Clinical trial: the effect of somatostatin vs. octreotide in preventing post‐endoscopic increase in hepatic venous pressure gradient in cirrhotics with bleeding varices

• Published in: Alimentary pharmacology & therapeutics Vol. 26; no. 11‐12; pp. 1479 - 1487
• Main Authors: VLACHOGIANNAKOS, J., KOUGIOUMTZIAN, A., TRIANTOS, C., VIAZIS, N., SGOUROS, S., MANOLAKOPOULOS, S., SAVERIADIS, A., MARKOGLOU, C., ECONOMOPOULOS, T., KARAMANOLIS, D. G.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2007; Blackwell
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Digestive system; Double-Blind Method; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices - mortality; Esophageal and Gastric Varices - therapy; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal Hemorrhage - mortality; Gastrointestinal Hemorrhage - therapy; Hepatic Veins - physiopathology; Humans; Liver Cirrhosis - complications; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Octreotide - adverse effects; Octreotide - therapeutic use; Other diseases. Semiology; Pharmacology. Drug treatments; Prospective Studies; Recurrence; Sclerotherapy - adverse effects; Somatostatin - adverse effects; Somatostatin - therapeutic use; Treatment Failure; Venous Pressure - drug effects; Human; Gradient; Digestive system; Liver; Peptide hormone; Hepatic disease; Octreotide; Neuropeptide; Hemorrhage; Prevention; Cirrhosis; Analog; Digestive diseases; Clinical trial; Hemodynamics; Endoscopy; Somatostatin; Comparative study; Venous pressure
• ISSN: 0269-2813; 1365-2036
• DOI: 10.1111/j.1365-2036.2007.03539.x

Summary Background Hepatic venous pressure gradient (HVPG) increases significantly after endoscopic therapy in patients with bleeding oesophageal varices, which may precipitate further haemorrhage. Whether vasoactive drugs can suppress these changes remains unknown. Aim To investigate the efficacy of somatostatin when compared with octreotide in preventing the post‐endoscopic increase in HVPG during acute bleeding and whether the changes affect outcome. Methods Thirty‐three cirrhotics with bleeding varices were randomized to receive somatostatin (n = 17) or octreotide (n = 16) under double‐blind conditions, soon after their admission. HVPG measurements were performed before and immediately after endoscopic treatment. Results In the somatostatin group, postendotherapy HVPG values did not change significantly when compared with pre‐treatment values (18.9 vs. 17.2, P = 0.092). Conversely, in the octreotide group, HVPG increased significantly after endoscopy (18.2 vs. 20.8, P = 0.003). The probability of 6‐week survival without treatment failure was significantly higher in the somatostatin group (P = 0.024). Post‐endoscopic HVPG value was independently associated with 6‐week failure. Conclusions Somatostatin, but not octreotide, effectively prevents the post‐endoscopic increase in HVPG, which may be associated with low probability of treatment failure.