Folate antagonism following teratogenic exposure to diphenylhydantoin

Previous studies have reported indirect evidence for the mediation of folate antagonism in the induction of malformations by diphenylhydantion. We have demonstrated that a teratogenic regimen of folate-deficiency and antagonism using 9-methyl PGA in the rat produces significantly decreased rates of...

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Bibliographic Details
Published inTeratology (Philadelphia) Vol. 19; no. 1; p. 45
Main Authors Netzloff, M L, Streiff, R R, Frias, J L, Rennert, O M
Format Journal Article
LanguageEnglish
Published United States 01.02.1979
Subjects
Abnormalities, Drug-Induced - etiology
Animals
Female
Fetal Resorption - chemically induced
Fetus - metabolism
Folic Acid Antagonists - toxicity
Folic Acid Deficiency - chemically induced
Male
Mice
Oxygen Consumption - drug effects
Phenytoin - toxicity
Pregnancy
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Summary:Previous studies have reported indirect evidence for the mediation of folate antagonism in the induction of malformations by diphenylhydantion. We have demonstrated that a teratogenic regimen of folate-deficiency and antagonism using 9-methyl PGA in the rat produces significantly decreased rates of oxygen consumption in the maldeveloping embryos. The present study reports similar reductions in oxygen uptake by mouse embryos from mothers treated with teratogenic doses of diphenylhydantoin, and documents a significant depression of the actual folate levels in such embryos. The differences are less significant with lower doses of diphenylhydantoin, and do not occur with a nonteratogenic dose.
ISSN:0040-3709
DOI:10.1002/tera.1420190108