Effect of 5-HT2A receptor polymorphisms and occupational stress on self-reported sleep quality: a cross-sectional study in Xinjiang, China

Highlights • 5-HTR2A genes were related to sleep latency, sleep duration, sleep efficiency and daytime dysfunction. • Occupational stress played a predominant role in the risk of poor sleep quality. • The effect of 5-HTR2A for sleep quality was relatively weaker than high occupational stress. • Ther...

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Bibliographic Details
Published inSleep medicine Vol. 20; pp. 30 - 36
Main Authors Jiang, Yu, Cui, Changyong, Ge, Hua, Guan, Suzhen, Lian, Yulong, Liu, Jiwen
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.04.2016
Subjects
5-HTR2A
Adult
Alleles
China
Cross-Sectional Studies
Environment–gene interaction
Female
Gene-Environment Interaction
Genotype
Humans
Male
Middle Aged
Neurology
Occupational Health
Occupational stress
Polymorphism, Single Nucleotide
Receptor, Serotonin, 5-HT2A - genetics
Self Report
Sleep Initiation and Maintenance Disorders - genetics
Sleep Medicine
Sleep quality
Surveys and Questionnaires
Occupational stress
Sleep quality
Environment–gene interaction
5-HTR2A
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Summary:Highlights • 5-HTR2A genes were related to sleep latency, sleep duration, sleep efficiency and daytime dysfunction. • Occupational stress played a predominant role in the risk of poor sleep quality. • The effect of 5-HTR2A for sleep quality was relatively weaker than high occupational stress. • There was a significant interaction between 5-HTR2A genotype and occupational stress in the risk of poor sleep quality.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2015.12.007