Kinetics, Thermodynamics, and the Problem of Selectivity: The Maturation of an Idea

Why so slow? Why did it take several decades for the concept of selectivity to develop into a fundamental consideration in organic chemistry? The Essay describes the reception by the scientific community in the first half of the 20th century of the principles of kinetic versus thermodynamic control...

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Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 45; no. 29; pp. 4724 - 4729
Main Author Berson, Jerome A.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 17.07.2006
WILEY‐VCH Verlag
Subjects
history of science
kinetics
reaction mechanisms
selectivity
thermodynamics
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Summary:Why so slow? Why did it take several decades for the concept of selectivity to develop into a fundamental consideration in organic chemistry? The Essay describes the reception by the scientific community in the first half of the 20th century of the principles of kinetic versus thermodynamic control and explains the physical basis of selectivity (see picture: energy diagram for the reaction of pentamethylenefulvene (A) and maleic anhydride (B)).
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content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200600229