65 Gy in 61/2 weeks for T2 lesions. The local control rates by irradiation alone for stages T1a, T1b, and T2 were 92, 91 and 88 per cent, respectively, while 5-year determinate disease-free survival rates were 96 per cent for stage I disease and 88 per cent for stage II disease. Most of the local failures were salvaged by surgery, with a low complication rate. Regional metastases were uncommon, and occurred in 7 per cent in stage I and in 6 per cent in stage II disease. Factors increasing the risk of failures appeared to be bulky tumor, anterior commissure involvement and subglottic extension.
ISSN:0349-652X
DOI:10.3109/02841868509136059