Layer-by-layer assembled nanorough iridium-oxide/platinum-black for low-voltage microscale electrode neurostimulation

• Published in: Sensors and actuators. B, Chemical Vol. 206; pp. 205 - 211
• Main Authors: Yamagiwa, Shota, Fujishiro, Akifumi, Sawahata, Hirohito, Numano, Rika, Ishida, Makoto, Kawano, Takeshi
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2015
• Subjects: AIROF; Microelectrode; Nano-porous; Neural stimulation; Microelectrode; Neural stimulation; Nano-porous; AIROF
• ISSN: 0925-4005; 1873-3077
• DOI: 10.1016/j.snb.2014.09.048

•A low impedance and high charge-injection material with an enhanced surface area is proposed.•A layer-by-layer assembly of IrOx/Pt-black with nanoroughness is fabricated.•IrOx/Pt-black has half the impedance and 2.4 times QCDC of a same-sized flat-IrOx.•In vivo electrical stimulation of the sciatic nerve of a mouse is demonstrated using a low voltage IrOx/Pt-black plated microelectrode. Electrical neural stimulating electrodes play an important role in medical applications and improving health/medical conditions. However, size reduction for low-invasive electrodes creates issues with high electrolyte/electrode interfacial impedance and low charge-injection characteristics, which makes it impossible to stimulate neurons/cells. To overcome these limitations, we propose an electrode material for low-voltage microscale electrode neurostimulation that combines the advantages of low impedance of iridium oxide (IrOx) with the enhanced surface area of platinum black (Pt-black). Based on a simple, rapid, low-temperature electroplating process, herein a low impedance and high charge-injection electrode is fabricated by a layer-by-layer assembly of IrOx/Pt-black with nanoscale roughness. The assembled nanorough-IrOx/Pt-black electrode has an impedance of 32 Ωcm2 at 1kHz and a charge-injection delivery capacity (QCDC) of 46.7mCcm−2, which are 0.5 and 2.4 times the values for the same-sized IrOx/flat-Pt electrode, respectively. The stimulation capability of the nanorough-IrOx/Pt-black plated microelectrode is confirmed by in vivo stimulations of the sciatic nerve of a mouse. The threshold voltages of 8-μm-diameter and 11-μm-diameter electrodes are 700mV and 300mV, respectively. However, increasing the diameter of high QCDC nanorough-IrOx/Pt-black can further reduce the stimulation voltage. Consequently, nanorough-IrOx/Pt-black is applicable to low-voltage microscale electrode neurostimulations for powerful in vivo/in vitro electrophysiological measurements.